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An international cohort study of cancer in systemic lupus erythematosus.
Arthritis Rheum 2005; 52(5):1481-90AR

Abstract

OBJECTIVE

There is increasing evidence in support of an association between systemic lupus erythematosus (SLE) and malignancy, but in earlier studies the association could not be quantified precisely. The present study was undertaken to ascertain the incidence of cancer in SLE patients, compared with that in the general population.

METHODS

We assembled a multisite (23 centers) international cohort of patients diagnosed as having SLE. Patients at each center were linked to regional tumor registries to determine cancer occurrence. Standardized incidence ratios (SIRs) were calculated as the ratio of observed to expected cancers. Cancers expected were determined by multiplying person-years in the cohort by the geographically matched age, sex, and calendar year-specific cancer rates, and summing over all person-years.

RESULTS

The 9,547 patients from 23 centers were observed for a total of 76,948 patient-years, with an average followup of 8 years. Within the observation interval, 431 cancers occurred. The data confirmed an increased risk of cancer among patients with SLE. For all cancers combined, the SIR estimate was 1.15 (95% confidence interval [95% CI] 1.05-1.27), for all hematologic malignancies, it was 2.75 (95% CI 2.13-3.49), and for non-Hodgkin's lymphoma, it was 3.64 (95% CI 2.63-4.93). The data also suggested an increased risk of lung cancer (SIR 1.37; 95% CI 1.05-1.76), and hepatobiliary cancer (SIR 2.60; 95% CI 1.25, 4.78).

CONCLUSION

These results support the notion of an association between SLE and cancer and more precisely define the risk of non-Hodgkin's lymphoma in SLE. It is not yet known whether this association is mediated by genetic factors or exogenous exposures.

Authors+Show Affiliations

Montreal General Hospital, Montreal, Quebec, Canada.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

15880596

Citation

Bernatsky, S, et al. "An International Cohort Study of Cancer in Systemic Lupus Erythematosus." Arthritis and Rheumatism, vol. 52, no. 5, 2005, pp. 1481-90.
Bernatsky S, Boivin JF, Joseph L, et al. An international cohort study of cancer in systemic lupus erythematosus. Arthritis Rheum. 2005;52(5):1481-90.
Bernatsky, S., Boivin, J. F., Joseph, L., Rajan, R., Zoma, A., Manzi, S., ... Clarke, A. (2005). An international cohort study of cancer in systemic lupus erythematosus. Arthritis and Rheumatism, 52(5), pp. 1481-90.
Bernatsky S, et al. An International Cohort Study of Cancer in Systemic Lupus Erythematosus. Arthritis Rheum. 2005;52(5):1481-90. PubMed PMID: 15880596.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - An international cohort study of cancer in systemic lupus erythematosus. AU - Bernatsky,S, AU - Boivin,J F, AU - Joseph,L, AU - Rajan,R, AU - Zoma,A, AU - Manzi,S, AU - Ginzler,E, AU - Urowitz,M, AU - Gladman,D, AU - Fortin,P R, AU - Petri,M, AU - Edworthy,S, AU - Barr,S, AU - Gordon,C, AU - Bae,S C, AU - Sibley,J, AU - Isenberg,D, AU - Rahman,A, AU - Aranow,C, AU - Dooley,M A, AU - Steinsson,K, AU - Nived,O, AU - Sturfelt,G, AU - Alarcón,G, AU - Senécal,J L, AU - Zummer,M, AU - Hanly,J, AU - Ensworth,S, AU - Pope,J, AU - El-Gabalawy,H, AU - McCarthy,T, AU - St Pierre,Y, AU - Ramsey-Goldman,R, AU - Clarke,A, PY - 2005/5/10/pubmed PY - 2005/6/30/medline PY - 2005/5/10/entrez SP - 1481 EP - 90 JF - Arthritis and rheumatism JO - Arthritis Rheum. VL - 52 IS - 5 N2 - OBJECTIVE: There is increasing evidence in support of an association between systemic lupus erythematosus (SLE) and malignancy, but in earlier studies the association could not be quantified precisely. The present study was undertaken to ascertain the incidence of cancer in SLE patients, compared with that in the general population. METHODS: We assembled a multisite (23 centers) international cohort of patients diagnosed as having SLE. Patients at each center were linked to regional tumor registries to determine cancer occurrence. Standardized incidence ratios (SIRs) were calculated as the ratio of observed to expected cancers. Cancers expected were determined by multiplying person-years in the cohort by the geographically matched age, sex, and calendar year-specific cancer rates, and summing over all person-years. RESULTS: The 9,547 patients from 23 centers were observed for a total of 76,948 patient-years, with an average followup of 8 years. Within the observation interval, 431 cancers occurred. The data confirmed an increased risk of cancer among patients with SLE. For all cancers combined, the SIR estimate was 1.15 (95% confidence interval [95% CI] 1.05-1.27), for all hematologic malignancies, it was 2.75 (95% CI 2.13-3.49), and for non-Hodgkin's lymphoma, it was 3.64 (95% CI 2.63-4.93). The data also suggested an increased risk of lung cancer (SIR 1.37; 95% CI 1.05-1.76), and hepatobiliary cancer (SIR 2.60; 95% CI 1.25, 4.78). CONCLUSION: These results support the notion of an association between SLE and cancer and more precisely define the risk of non-Hodgkin's lymphoma in SLE. It is not yet known whether this association is mediated by genetic factors or exogenous exposures. SN - 0004-3591 UR - https://www.unboundmedicine.com/medline/citation/15880596/An_international_cohort_study_of_cancer_in_systemic_lupus_erythematosus_ L2 - https://doi.org/10.1002/art.21029 DB - PRIME DP - Unbound Medicine ER -