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Chronic cytomegalovirus infection and inflammation are associated with prevalent frailty in community-dwelling older women.
J Am Geriatr Soc. 2005 May; 53(5):747-54.JA

Abstract

OBJECTIVES

To evaluate the association between asymptomatic chronic cytomegalovirus (CMV) infection and the frailty syndrome and to assess whether inflammation modifies this association.

DESIGN

Cross-sectional analysis.

SETTING

Women's Health and Aging Study I & II, Baltimore, Maryland.

PARTICIPANTS

Seven hundred twenty-four community-dwelling women aged 70 to 79 with baseline measures of CMV, interleukin-6 (IL-6), and frailty status.

MEASUREMENTS

CMV serology and IL-6 concentrations were measured using enzyme-linked immunosorbent assay. Frailty status was based on previously validated criteria: unintentional weight loss, weak grip strength, exhaustion, slow walking speed, and low level of activity. Frail women had three or more of the five components, prefrail women had one or two components, and women who were not frail had none of the components. Multinomial logistic regression adjusted for potential confounders.

RESULTS

Eighty-seven percent of women were CMV seropositive, an indication of chronic infection. CMV was associated with prevalent frailty, adjusting for age, smoking history, elevated body mass index, diabetes mellitus, and congestive heart failure (CMV frail adjusted odds ratio (AOR)=3.2, P=.03; CMV prefrail AOR=1.5, P=.18). IL-6 interacted with CMV, significantly increasing the magnitude of this association (CMV positive and low IL-6 frail AOR=1.5, P=.53; CMV positive and high IL-6 frail AOR=20.3, P=.007; CMV positive and low IL-6 prefrail AOR=0.9, P=.73; CMV positive and high IL-6 prefrail AOR=5.5, P=.001).

CONCLUSION

Chronic CMV infection is associated with prevalent frailty, a state with increased morbidity and mortality in older adults; inflammation enhances this effect. Further prospective studies are needed to establish a causal relationship between CMV, inflammation, and frailty.

Authors+Show Affiliations

Division of Geriatric Medicine, Department of Medicine, University of Calgary, Calgary, Alberta, Canada. heidi.schmaltz@calgaryhealthregion.caNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

15877548

Citation

Schmaltz, Heidi N., et al. "Chronic Cytomegalovirus Infection and Inflammation Are Associated With Prevalent Frailty in Community-dwelling Older Women." Journal of the American Geriatrics Society, vol. 53, no. 5, 2005, pp. 747-54.
Schmaltz HN, Fried LP, Xue QL, et al. Chronic cytomegalovirus infection and inflammation are associated with prevalent frailty in community-dwelling older women. J Am Geriatr Soc. 2005;53(5):747-54.
Schmaltz, H. N., Fried, L. P., Xue, Q. L., Walston, J., Leng, S. X., & Semba, R. D. (2005). Chronic cytomegalovirus infection and inflammation are associated with prevalent frailty in community-dwelling older women. Journal of the American Geriatrics Society, 53(5), 747-54.
Schmaltz HN, et al. Chronic Cytomegalovirus Infection and Inflammation Are Associated With Prevalent Frailty in Community-dwelling Older Women. J Am Geriatr Soc. 2005;53(5):747-54. PubMed PMID: 15877548.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Chronic cytomegalovirus infection and inflammation are associated with prevalent frailty in community-dwelling older women. AU - Schmaltz,Heidi N, AU - Fried,Linda P, AU - Xue,Qian-Li, AU - Walston,Jeremy, AU - Leng,Sean X, AU - Semba,Richard D, PY - 2005/5/10/pubmed PY - 2005/6/23/medline PY - 2005/5/10/entrez SP - 747 EP - 54 JF - Journal of the American Geriatrics Society JO - J Am Geriatr Soc VL - 53 IS - 5 N2 - OBJECTIVES: To evaluate the association between asymptomatic chronic cytomegalovirus (CMV) infection and the frailty syndrome and to assess whether inflammation modifies this association. DESIGN: Cross-sectional analysis. SETTING: Women's Health and Aging Study I & II, Baltimore, Maryland. PARTICIPANTS: Seven hundred twenty-four community-dwelling women aged 70 to 79 with baseline measures of CMV, interleukin-6 (IL-6), and frailty status. MEASUREMENTS: CMV serology and IL-6 concentrations were measured using enzyme-linked immunosorbent assay. Frailty status was based on previously validated criteria: unintentional weight loss, weak grip strength, exhaustion, slow walking speed, and low level of activity. Frail women had three or more of the five components, prefrail women had one or two components, and women who were not frail had none of the components. Multinomial logistic regression adjusted for potential confounders. RESULTS: Eighty-seven percent of women were CMV seropositive, an indication of chronic infection. CMV was associated with prevalent frailty, adjusting for age, smoking history, elevated body mass index, diabetes mellitus, and congestive heart failure (CMV frail adjusted odds ratio (AOR)=3.2, P=.03; CMV prefrail AOR=1.5, P=.18). IL-6 interacted with CMV, significantly increasing the magnitude of this association (CMV positive and low IL-6 frail AOR=1.5, P=.53; CMV positive and high IL-6 frail AOR=20.3, P=.007; CMV positive and low IL-6 prefrail AOR=0.9, P=.73; CMV positive and high IL-6 prefrail AOR=5.5, P=.001). CONCLUSION: Chronic CMV infection is associated with prevalent frailty, a state with increased morbidity and mortality in older adults; inflammation enhances this effect. Further prospective studies are needed to establish a causal relationship between CMV, inflammation, and frailty. SN - 0002-8614 UR - https://www.unboundmedicine.com/medline/citation/15877548/Chronic_cytomegalovirus_infection_and_inflammation_are_associated_with_prevalent_frailty_in_community_dwelling_older_women_ L2 - https://doi.org/10.1111/j.1532-5415.2005.53250.x DB - PRIME DP - Unbound Medicine ER -