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Significant differential effects of lower doses of hormone therapy or tibolone on markers of cardiovascular disease in post-menopausal women: a randomized, double-blind, crossover study.
Eur Heart J 2005; 26(14):1362-8EH

Abstract

AIMS

We have previously reported that lower doses of hormone therapy (L-HT) and tibolone have different effects on markers of cardiovascular disease when compared with conventional doses of HT. The objective was to compare the effects of L-HT and tibolone on lipid profile, vasodilation, and factors associated with inflammation and haemostasis.

METHODS AND RESULTS

Forty-one women received a combination of micronized progesterone 100 mg with conjugated equine estrogen 0.3 mg vs. tibolone 2.5 mg alone daily in random order during 2 months with 2 months washout period. When compared with L-HT, tibolone significantly reduced total cholesterol (P<0.001), triglyceride (P<0.001), HDL cholesterol (P<0.001) levels, and triglyceride/HDL cholesterol ratios (P=0.004) except total cholesterol/HDL cholesterol ratios. Tibolone improved flow-mediated response to hyperaemia from baseline values (P<0.001) by a similar magnitude to L-HT. L-HT and tibolone did not increase high-sensitivity C-reactive protein relative to baseline values. L-HT reduced antithrombin III from baseline values (P=0.037), compared with tibolone showing no changes. However, there was no difference between either. In contrast, tibolone increased pro-thrombin fragment 1+2 (F1+2) from baseline values (P=0.002), compared with L-HT showing no changes. Tibolone significantly reduced plasma plasminogen activator inhibitor type 1 (PAI-1) antigen levels from baseline values (P=0.004), compared with L-HT showing no changes. The effects of L-HT and tibolone on F1+2 and PAI-1 were significantly different (P=0.045 and P=0.008, respectively).

CONCLUSION

Both tibolone and L-HT improved flow-mediated response by a similar magnitude and did not significantly increase high-sensitivity C-reactive protein. However, tibolone significantly reduced PAI-1, but increased F1+2 more than L-HT.

Authors+Show Affiliations

Division of Cardiology, Gil Heart Center, Gachon Medical School, 1198 Kuwol-dong, Namdong-gu, Incheon 405-760, Korea. kwangk@ghil.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

15872028

Citation

Koh, Kwang Kon, et al. "Significant Differential Effects of Lower Doses of Hormone Therapy or Tibolone On Markers of Cardiovascular Disease in Post-menopausal Women: a Randomized, Double-blind, Crossover Study." European Heart Journal, vol. 26, no. 14, 2005, pp. 1362-8.
Koh KK, Han SH, Shin MS, et al. Significant differential effects of lower doses of hormone therapy or tibolone on markers of cardiovascular disease in post-menopausal women: a randomized, double-blind, crossover study. Eur Heart J. 2005;26(14):1362-8.
Koh, K. K., Han, S. H., Shin, M. S., Ahn, J. Y., Lee, Y., & Shin, E. K. (2005). Significant differential effects of lower doses of hormone therapy or tibolone on markers of cardiovascular disease in post-menopausal women: a randomized, double-blind, crossover study. European Heart Journal, 26(14), pp. 1362-8.
Koh KK, et al. Significant Differential Effects of Lower Doses of Hormone Therapy or Tibolone On Markers of Cardiovascular Disease in Post-menopausal Women: a Randomized, Double-blind, Crossover Study. Eur Heart J. 2005;26(14):1362-8. PubMed PMID: 15872028.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Significant differential effects of lower doses of hormone therapy or tibolone on markers of cardiovascular disease in post-menopausal women: a randomized, double-blind, crossover study. AU - Koh,Kwang Kon, AU - Han,Seung Hwan, AU - Shin,Mi-Seung, AU - Ahn,Jeong Yeal, AU - Lee,Yonghee, AU - Shin,Eak Kyun, Y1 - 2005/05/04/ PY - 2005/5/6/pubmed PY - 2005/10/21/medline PY - 2005/5/6/entrez SP - 1362 EP - 8 JF - European heart journal JO - Eur. Heart J. VL - 26 IS - 14 N2 - AIMS: We have previously reported that lower doses of hormone therapy (L-HT) and tibolone have different effects on markers of cardiovascular disease when compared with conventional doses of HT. The objective was to compare the effects of L-HT and tibolone on lipid profile, vasodilation, and factors associated with inflammation and haemostasis. METHODS AND RESULTS: Forty-one women received a combination of micronized progesterone 100 mg with conjugated equine estrogen 0.3 mg vs. tibolone 2.5 mg alone daily in random order during 2 months with 2 months washout period. When compared with L-HT, tibolone significantly reduced total cholesterol (P<0.001), triglyceride (P<0.001), HDL cholesterol (P<0.001) levels, and triglyceride/HDL cholesterol ratios (P=0.004) except total cholesterol/HDL cholesterol ratios. Tibolone improved flow-mediated response to hyperaemia from baseline values (P<0.001) by a similar magnitude to L-HT. L-HT and tibolone did not increase high-sensitivity C-reactive protein relative to baseline values. L-HT reduced antithrombin III from baseline values (P=0.037), compared with tibolone showing no changes. However, there was no difference between either. In contrast, tibolone increased pro-thrombin fragment 1+2 (F1+2) from baseline values (P=0.002), compared with L-HT showing no changes. Tibolone significantly reduced plasma plasminogen activator inhibitor type 1 (PAI-1) antigen levels from baseline values (P=0.004), compared with L-HT showing no changes. The effects of L-HT and tibolone on F1+2 and PAI-1 were significantly different (P=0.045 and P=0.008, respectively). CONCLUSION: Both tibolone and L-HT improved flow-mediated response by a similar magnitude and did not significantly increase high-sensitivity C-reactive protein. However, tibolone significantly reduced PAI-1, but increased F1+2 more than L-HT. SN - 0195-668X UR - https://www.unboundmedicine.com/medline/citation/15872028/Significant_differential_effects_of_lower_doses_of_hormone_therapy_or_tibolone_on_markers_of_cardiovascular_disease_in_post_menopausal_women:_a_randomized_double_blind_crossover_study_ L2 - https://academic.oup.com/eurheartj/article-lookup/doi/10.1093/eurheartj/ehi311 DB - PRIME DP - Unbound Medicine ER -