Tags

Type your tag names separated by a space and hit enter

Evaluation of crosslinked chitosan hydrogel beads as a carrier for prolonged delivery of diclofenac sodium: in vitro and in vivo studies.
Boll Chim Farm. 2004 Dec; 143(10):359-64.BC

Abstract

Chitosan hydrogel beads containing diclofanac sodium were prepared using ionotropic gelation technique in which tripolyphosphate solution was used as a counterion. Chitosan molecular weight, tripolyphosphate concentration and crosslinking time were found to have an effect on the percentage of the drug loading. The loading efficiency of diclofenac sodium was very high (more than 90%). A longer-period of contact with the counterion ions decreased the efficiency of drug loading. The beads produced all had good spherical geometry. The beads showed a narrow size distribution in which 95% of the beads prepared were in the range of 2-3 mm. Comparison of release rate-time plots of dissolution data of marketed product with the newly developed dosage form indicated the ability of the later to sustain more diclofenac sodium release. The beads were evaluated for their bioavailability in six beagle dogs relative to the commercial enteric-coated Voltaren tablets. The in vivo availability study, reveled that the prepared beads filled in hard gelatin capsules had a 126.22% bioavailability relative to that of the commercial Voltaren tablets. The beads showed comparable pharmacokinetic parameters to that of the commercial tablets. The results suggested the possibility of producing a promising sustained drug delivery system for diclofenac sodium.

Authors+Show Affiliations

Department of Pharmaceutics, College of Pharmacy King Saud University, Riyadh, Saudi Arabia.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15881815

Citation

Alsarra, Ibrahim A.. "Evaluation of Crosslinked Chitosan Hydrogel Beads as a Carrier for Prolonged Delivery of Diclofenac Sodium: in Vitro and in Vivo Studies." Bollettino Chimico Farmaceutico, vol. 143, no. 10, 2004, pp. 359-64.
Alsarra IA. Evaluation of crosslinked chitosan hydrogel beads as a carrier for prolonged delivery of diclofenac sodium: in vitro and in vivo studies. Boll Chim Farm. 2004;143(10):359-64.
Alsarra, I. A. (2004). Evaluation of crosslinked chitosan hydrogel beads as a carrier for prolonged delivery of diclofenac sodium: in vitro and in vivo studies. Bollettino Chimico Farmaceutico, 143(10), 359-64.
Alsarra IA. Evaluation of Crosslinked Chitosan Hydrogel Beads as a Carrier for Prolonged Delivery of Diclofenac Sodium: in Vitro and in Vivo Studies. Boll Chim Farm. 2004;143(10):359-64. PubMed PMID: 15881815.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Evaluation of crosslinked chitosan hydrogel beads as a carrier for prolonged delivery of diclofenac sodium: in vitro and in vivo studies. A1 - Alsarra,Ibrahim A, PY - 2005/5/11/pubmed PY - 2005/6/29/medline PY - 2005/5/11/entrez SP - 359 EP - 64 JF - Bollettino chimico farmaceutico JO - Boll Chim Farm VL - 143 IS - 10 N2 - Chitosan hydrogel beads containing diclofanac sodium were prepared using ionotropic gelation technique in which tripolyphosphate solution was used as a counterion. Chitosan molecular weight, tripolyphosphate concentration and crosslinking time were found to have an effect on the percentage of the drug loading. The loading efficiency of diclofenac sodium was very high (more than 90%). A longer-period of contact with the counterion ions decreased the efficiency of drug loading. The beads produced all had good spherical geometry. The beads showed a narrow size distribution in which 95% of the beads prepared were in the range of 2-3 mm. Comparison of release rate-time plots of dissolution data of marketed product with the newly developed dosage form indicated the ability of the later to sustain more diclofenac sodium release. The beads were evaluated for their bioavailability in six beagle dogs relative to the commercial enteric-coated Voltaren tablets. The in vivo availability study, reveled that the prepared beads filled in hard gelatin capsules had a 126.22% bioavailability relative to that of the commercial Voltaren tablets. The beads showed comparable pharmacokinetic parameters to that of the commercial tablets. The results suggested the possibility of producing a promising sustained drug delivery system for diclofenac sodium. SN - 0006-6648 UR - https://www.unboundmedicine.com/medline/citation/15881815/Evaluation_of_crosslinked_chitosan_hydrogel_beads_as_a_carrier_for_prolonged_delivery_of_diclofenac_sodium:_in_vitro_and_in_vivo_studies_ DB - PRIME DP - Unbound Medicine ER -