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Outcome and long-term growth after extensive small bowel resection in the neonatal period: a survey of 87 children.
Eur J Pediatr Surg. 2005 Apr; 15(2):95-101.EJ

Abstract

This retrospective study aims to analyze the outcome, the prognosis factors and the long-term growth of children after extensive small bowel (SB) resection in the neonatal period.

PATIENTS AND METHODS

87 children, born between 1975 and 1991 who had undergone extensive neonatal small bowel resection, were followed up over a mean period of 15 years. Anatomical data influencing PN dependency and duration were analyzed. Data on height and weight were collected and compared using growth standards. Final heights were studied for patients who achieved their puberty and compared to predicted height based on Tanner's formula. Patients were analyzed according to PN weaning and growth: children still receiving PN (group A), patients weaned from initial PN but requiring PN once again or enteral feeding (group B), and children with permanent intestinal autonomy (group C).

RESULTS

The overall survival is 89.7 %, depending on the date of birth. The duration of PN-dependency varies according to the intestinal length and the presence of the ileocaecal valve (ICV). All patients who remain PN dependent had less than 40 cm of small bowel and/or the absence of ICV. Patients in group B had a mean small bowel length of 35 +/- 19 cm, resection of the ICV in 50 % of cases, and a PN duration of 47.4 +/- 23.8 months. There was a significant decrease in height and weight gain within the 4 years after cessation of PN, requiring enteral or parenteral feeding. Patients in group C had a mean small bowel length of 57 +/- 19 cm, presence of ICV in 81 % of cases and a PN duration of 16.1 +/- 11.4 months. After PN weaning, they grow up normally with normal puberty and final height as predicted from genetic target height.

CONCLUSION

PN duration is influenced by the length of residual SB and the absence of ICV. With good anatomic prognosis factors and short duration of initial PN, normal long-term growth may be predicted. Conversely, poor anatomical factors and protracted initial PN require careful monitoring of growth and may sometimes require nutritional support to be restarted. The last group, permanently dependent on PN, might be candidates for intestinal transplantation.

Authors+Show Affiliations

Gastroenterology and Nutrition Department, Hôpital des Enfants-Malades, Paris, France. olivier.goulet@nck.ap-hop-paris.frNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15877257

Citation

Goulet, O, et al. "Outcome and Long-term Growth After Extensive Small Bowel Resection in the Neonatal Period: a Survey of 87 Children." European Journal of Pediatric Surgery : Official Journal of Austrian Association of Pediatric Surgery ... [et Al] = Zeitschrift Fur Kinderchirurgie, vol. 15, no. 2, 2005, pp. 95-101.
Goulet O, Baglin-Gobet S, Talbotec C, et al. Outcome and long-term growth after extensive small bowel resection in the neonatal period: a survey of 87 children. Eur J Pediatr Surg. 2005;15(2):95-101.
Goulet, O., Baglin-Gobet, S., Talbotec, C., Fourcade, L., Colomb, V., Sauvat, F., Jais, J. P., Michel, J. L., Jan, D., & Ricour, C. (2005). Outcome and long-term growth after extensive small bowel resection in the neonatal period: a survey of 87 children. European Journal of Pediatric Surgery : Official Journal of Austrian Association of Pediatric Surgery ... [et Al] = Zeitschrift Fur Kinderchirurgie, 15(2), 95-101.
Goulet O, et al. Outcome and Long-term Growth After Extensive Small Bowel Resection in the Neonatal Period: a Survey of 87 Children. Eur J Pediatr Surg. 2005;15(2):95-101. PubMed PMID: 15877257.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Outcome and long-term growth after extensive small bowel resection in the neonatal period: a survey of 87 children. AU - Goulet,O, AU - Baglin-Gobet,S, AU - Talbotec,C, AU - Fourcade,L, AU - Colomb,V, AU - Sauvat,F, AU - Jais,J-P, AU - Michel,J-L, AU - Jan,D, AU - Ricour,C, PY - 2005/5/7/pubmed PY - 2005/7/27/medline PY - 2005/5/7/entrez SP - 95 EP - 101 JF - European journal of pediatric surgery : official journal of Austrian Association of Pediatric Surgery ... [et al] = Zeitschrift fur Kinderchirurgie JO - Eur J Pediatr Surg VL - 15 IS - 2 N2 - UNLABELLED: This retrospective study aims to analyze the outcome, the prognosis factors and the long-term growth of children after extensive small bowel (SB) resection in the neonatal period. PATIENTS AND METHODS: 87 children, born between 1975 and 1991 who had undergone extensive neonatal small bowel resection, were followed up over a mean period of 15 years. Anatomical data influencing PN dependency and duration were analyzed. Data on height and weight were collected and compared using growth standards. Final heights were studied for patients who achieved their puberty and compared to predicted height based on Tanner's formula. Patients were analyzed according to PN weaning and growth: children still receiving PN (group A), patients weaned from initial PN but requiring PN once again or enteral feeding (group B), and children with permanent intestinal autonomy (group C). RESULTS: The overall survival is 89.7 %, depending on the date of birth. The duration of PN-dependency varies according to the intestinal length and the presence of the ileocaecal valve (ICV). All patients who remain PN dependent had less than 40 cm of small bowel and/or the absence of ICV. Patients in group B had a mean small bowel length of 35 +/- 19 cm, resection of the ICV in 50 % of cases, and a PN duration of 47.4 +/- 23.8 months. There was a significant decrease in height and weight gain within the 4 years after cessation of PN, requiring enteral or parenteral feeding. Patients in group C had a mean small bowel length of 57 +/- 19 cm, presence of ICV in 81 % of cases and a PN duration of 16.1 +/- 11.4 months. After PN weaning, they grow up normally with normal puberty and final height as predicted from genetic target height. CONCLUSION: PN duration is influenced by the length of residual SB and the absence of ICV. With good anatomic prognosis factors and short duration of initial PN, normal long-term growth may be predicted. Conversely, poor anatomical factors and protracted initial PN require careful monitoring of growth and may sometimes require nutritional support to be restarted. The last group, permanently dependent on PN, might be candidates for intestinal transplantation. SN - 0939-7248 UR - https://www.unboundmedicine.com/medline/citation/15877257/Outcome_and_long_term_growth_after_extensive_small_bowel_resection_in_the_neonatal_period:_a_survey_of_87_children_ L2 - http://www.thieme-connect.com/DOI/DOI?10.1055/s-2004-821214 DB - PRIME DP - Unbound Medicine ER -