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Prostate-specific antigen screening in a high-risk population: lessons from the community and how they relate to large-scale population-based studies.
Urology. 2005 May; 65(5):931-6.U

Abstract

OBJECTIVES

To estimate the incidence of prostate cancer among African-American men and Caribbean immigrants to the United States, to assess the applicability of large-scale prostate screening trials to a community screening program, and to recruit unscreened men.

METHODS

African-American and Caribbean-American men were targeted with a community-based prostate cancer screening program in Jamaica, New York. Serum prostate-specific antigen determination and digital rectal examination were used to determine abnormal findings. The incidence of an abnormal screening examination was used to project the incidence of prostate cancer, which was compared with that in other reported trials.

RESULTS

The projected incidence of prostate cancer among African-Americans and Caribbean-Americans older than 50 years was 8% and 7%, respectively, similar to that reported in other trials of African-American men. The projected incidence of prostate cancer in Caribbean-American men aged 40 to 49 years was 1%, the same as the high rate reported among Caribbean men. As in other trials, a family history of prostate cancer and age were strong predictors of abnormal findings. Of the recruited men older than 50 years, 58% had never been screened compared with 42% nationally.

CONCLUSIONS

Large population-based screening trials have identified ethnic groups at high risk of prostate cancer. This trial detected high rates of abnormal screening findings by targeting ethnicity. The incidence of an abnormal examination was high in Caribbean-American men younger than 50 years old. Finally, this trial successfully recruited underscreened men.

Authors+Show Affiliations

Department of Urology, Cornell University Weill Medical College and New York Presbyterian Hospital, New York, New York 10021, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15882726

Citation

Shelton, Jeremy B., et al. "Prostate-specific Antigen Screening in a High-risk Population: Lessons From the Community and How They Relate to Large-scale Population-based Studies." Urology, vol. 65, no. 5, 2005, pp. 931-6.
Shelton JB, Barocas DA, Conway F, et al. Prostate-specific antigen screening in a high-risk population: lessons from the community and how they relate to large-scale population-based studies. Urology. 2005;65(5):931-6.
Shelton, J. B., Barocas, D. A., Conway, F., Hart, K., Nelson, K., Richstone, L., Gonzalez, R. R., Raman, J. D., & Scherr, D. S. (2005). Prostate-specific antigen screening in a high-risk population: lessons from the community and how they relate to large-scale population-based studies. Urology, 65(5), 931-6.
Shelton JB, et al. Prostate-specific Antigen Screening in a High-risk Population: Lessons From the Community and How They Relate to Large-scale Population-based Studies. Urology. 2005;65(5):931-6. PubMed PMID: 15882726.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prostate-specific antigen screening in a high-risk population: lessons from the community and how they relate to large-scale population-based studies. AU - Shelton,Jeremy B, AU - Barocas,Daniel A, AU - Conway,Frances, AU - Hart,Kathleen, AU - Nelson,Kinloch, AU - Richstone,Lee, AU - Gonzalez,Ricardo R, AU - Raman,Jay D, AU - Scherr,Douglas S, PY - 2004/08/25/received PY - 2004/11/03/revised PY - 2004/11/30/accepted PY - 2005/5/11/pubmed PY - 2005/12/13/medline PY - 2005/5/11/entrez SP - 931 EP - 6 JF - Urology JO - Urology VL - 65 IS - 5 N2 - OBJECTIVES: To estimate the incidence of prostate cancer among African-American men and Caribbean immigrants to the United States, to assess the applicability of large-scale prostate screening trials to a community screening program, and to recruit unscreened men. METHODS: African-American and Caribbean-American men were targeted with a community-based prostate cancer screening program in Jamaica, New York. Serum prostate-specific antigen determination and digital rectal examination were used to determine abnormal findings. The incidence of an abnormal screening examination was used to project the incidence of prostate cancer, which was compared with that in other reported trials. RESULTS: The projected incidence of prostate cancer among African-Americans and Caribbean-Americans older than 50 years was 8% and 7%, respectively, similar to that reported in other trials of African-American men. The projected incidence of prostate cancer in Caribbean-American men aged 40 to 49 years was 1%, the same as the high rate reported among Caribbean men. As in other trials, a family history of prostate cancer and age were strong predictors of abnormal findings. Of the recruited men older than 50 years, 58% had never been screened compared with 42% nationally. CONCLUSIONS: Large population-based screening trials have identified ethnic groups at high risk of prostate cancer. This trial detected high rates of abnormal screening findings by targeting ethnicity. The incidence of an abnormal examination was high in Caribbean-American men younger than 50 years old. Finally, this trial successfully recruited underscreened men. SN - 1527-9995 UR - https://www.unboundmedicine.com/medline/citation/15882726/Prostate_specific_antigen_screening_in_a_high_risk_population:_lessons_from_the_community_and_how_they_relate_to_large_scale_population_based_studies_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0090-4295(04)01415-3 DB - PRIME DP - Unbound Medicine ER -