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Anxiety disorders among patients with co-occurring bipolar and substance use disorders.
Drug Alcohol Depend. 2005 Nov 01; 80(2):251-7.DA

Abstract

Bipolar and substance use disorders are known to co-occur frequently, but limited attention has been paid to anxiety disorders that may accompany this dual diagnosis. Therefore, we examined the prevalence and nature of anxiety disorders among treatment-seeking patients diagnosed with current bipolar and substance use disorders, and investigated the association between anxiety disorders and substance use. Among 90 participants diagnosed with bipolar disorder I (n = 75, 78%) or II (n = 15, 22%), 43 (48%) had a lifetime anxiety disorder, with post-traumatic stress disorder (PTSD) occurring most frequently (n = 21, 23%). We found that those with PTSD, but not with the other anxiety disorders assessed, began using drugs at an earlier age and had more lifetime substance use disorders, particularly cocaine and amphetamine use disorders, than those without PTSD. Further examination revealed that (1) most participants with PTSD were women, (2) sexual abuse was the most frequently reported index trauma, and (3) the mean age of the earliest index trauma occurred before the mean age of initiation of drug use. Our findings point to the importance of further investigating the ramifications of a trauma history among those who are dually diagnosed with bipolar and substance use disorders.

Authors+Show Affiliations

Kolodziej ME
The Alcohol and Drug Abuse Treatment Program, McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA. mkolodziej@mclean.harvard.edu
Griffin ML
No affiliation info available
Najavits LM
No affiliation info available
Otto MW
No affiliation info available
Greenfield SF
No affiliation info available
Weiss RD
No affiliation info available

MeSH

AdultAnxiety DisordersBipolar DisorderComorbidityDemographyDiagnosis, Dual (Psychiatry)Diagnostic and Statistical Manual of Mental DisordersFemaleHumansMaleSeverity of Illness IndexStress Disorders, Post-TraumaticSubstance-Related Disorders

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

15876498

Citation

Kolodziej, Monika E., et al. "Anxiety Disorders Among Patients With Co-occurring Bipolar and Substance Use Disorders." Drug and Alcohol Dependence, vol. 80, no. 2, 2005, pp. 251-7.
Kolodziej ME, Griffin ML, Najavits LM, et al. Anxiety disorders among patients with co-occurring bipolar and substance use disorders. Drug Alcohol Depend. 2005;80(2):251-7.
Kolodziej, M. E., Griffin, M. L., Najavits, L. M., Otto, M. W., Greenfield, S. F., & Weiss, R. D. (2005). Anxiety disorders among patients with co-occurring bipolar and substance use disorders. Drug and Alcohol Dependence, 80(2), 251-7.
Kolodziej ME, et al. Anxiety Disorders Among Patients With Co-occurring Bipolar and Substance Use Disorders. Drug Alcohol Depend. 2005 Nov 1;80(2):251-7. PubMed PMID: 15876498.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Anxiety disorders among patients with co-occurring bipolar and substance use disorders. AU - Kolodziej,Monika E, AU - Griffin,Margaret L, AU - Najavits,Lisa M, AU - Otto,Michael W, AU - Greenfield,Shelly F, AU - Weiss,Roger D, PY - 2004/07/30/received PY - 2005/04/06/revised PY - 2005/04/13/accepted PY - 2005/5/7/pubmed PY - 2006/2/25/medline PY - 2005/5/7/entrez SP - 251 EP - 7 JF - Drug and alcohol dependence JO - Drug Alcohol Depend VL - 80 IS - 2 N2 - Bipolar and substance use disorders are known to co-occur frequently, but limited attention has been paid to anxiety disorders that may accompany this dual diagnosis. Therefore, we examined the prevalence and nature of anxiety disorders among treatment-seeking patients diagnosed with current bipolar and substance use disorders, and investigated the association between anxiety disorders and substance use. Among 90 participants diagnosed with bipolar disorder I (n = 75, 78%) or II (n = 15, 22%), 43 (48%) had a lifetime anxiety disorder, with post-traumatic stress disorder (PTSD) occurring most frequently (n = 21, 23%). We found that those with PTSD, but not with the other anxiety disorders assessed, began using drugs at an earlier age and had more lifetime substance use disorders, particularly cocaine and amphetamine use disorders, than those without PTSD. Further examination revealed that (1) most participants with PTSD were women, (2) sexual abuse was the most frequently reported index trauma, and (3) the mean age of the earliest index trauma occurred before the mean age of initiation of drug use. Our findings point to the importance of further investigating the ramifications of a trauma history among those who are dually diagnosed with bipolar and substance use disorders. SN - 0376-8716 UR - https://www.unboundmedicine.com/medline/citation/15876498/Anxiety_disorders_among_patients_with_co_occurring_bipolar_and_substance_use_disorders_ DB - PRIME DP - Unbound Medicine ER -