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Anticarcinogenic effect of Nymphaea alba against oxidative damage, hyperproliferative response and renal carcinogenesis in Wistar rats.
Mol Cell Biochem. 2005 Mar; 271(1-2):1-11.MC

Abstract

The present study investigates the prophylactic effect of Nymphaea alba against ferric nitrilotriacetate (Fe-NTA)-induced renal oxidative stress, hyperproliferative response and renal carcinogenesis in Wistar rats. Treatment with Fe-NTA (9 mg Fe/kg body weight, intraperitoneally) enhanced iron-ascorbate-induced renal lipid peroxidation, xanthine oxidase, gamma-glutamyl transpeptidase and hydrogen peroxide (H2O2) generation with reduction in renal glutathione content, antioxidant enzymes, viz., glutathione peroxidase, glutathione reductase, catalase, glucose-6-phosphate dehydrogenase and phase-II metabolising enzymes such as glutathione-S-transferase and quinone reductase. It also elevated the levels of blood urea nitrogen, serum creatinine, ornithine decarboxylase (ODC) activity and thymidine [3H] incorporation into renal DNA. It also enhanced DEN-initiated renal carcinogenesis by increasing the percentage incidence of renal tumors. Treatment of rats orally with N. alba (100 and 200 mg/kg body weight) resulted in significant decrease in gamma-glutamyl transpeptidase, lipid peroxidation, xanthine oxidase, H2O2 generation, blood urea nitrogen, serum creatinine, renal ODC activity, DNA synthesis (p < 0.001) and incidence of tumors. Renal glutathione content (p < 0.01), glutathione metabolizing enzymes (p < 0.001) and antioxidant enzymes were also recovered to significant level (p < 0.001). Thus, our results show that N. alba is a potent chemopreventive agent and suppresses Fe-NTA-induced oxidative stress, hyperproliferative response and renal carcinogenesis in Wistar rats.

Authors+Show Affiliations

Section of Chemoprevention and Nutrition Toxicology, Department of Medical Elementology and Toxicology, Faculty of Science, Jamia Hamdard, Hamdard University, New Delhi, India.No affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15881650

Citation

Khan, Naghma, and Sarwat Sultana. "Anticarcinogenic Effect of Nymphaea Alba Against Oxidative Damage, Hyperproliferative Response and Renal Carcinogenesis in Wistar Rats." Molecular and Cellular Biochemistry, vol. 271, no. 1-2, 2005, pp. 1-11.
Khan N, Sultana S. Anticarcinogenic effect of Nymphaea alba against oxidative damage, hyperproliferative response and renal carcinogenesis in Wistar rats. Mol Cell Biochem. 2005;271(1-2):1-11.
Khan, N., & Sultana, S. (2005). Anticarcinogenic effect of Nymphaea alba against oxidative damage, hyperproliferative response and renal carcinogenesis in Wistar rats. Molecular and Cellular Biochemistry, 271(1-2), 1-11.
Khan N, Sultana S. Anticarcinogenic Effect of Nymphaea Alba Against Oxidative Damage, Hyperproliferative Response and Renal Carcinogenesis in Wistar Rats. Mol Cell Biochem. 2005;271(1-2):1-11. PubMed PMID: 15881650.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Anticarcinogenic effect of Nymphaea alba against oxidative damage, hyperproliferative response and renal carcinogenesis in Wistar rats. AU - Khan,Naghma, AU - Sultana,Sarwat, PY - 2005/5/11/pubmed PY - 2005/8/24/medline PY - 2005/5/11/entrez SP - 1 EP - 11 JF - Molecular and cellular biochemistry JO - Mol Cell Biochem VL - 271 IS - 1-2 N2 - The present study investigates the prophylactic effect of Nymphaea alba against ferric nitrilotriacetate (Fe-NTA)-induced renal oxidative stress, hyperproliferative response and renal carcinogenesis in Wistar rats. Treatment with Fe-NTA (9 mg Fe/kg body weight, intraperitoneally) enhanced iron-ascorbate-induced renal lipid peroxidation, xanthine oxidase, gamma-glutamyl transpeptidase and hydrogen peroxide (H2O2) generation with reduction in renal glutathione content, antioxidant enzymes, viz., glutathione peroxidase, glutathione reductase, catalase, glucose-6-phosphate dehydrogenase and phase-II metabolising enzymes such as glutathione-S-transferase and quinone reductase. It also elevated the levels of blood urea nitrogen, serum creatinine, ornithine decarboxylase (ODC) activity and thymidine [3H] incorporation into renal DNA. It also enhanced DEN-initiated renal carcinogenesis by increasing the percentage incidence of renal tumors. Treatment of rats orally with N. alba (100 and 200 mg/kg body weight) resulted in significant decrease in gamma-glutamyl transpeptidase, lipid peroxidation, xanthine oxidase, H2O2 generation, blood urea nitrogen, serum creatinine, renal ODC activity, DNA synthesis (p < 0.001) and incidence of tumors. Renal glutathione content (p < 0.01), glutathione metabolizing enzymes (p < 0.001) and antioxidant enzymes were also recovered to significant level (p < 0.001). Thus, our results show that N. alba is a potent chemopreventive agent and suppresses Fe-NTA-induced oxidative stress, hyperproliferative response and renal carcinogenesis in Wistar rats. SN - 0300-8177 UR - https://www.unboundmedicine.com/medline/citation/15881650/Anticarcinogenic_effect_of_Nymphaea_alba_against_oxidative_damage_hyperproliferative_response_and_renal_carcinogenesis_in_Wistar_rats_ L2 - https://www.springerlink.com/openurl.asp?genre=article&amp;issn=0300-8177&amp;volume=271&amp;issue=1-2&amp;spage=1 DB - PRIME DP - Unbound Medicine ER -