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Insulin-sensitizing agents: use in pregnancy and as therapy in polycystic ovary syndrome.
Hum Reprod Update. 2005 Jul-Aug; 11(4):375-90.HR

Abstract

Treatment with insulin-sensitizing agents is a relatively recent therapeutic strategy in women with polycystic ovary syndrome (PCOS) and insulin resistance. The key areas addressed in this review include PCOS and the development of type 2 diabetes mellitus and gestational diabetes, as well as the use of insulin-sensitizing agents, particularly metformin, in the management of infertility in obese and non-obese PCOS women. Treatment with metformin in PCOS women undergoing IVF and the use of metformin during gestation will be discussed. The challenge for the health care professional should be the appropriate utilization of pharmacotherapies to improve insulin sensitivity and lower circulating insulin levels resulting in beneficial changes in PCOS phenotype. Further research into the potential role of other insulin-sensitizing agents, such as pioglitazone and rosiglitazone, in the treatment of infertile women with PCOS is needed.

Authors+Show Affiliations

Department of Obstetrics and Gynecology, Hospital Universitari del Mar, Universitat Autónoma de Barcelona, Barcelona, Spain. macheca@imas.imim.esNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

15878899

Citation

Checa, M A., et al. "Insulin-sensitizing Agents: Use in Pregnancy and as Therapy in Polycystic Ovary Syndrome." Human Reproduction Update, vol. 11, no. 4, 2005, pp. 375-90.
Checa MA, Requena A, Salvador C, et al. Insulin-sensitizing agents: use in pregnancy and as therapy in polycystic ovary syndrome. Hum Reprod Update. 2005;11(4):375-90.
Checa, M. A., Requena, A., Salvador, C., Tur, R., Callejo, J., Espinós, J. J., Fábregues, F., & Herrero, J. (2005). Insulin-sensitizing agents: use in pregnancy and as therapy in polycystic ovary syndrome. Human Reproduction Update, 11(4), 375-90.
Checa MA, et al. Insulin-sensitizing Agents: Use in Pregnancy and as Therapy in Polycystic Ovary Syndrome. Hum Reprod Update. 2005 Jul-Aug;11(4):375-90. PubMed PMID: 15878899.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Insulin-sensitizing agents: use in pregnancy and as therapy in polycystic ovary syndrome. AU - Checa,M A, AU - Requena,A, AU - Salvador,C, AU - Tur,R, AU - Callejo,J, AU - Espinós,J J, AU - Fábregues,F, AU - Herrero,J, AU - ,, Y1 - 2005/05/05/ PY - 2005/5/10/pubmed PY - 2005/9/8/medline PY - 2005/5/10/entrez SP - 375 EP - 90 JF - Human reproduction update JO - Hum Reprod Update VL - 11 IS - 4 N2 - Treatment with insulin-sensitizing agents is a relatively recent therapeutic strategy in women with polycystic ovary syndrome (PCOS) and insulin resistance. The key areas addressed in this review include PCOS and the development of type 2 diabetes mellitus and gestational diabetes, as well as the use of insulin-sensitizing agents, particularly metformin, in the management of infertility in obese and non-obese PCOS women. Treatment with metformin in PCOS women undergoing IVF and the use of metformin during gestation will be discussed. The challenge for the health care professional should be the appropriate utilization of pharmacotherapies to improve insulin sensitivity and lower circulating insulin levels resulting in beneficial changes in PCOS phenotype. Further research into the potential role of other insulin-sensitizing agents, such as pioglitazone and rosiglitazone, in the treatment of infertile women with PCOS is needed. SN - 1355-4786 UR - https://www.unboundmedicine.com/medline/citation/15878899/Insulin_sensitizing_agents:_use_in_pregnancy_and_as_therapy_in_polycystic_ovary_syndrome_ DB - PRIME DP - Unbound Medicine ER -