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The effects of cetrimide-chlorhexidine combination on the hepato-pancreatico-biliary system.
World J Surg 2005; 29(6):754-8WJ

Abstract

Sclerosing cholangitis is a rare but dreadful complication of liver hydatid surgery. Almost all scolocidal agents are associated clinically or experimentally with this complication. Cetrimide-chlorhexidine combination is the most potent scolocidal agent, and this study was designed to examine its effect on the hepato-pancreatico-biliary system. Forty Wistar-albino rats were divided into two groups. 0.5% cetrimide-0.05% chlorhexidine was injected into the biliary tract of study group animals and 0.9% saline (NaCl) into the control group through a 3-mm duodenotomy. The animals were sacrificed after 90 days and histopathological examination of the liver, biliary tract, and pancreas was performed 90 days after the biliary injection. The histopathological examination showed that the lesions ranged from focal necrosis to sclerosing cholangitis to liver cirrhosis. Focal necrosis and eosinophilic inflammation were observed in all rats in the study group. The changes in the liver, biliary tract, and pancreas of the study group animals were significantly more severe than those in the control group (p < 0.05). This experimental study confirms the deleterious effect of another scolocidal agents on the hepato-pancreatico-biliary system. Although it is a very effective scolocidal agent, it should not be used in the presence of a duct biliary-cyst communication.

Authors+Show Affiliations

Department of General Surgery, Ankara Numune Teaching and Research Hospital, Ankara, Turkey, 06140.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15880274

Citation

Tozar, Elvan, et al. "The Effects of Cetrimide-chlorhexidine Combination On the Hepato-pancreatico-biliary System." World Journal of Surgery, vol. 29, no. 6, 2005, pp. 754-8.
Tozar E, Topcu O, Karayalcin K, et al. The effects of cetrimide-chlorhexidine combination on the hepato-pancreatico-biliary system. World J Surg. 2005;29(6):754-8.
Tozar, E., Topcu, O., Karayalcin, K., Akbay, S. I., & Hengirmen, S. (2005). The effects of cetrimide-chlorhexidine combination on the hepato-pancreatico-biliary system. World Journal of Surgery, 29(6), pp. 754-8.
Tozar E, et al. The Effects of Cetrimide-chlorhexidine Combination On the Hepato-pancreatico-biliary System. World J Surg. 2005;29(6):754-8. PubMed PMID: 15880274.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effects of cetrimide-chlorhexidine combination on the hepato-pancreatico-biliary system. AU - Tozar,Elvan, AU - Topcu,Omer, AU - Karayalcin,Kaan, AU - Akbay,Serap Ilhan, AU - Hengirmen,Suleyman, PY - 2005/5/10/pubmed PY - 2005/12/13/medline PY - 2005/5/10/entrez SP - 754 EP - 8 JF - World journal of surgery JO - World J Surg VL - 29 IS - 6 N2 - Sclerosing cholangitis is a rare but dreadful complication of liver hydatid surgery. Almost all scolocidal agents are associated clinically or experimentally with this complication. Cetrimide-chlorhexidine combination is the most potent scolocidal agent, and this study was designed to examine its effect on the hepato-pancreatico-biliary system. Forty Wistar-albino rats were divided into two groups. 0.5% cetrimide-0.05% chlorhexidine was injected into the biliary tract of study group animals and 0.9% saline (NaCl) into the control group through a 3-mm duodenotomy. The animals were sacrificed after 90 days and histopathological examination of the liver, biliary tract, and pancreas was performed 90 days after the biliary injection. The histopathological examination showed that the lesions ranged from focal necrosis to sclerosing cholangitis to liver cirrhosis. Focal necrosis and eosinophilic inflammation were observed in all rats in the study group. The changes in the liver, biliary tract, and pancreas of the study group animals were significantly more severe than those in the control group (p < 0.05). This experimental study confirms the deleterious effect of another scolocidal agents on the hepato-pancreatico-biliary system. Although it is a very effective scolocidal agent, it should not be used in the presence of a duct biliary-cyst communication. SN - 0364-2313 UR - https://www.unboundmedicine.com/medline/citation/15880274/The_effects_of_cetrimide_chlorhexidine_combination_on_the_hepato_pancreatico_biliary_system_ L2 - https://dx.doi.org/10.1007/s00268-005-7782-4 DB - PRIME DP - Unbound Medicine ER -