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Six new sesquiterpenes from Cacalia ainsliaeflora.
Pharmazie. 2005 Apr; 60(4):313-6.P

Abstract

Five new eremophilane sesquiterpenes, 3beta,6beta-diangeloyloxy-8beta,10beta-dihydroxyeremophilenolide (1); 6beta-acetoxy-3beta-angeloyloxy-8beta,10beta-dihydroxyeremophilenolide (2); 3beta-angeloyloxy-6beta-methoxyeremophil-7(11),9(10)-dien-8alpha,12-olide (3), 3beta-angeloyloxy-8-oxo-eremophil-6(7)-en-12-oic acid (4); 3beta-angeloyloxy-10beta-hydroxy-8-oxo-eremophil-6(7)-en-12-oic acid (5), and a novel nor-eremophilane derivative, 3beta-angeloyloxy-10beta-hydroxy-8-oxo-eremophil-6(7)-en (6), were isolated from the roots of Cacalia ainsliaeflora. Their structures were elucidated by spectroscopic methods, including 2DNMR. Compounds 1 and 2 were assayed against P388 and A549 Carcinoma cell lines. No positive activities were observed.

Authors+Show Affiliations

Mao MJ
Department of Chemistry, Tongji University, 1239 Siping Road, Shanghai 200092, PR China. maomanj@yahoo.com.cn
Jiang B
No affiliation info available
Jia ZJ
No affiliation info available

MeSH

Antineoplastic Agents, PhytogenicDrug Screening Assays, AntitumorHumansIndicators and ReagentsMagnetic Resonance SpectroscopyPlant ExtractsPlant RootsPlants, MedicinalSesquiterpenesSpectrophotometry, Infrared

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15881615

Citation

Mao, Man-Jun, et al. "Six New Sesquiterpenes From Cacalia Ainsliaeflora." Die Pharmazie, vol. 60, no. 4, 2005, pp. 313-6.
Mao MJ, Jiang B, Jia ZJ. Six new sesquiterpenes from Cacalia ainsliaeflora. Pharmazie. 2005;60(4):313-6.
Mao, M. J., Jiang, B., & Jia, Z. J. (2005). Six new sesquiterpenes from Cacalia ainsliaeflora. Die Pharmazie, 60(4), 313-6.
Mao MJ, Jiang B, Jia ZJ. Six New Sesquiterpenes From Cacalia Ainsliaeflora. Pharmazie. 2005;60(4):313-6. PubMed PMID: 15881615.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Six new sesquiterpenes from Cacalia ainsliaeflora. AU - Mao,Man-Jun, AU - Jiang,Biao, AU - Jia,Zhong-Jian, PY - 2005/5/11/pubmed PY - 2005/6/1/medline PY - 2005/5/11/entrez SP - 313 EP - 6 JF - Die Pharmazie JO - Pharmazie VL - 60 IS - 4 N2 - Five new eremophilane sesquiterpenes, 3beta,6beta-diangeloyloxy-8beta,10beta-dihydroxyeremophilenolide (1); 6beta-acetoxy-3beta-angeloyloxy-8beta,10beta-dihydroxyeremophilenolide (2); 3beta-angeloyloxy-6beta-methoxyeremophil-7(11),9(10)-dien-8alpha,12-olide (3), 3beta-angeloyloxy-8-oxo-eremophil-6(7)-en-12-oic acid (4); 3beta-angeloyloxy-10beta-hydroxy-8-oxo-eremophil-6(7)-en-12-oic acid (5), and a novel nor-eremophilane derivative, 3beta-angeloyloxy-10beta-hydroxy-8-oxo-eremophil-6(7)-en (6), were isolated from the roots of Cacalia ainsliaeflora. Their structures were elucidated by spectroscopic methods, including 2DNMR. Compounds 1 and 2 were assayed against P388 and A549 Carcinoma cell lines. No positive activities were observed. SN - 0031-7144 UR - https://www.unboundmedicine.com/medline/citation/15881615/Six_new_sesquiterpenes_from_Cacalia_ainsliaeflora_ DB - PRIME DP - Unbound Medicine ER -