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Blood pressure and dementia.
Panminerva Med. 2004 Dec; 46(4):227-37.PM

Abstract

Hypertension has proven to be a major predisposing factor for the development of both vascular and degenerative (Alzheimer's) dementias, either following stroke or gradually through more insidious microcerebrovascular processes. In the latter case the interval between the respective manifestations of hypertension and dementia may vary between a few years and several decades. The temporal relationships may become complicated by the finding that blood pressure tends to fall shortly before the onset of overt Alzheimers' disease. Whether or not timely antihypertensive regimens may delay or even prevent the development of dementias later in life is still an ''educated'' guess, as long there has been no comprehensive trial comparing the potential of the different antihypertensive drug classes in this regard. Until then, the class of dihydropyridine calcium antagonists (exemplified by nitrendipine in the Syst-Eur trial) is the only category having statistically been proven to be of substantial value for prevention of Alzheimer's disease.

Authors+Show Affiliations

Erasmus University, Rotterdam, the Netherlands.No affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

15876979

Citation

Birkenhäger, W H., and J A. Staessen. "Blood Pressure and Dementia." Panminerva Medica, vol. 46, no. 4, 2004, pp. 227-37.
Birkenhäger WH, Staessen JA. Blood pressure and dementia. Panminerva Med. 2004;46(4):227-37.
Birkenhäger, W. H., & Staessen, J. A. (2004). Blood pressure and dementia. Panminerva Medica, 46(4), 227-37.
Birkenhäger WH, Staessen JA. Blood Pressure and Dementia. Panminerva Med. 2004;46(4):227-37. PubMed PMID: 15876979.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Blood pressure and dementia. AU - Birkenhäger,W H, AU - Staessen,J A, PY - 2005/5/7/pubmed PY - 2005/6/14/medline PY - 2005/5/7/entrez SP - 227 EP - 37 JF - Panminerva medica JO - Panminerva Med VL - 46 IS - 4 N2 - Hypertension has proven to be a major predisposing factor for the development of both vascular and degenerative (Alzheimer's) dementias, either following stroke or gradually through more insidious microcerebrovascular processes. In the latter case the interval between the respective manifestations of hypertension and dementia may vary between a few years and several decades. The temporal relationships may become complicated by the finding that blood pressure tends to fall shortly before the onset of overt Alzheimers' disease. Whether or not timely antihypertensive regimens may delay or even prevent the development of dementias later in life is still an ''educated'' guess, as long there has been no comprehensive trial comparing the potential of the different antihypertensive drug classes in this regard. Until then, the class of dihydropyridine calcium antagonists (exemplified by nitrendipine in the Syst-Eur trial) is the only category having statistically been proven to be of substantial value for prevention of Alzheimer's disease. SN - 0031-0808 UR - https://www.unboundmedicine.com/medline/citation/15876979/Blood_pressure_and_dementia_ L2 - https://medlineplus.gov/dementia.html DB - PRIME DP - Unbound Medicine ER -