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Neonatal measles immunity in rural Kenya: the influence of HIV and placental malaria infections on placental transfer of antibodies and levels of antibody in maternal and cord serum samples.
J Infect Dis. 2005 Jun 01; 191(11):1854-60.JI

Abstract

INTRODUCTION

Young infants are protected from measles infection by maternal measles antibodies. The level of these antibodies at birth depends on the level of antibodies in the mother and the extent of placental transfer. We investigated predictors of levels of measles antibodies in newborns in rural Kenya.

METHODS

A total of 747 paired maternal-cord serum samples (91 from human immunodeficiency virus [HIV]-infected and 656 from HIV-uninfected mothers) were tested for measles immunoglobulin G antibodies. Placental malaria infection was determined by biopsy. Data on pregnancy history, gestational age, and anthropometric and socioeconomic status were collected.

RESULTS

Infants born to HIV-infected mothers were more likely (odds ratio, 4.6 [95% confidence interval {CI}, 2.2-9.7]) to be seronegative and had 35.1% (95% CI, 9.8%-53.2%) lower levels of measles antibodies than did those born to HIV-uninfected mothers. Preterm delivery, early maternal age, and ethnic group were also associated with reduced levels of measles antibodies. There was little evidence that placental malaria infection was associated with levels of measles antibodies in newborns.

CONCLUSION

Our results suggest that maternal HIV infection may reduce levels of measles antibodies in newborns. Low levels of measles antibodies at birth render children susceptible to measles infection at an early age. This is of concern in sub-Saharan African countries, where not only is the prevalence of HIV high, but measles is the cause of much morbidity and mortality.

Authors+Show Affiliations

Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom. Susana.Scott@lshtm.ac.ukNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15871118

Citation

Scott, Susana, et al. "Neonatal Measles Immunity in Rural Kenya: the Influence of HIV and Placental Malaria Infections On Placental Transfer of Antibodies and Levels of Antibody in Maternal and Cord Serum Samples." The Journal of Infectious Diseases, vol. 191, no. 11, 2005, pp. 1854-60.
Scott S, Cumberland P, Shulman CE, et al. Neonatal measles immunity in rural Kenya: the influence of HIV and placental malaria infections on placental transfer of antibodies and levels of antibody in maternal and cord serum samples. J Infect Dis. 2005;191(11):1854-60.
Scott, S., Cumberland, P., Shulman, C. E., Cousens, S., Cohen, B. J., Brown, D. W., Bulmer, J. N., Dorman, E. K., Kawuondo, K., Marsh, K., & Cutts, F. (2005). Neonatal measles immunity in rural Kenya: the influence of HIV and placental malaria infections on placental transfer of antibodies and levels of antibody in maternal and cord serum samples. The Journal of Infectious Diseases, 191(11), 1854-60.
Scott S, et al. Neonatal Measles Immunity in Rural Kenya: the Influence of HIV and Placental Malaria Infections On Placental Transfer of Antibodies and Levels of Antibody in Maternal and Cord Serum Samples. J Infect Dis. 2005 Jun 1;191(11):1854-60. PubMed PMID: 15871118.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Neonatal measles immunity in rural Kenya: the influence of HIV and placental malaria infections on placental transfer of antibodies and levels of antibody in maternal and cord serum samples. AU - Scott,Susana, AU - Cumberland,Phillippa, AU - Shulman,Caroline E, AU - Cousens,Simon, AU - Cohen,Bernard J, AU - Brown,David W G, AU - Bulmer,Judith N, AU - Dorman,Edgar K, AU - Kawuondo,Ken, AU - Marsh,Kevin, AU - Cutts,Felicity, Y1 - 2005/04/20/ PY - 2004/10/25/received PY - 2004/12/28/accepted PY - 2005/5/5/pubmed PY - 2005/7/12/medline PY - 2005/5/5/entrez SP - 1854 EP - 60 JF - The Journal of infectious diseases JO - J Infect Dis VL - 191 IS - 11 N2 - INTRODUCTION: Young infants are protected from measles infection by maternal measles antibodies. The level of these antibodies at birth depends on the level of antibodies in the mother and the extent of placental transfer. We investigated predictors of levels of measles antibodies in newborns in rural Kenya. METHODS: A total of 747 paired maternal-cord serum samples (91 from human immunodeficiency virus [HIV]-infected and 656 from HIV-uninfected mothers) were tested for measles immunoglobulin G antibodies. Placental malaria infection was determined by biopsy. Data on pregnancy history, gestational age, and anthropometric and socioeconomic status were collected. RESULTS: Infants born to HIV-infected mothers were more likely (odds ratio, 4.6 [95% confidence interval {CI}, 2.2-9.7]) to be seronegative and had 35.1% (95% CI, 9.8%-53.2%) lower levels of measles antibodies than did those born to HIV-uninfected mothers. Preterm delivery, early maternal age, and ethnic group were also associated with reduced levels of measles antibodies. There was little evidence that placental malaria infection was associated with levels of measles antibodies in newborns. CONCLUSION: Our results suggest that maternal HIV infection may reduce levels of measles antibodies in newborns. Low levels of measles antibodies at birth render children susceptible to measles infection at an early age. This is of concern in sub-Saharan African countries, where not only is the prevalence of HIV high, but measles is the cause of much morbidity and mortality. SN - 0022-1899 UR - https://www.unboundmedicine.com/medline/citation/15871118/Neonatal_measles_immunity_in_rural_Kenya:_the_influence_of_HIV_and_placental_malaria_infections_on_placental_transfer_of_antibodies_and_levels_of_antibody_in_maternal_and_cord_serum_samples_ L2 - https://academic.oup.com/jid/article-lookup/doi/10.1086/429963 DB - PRIME DP - Unbound Medicine ER -