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Distribution and correlates of arterial compliance measures in asymptomatic young adults: the Bogalusa Heart Study.
Am J Hypertens. 2005 May; 18(5 Pt 1):684-91.AJ

Abstract

BACKGROUND

Impaired arterial compliance is an independent predictor of early vascular damage and related adverse cardiovascular (CV) outcome. Information is scant on the distributions and correlates of measures of arterial pulsatile function in a community-based, biracial cohort of young adults.

METHODS

In 800 African American and white subjects aged 18 to 44 years, pulsatile arterial function was assessed in terms of large artery (capacitive) compliance, small artery (oscillatory) compliance, systemic vascular resistance, and vascular impedance by noninvasive radial artery pressure pulse contour analysis.

RESULTS

African Americans versus whites and women versus men had lower large and small artery compliances and higher systemic vascular resistance and vascular impedance (P < .001). In multiple regression analysis, mean arterial pressure, body mass index (BMI), insulin levels, and age were correlated inversely and body surface area positively with large artery compliance and accounted for 39.2% of the variance; mean arterial pressure, female gender, age, and triglyceride levels inversely and cardiac output positively with small artery compliance and explained 56.4% of the variance; mean arterial pressure and age positively and cardiac output inversely with systemic vascular resistance and accounted for 91.4% of variance; and mean arterial pressure and BMI positively and cardiac output and body surface area inversely with vascular impedance and contributed to 37.6% of the variance.

CONCLUSIONS

The observed deleterious impact of traditional CV risk factors on the arterial wall dynamics in asymptomatic young adults has important implications for preventive cardiology. Noninvasive pulsatile arterial function assessment may be helpful for evaluation of early vascular damage in a high-risk young population group.

Authors+Show Affiliations

Tulane Center for Cardiovascular Health, Tulane University Health Sciences Center, New Orleans, Louisiana 70112, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

15882552

Citation

Bhuiyan, Azad R., et al. "Distribution and Correlates of Arterial Compliance Measures in Asymptomatic Young Adults: the Bogalusa Heart Study." American Journal of Hypertension, vol. 18, no. 5 Pt 1, 2005, pp. 684-91.
Bhuiyan AR, Li S, Li H, et al. Distribution and correlates of arterial compliance measures in asymptomatic young adults: the Bogalusa Heart Study. Am J Hypertens. 2005;18(5 Pt 1):684-91.
Bhuiyan, A. R., Li, S., Li, H., Chen, W., Srinivasan, S. R., & Berenson, G. S. (2005). Distribution and correlates of arterial compliance measures in asymptomatic young adults: the Bogalusa Heart Study. American Journal of Hypertension, 18(5 Pt 1), 684-91.
Bhuiyan AR, et al. Distribution and Correlates of Arterial Compliance Measures in Asymptomatic Young Adults: the Bogalusa Heart Study. Am J Hypertens. 2005;18(5 Pt 1):684-91. PubMed PMID: 15882552.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Distribution and correlates of arterial compliance measures in asymptomatic young adults: the Bogalusa Heart Study. AU - Bhuiyan,Azad R, AU - Li,Shengxu, AU - Li,Hong, AU - Chen,Wei, AU - Srinivasan,Sathanur R, AU - Berenson,Gerald S, PY - 2004/08/06/received PY - 2004/11/19/revised PY - 2004/11/22/accepted PY - 2005/5/11/pubmed PY - 2005/7/29/medline PY - 2005/5/11/entrez SP - 684 EP - 91 JF - American journal of hypertension JO - Am J Hypertens VL - 18 IS - 5 Pt 1 N2 - BACKGROUND: Impaired arterial compliance is an independent predictor of early vascular damage and related adverse cardiovascular (CV) outcome. Information is scant on the distributions and correlates of measures of arterial pulsatile function in a community-based, biracial cohort of young adults. METHODS: In 800 African American and white subjects aged 18 to 44 years, pulsatile arterial function was assessed in terms of large artery (capacitive) compliance, small artery (oscillatory) compliance, systemic vascular resistance, and vascular impedance by noninvasive radial artery pressure pulse contour analysis. RESULTS: African Americans versus whites and women versus men had lower large and small artery compliances and higher systemic vascular resistance and vascular impedance (P < .001). In multiple regression analysis, mean arterial pressure, body mass index (BMI), insulin levels, and age were correlated inversely and body surface area positively with large artery compliance and accounted for 39.2% of the variance; mean arterial pressure, female gender, age, and triglyceride levels inversely and cardiac output positively with small artery compliance and explained 56.4% of the variance; mean arterial pressure and age positively and cardiac output inversely with systemic vascular resistance and accounted for 91.4% of variance; and mean arterial pressure and BMI positively and cardiac output and body surface area inversely with vascular impedance and contributed to 37.6% of the variance. CONCLUSIONS: The observed deleterious impact of traditional CV risk factors on the arterial wall dynamics in asymptomatic young adults has important implications for preventive cardiology. Noninvasive pulsatile arterial function assessment may be helpful for evaluation of early vascular damage in a high-risk young population group. SN - 0895-7061 UR - https://www.unboundmedicine.com/medline/citation/15882552/Distribution_and_correlates_of_arterial_compliance_measures_in_asymptomatic_young_adults:_the_Bogalusa_Heart_Study_ L2 - https://academic.oup.com/ajh/article-lookup/doi/10.1016/j.amjhyper.2004.11.039 DB - PRIME DP - Unbound Medicine ER -