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Risk factors for autism: perinatal factors, parental psychiatric history, and socioeconomic status.
Am J Epidemiol. 2005 May 15; 161(10):916-25; discussion 926-8.AJ

Abstract

Research suggests that heredity and early fetal development play a causal role in autism. This case-control study explored the association between perinatal factors, parental psychiatric history, socioeconomic status, and risk of autism. The study was nested within a cohort of all children born in Denmark after 1972 and at risk of being diagnosed with autism until December 1999. Prospectively recorded data were obtained from nationwide registries in Denmark. Cases totaled 698 children with a diagnosis of autism; each case was individually matched by gender, birth year, and age to 25 controls. Analyses by conditional logistic regression produced risk ratios and 95% confidence intervals. Adjusted analyses showed that the risk of autism was associated with breech presentation (risk ratio (RR) = 1.63, 95% confidence interval (CI): 1.18, 2.26), low Apgar score at 5 minutes (RR = 1.89, 95% CI: 1.10, 3.27), gestational age at birth <35 weeks (RR = 2.45, 95% CI: 1.55, 3.86), and parental psychiatric history (schizophrenia-like psychosis: RR = 3.44, 95% CI: 1.48, 7.95; affective disorder: RR = 2.91, 95% CI: 1.65, 5.14). Analyses showed no statistically significant association between risk of autism and weight for gestational age, parity, number of antenatal visits, parental age, or socioeconomic status. Results suggest that prenatal environmental factors and parental psychopathology are associated with the risk of autism. These factors seem to act independently.

Authors+Show Affiliations

North Atlantic Neuro-Epidemiology Alliances, Department of Epidemiology and Social Medicine, University of Aarhus, Aarhus, Denmark.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

15870155

Citation

Larsson, Heidi Jeanet, et al. "Risk Factors for Autism: Perinatal Factors, Parental Psychiatric History, and Socioeconomic Status." American Journal of Epidemiology, vol. 161, no. 10, 2005, pp. 916-25; discussion 926-8.
Larsson HJ, Eaton WW, Madsen KM, et al. Risk factors for autism: perinatal factors, parental psychiatric history, and socioeconomic status. Am J Epidemiol. 2005;161(10):916-25; discussion 926-8.
Larsson, H. J., Eaton, W. W., Madsen, K. M., Vestergaard, M., Olesen, A. V., Agerbo, E., Schendel, D., Thorsen, P., & Mortensen, P. B. (2005). Risk factors for autism: perinatal factors, parental psychiatric history, and socioeconomic status. American Journal of Epidemiology, 161(10), 916-25; discussion 926-8.
Larsson HJ, et al. Risk Factors for Autism: Perinatal Factors, Parental Psychiatric History, and Socioeconomic Status. Am J Epidemiol. 2005 May 15;161(10):916-25; discussion 926-8. PubMed PMID: 15870155.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Risk factors for autism: perinatal factors, parental psychiatric history, and socioeconomic status. AU - Larsson,Heidi Jeanet, AU - Eaton,William W, AU - Madsen,Kreesten Meldgaard, AU - Vestergaard,Mogens, AU - Olesen,Anne Vingaard, AU - Agerbo,Esben, AU - Schendel,Diana, AU - Thorsen,Poul, AU - Mortensen,Preben Bo, PY - 2005/5/5/pubmed PY - 2005/6/29/medline PY - 2005/5/5/entrez SP - 916-25; discussion 926-8 JF - American journal of epidemiology JO - Am. J. Epidemiol. VL - 161 IS - 10 N2 - Research suggests that heredity and early fetal development play a causal role in autism. This case-control study explored the association between perinatal factors, parental psychiatric history, socioeconomic status, and risk of autism. The study was nested within a cohort of all children born in Denmark after 1972 and at risk of being diagnosed with autism until December 1999. Prospectively recorded data were obtained from nationwide registries in Denmark. Cases totaled 698 children with a diagnosis of autism; each case was individually matched by gender, birth year, and age to 25 controls. Analyses by conditional logistic regression produced risk ratios and 95% confidence intervals. Adjusted analyses showed that the risk of autism was associated with breech presentation (risk ratio (RR) = 1.63, 95% confidence interval (CI): 1.18, 2.26), low Apgar score at 5 minutes (RR = 1.89, 95% CI: 1.10, 3.27), gestational age at birth <35 weeks (RR = 2.45, 95% CI: 1.55, 3.86), and parental psychiatric history (schizophrenia-like psychosis: RR = 3.44, 95% CI: 1.48, 7.95; affective disorder: RR = 2.91, 95% CI: 1.65, 5.14). Analyses showed no statistically significant association between risk of autism and weight for gestational age, parity, number of antenatal visits, parental age, or socioeconomic status. Results suggest that prenatal environmental factors and parental psychopathology are associated with the risk of autism. These factors seem to act independently. SN - 0002-9262 UR - https://www.unboundmedicine.com/medline/citation/15870155/Risk_factors_for_autism:_perinatal_factors_parental_psychiatric_history_and_socioeconomic_status_ L2 - https://academic.oup.com/aje/article-lookup/doi/10.1093/aje/kwi123 DB - PRIME DP - Unbound Medicine ER -