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Effect of adiposity and fat distribution on endometrial cancer risk in Shanghai women.
Am J Epidemiol. 2005 May 15; 161(10):939-47.AJ

Abstract

The authors conducted a population-based case-control study of 832 endometrial cancer cases and 846 frequency-matched controls in Shanghai, China (1997-2001), to examine the association of overall adiposity and body fat distribution with disease risk. Overall adiposity was estimated using weight and body mass index (BMI); upper body fat distribution was evaluated using waist circumference and waist:hip ratio. Overall and upper-body obesity were both associated with an elevated risk of endometrial cancer. Adjusted odds ratios and 95% confidence intervals for highest-versus-lowest quartile comparisons were 2.6 (95% confidence interval (CI): 2.0, 3.5) for weight, 2.9 (95% CI: 2.2, 3.9) for BMI, 4.7 (95% CI: 3.4, 6.4) for waist circumference, and 3.5 (95% CI: 2.6, 4.8) for waist:hip ratio. The positive associations with weight and BMI vanished after results were controlled for waist circumference, while associations with waist circumference and waist:hip ratio persisted after adjustment for BMI. The positive association with upper-body obesity was more pronounced among younger women, women who had never used oral contraceptives, and women with a history of diabetes mellitus (p for multiplicative interaction < 0.05). Upper-body obesity was related to increased risk among women with low BMI. These results suggest that obesity, particularly upper-body fat deposition, is associated with an increased risk of endometrial cancer.

Authors+Show Affiliations

Department of Epidemiology, Shanghai Cancer Institute, Shanghai, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

15870158

Citation

Xu, Wang Hong, et al. "Effect of Adiposity and Fat Distribution On Endometrial Cancer Risk in Shanghai Women." American Journal of Epidemiology, vol. 161, no. 10, 2005, pp. 939-47.
Xu WH, Matthews CE, Xiang YB, et al. Effect of adiposity and fat distribution on endometrial cancer risk in Shanghai women. Am J Epidemiol. 2005;161(10):939-47.
Xu, W. H., Matthews, C. E., Xiang, Y. B., Zheng, W., Ruan, Z. X., Cheng, J. R., Gao, Y. T., & Shu, X. O. (2005). Effect of adiposity and fat distribution on endometrial cancer risk in Shanghai women. American Journal of Epidemiology, 161(10), 939-47.
Xu WH, et al. Effect of Adiposity and Fat Distribution On Endometrial Cancer Risk in Shanghai Women. Am J Epidemiol. 2005 May 15;161(10):939-47. PubMed PMID: 15870158.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of adiposity and fat distribution on endometrial cancer risk in Shanghai women. AU - Xu,Wang Hong, AU - Matthews,Charles E, AU - Xiang,Yong Bing, AU - Zheng,Wei, AU - Ruan,Zhi Xian, AU - Cheng,Jia Rong, AU - Gao,Yu Tang, AU - Shu,Xiao Ou, PY - 2005/5/5/pubmed PY - 2005/6/29/medline PY - 2005/5/5/entrez SP - 939 EP - 47 JF - American journal of epidemiology JO - Am. J. Epidemiol. VL - 161 IS - 10 N2 - The authors conducted a population-based case-control study of 832 endometrial cancer cases and 846 frequency-matched controls in Shanghai, China (1997-2001), to examine the association of overall adiposity and body fat distribution with disease risk. Overall adiposity was estimated using weight and body mass index (BMI); upper body fat distribution was evaluated using waist circumference and waist:hip ratio. Overall and upper-body obesity were both associated with an elevated risk of endometrial cancer. Adjusted odds ratios and 95% confidence intervals for highest-versus-lowest quartile comparisons were 2.6 (95% confidence interval (CI): 2.0, 3.5) for weight, 2.9 (95% CI: 2.2, 3.9) for BMI, 4.7 (95% CI: 3.4, 6.4) for waist circumference, and 3.5 (95% CI: 2.6, 4.8) for waist:hip ratio. The positive associations with weight and BMI vanished after results were controlled for waist circumference, while associations with waist circumference and waist:hip ratio persisted after adjustment for BMI. The positive association with upper-body obesity was more pronounced among younger women, women who had never used oral contraceptives, and women with a history of diabetes mellitus (p for multiplicative interaction < 0.05). Upper-body obesity was related to increased risk among women with low BMI. These results suggest that obesity, particularly upper-body fat deposition, is associated with an increased risk of endometrial cancer. SN - 0002-9262 UR - https://www.unboundmedicine.com/medline/citation/15870158/Effect_of_adiposity_and_fat_distribution_on_endometrial_cancer_risk_in_Shanghai_women_ L2 - https://academic.oup.com/aje/article-lookup/doi/10.1093/aje/kwi127 DB - PRIME DP - Unbound Medicine ER -