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A prospective study of physical activity and incident and fatal prostate cancer.

Abstract

BACKGROUND

Whether physical activity has benefits against prostate cancer incidence or progression is unclear. Therefore, we assessed physical activity in relation to prostate cancer incidence, mortality, and Gleason histologic grade.

METHODS

We used data from the Health Professionals Follow-up Study, a prospective cohort study, to determine the number of cases of incident, advanced (seminal vesicle invasion, metastasis, or fatal), fatal, and high-grade prostate cancer in a cohort of 47,620 US male health professionals, followed up from February 1, 1986, to January 31, 2000.

RESULTS

During 14 years of follow-up, we documented 2892 new cases of prostate cancer, including 482 advanced cases (280 of which were fatal). For total prostate cancer, no association was observed for total, vigorous, and nonvigorous physical activity. In men 65 years or older, we observed a lower risk in the highest category of vigorous activity for advanced (multivariable relative risk, 0.33; 95% confidence interval, 0.17-0.62, for more than 29 vs 0 metabolic equivalent hours) and for fatal (relative risk, 0.26; 95% confidence interval, 0.11-0.66) prostate cancer. No associations were observed in younger men. Differential screening by prostate-specific antigen or a reduction in physical activity due to undiagnosed prostate cancer did not appear to account for the results. Among cases, men with high levels of physical activity were less likely to be diagnosed with poorly differentiated cancers (Gleason grade > or = 7).

CONCLUSION

Although the mechanisms are not yet understood, these findings suggest that regular vigorous activity could slow the progression of prostate cancer and might be recommended to reduce mortality from prostate cancer, particularly given the many other documented benefits of exercise.

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  • Authors+Show Affiliations

    ,

    Department of Nutrition, Harvard School of Public Health, Boston, Mass, USA. edward.giovannucci@channing.harvard.edu

    , , ,

    Source

    Archives of internal medicine 165:9 2005 May 09 pg 1005-10

    MeSH

    Adult
    Age Factors
    Aged
    Exercise
    Follow-Up Studies
    Health Personnel
    Health Surveys
    Humans
    Incidence
    Life Style
    Male
    Middle Aged
    Prospective Studies
    Prostatic Neoplasms
    Survival Rate
    United States

    Pub Type(s)

    Journal Article
    Research Support, N.I.H., Extramural
    Research Support, U.S. Gov't, P.H.S.

    Language

    eng

    PubMed ID

    15883238

    Citation

    Giovannucci, Edward L., et al. "A Prospective Study of Physical Activity and Incident and Fatal Prostate Cancer." Archives of Internal Medicine, vol. 165, no. 9, 2005, pp. 1005-10.
    Giovannucci EL, Liu Y, Leitzmann MF, et al. A prospective study of physical activity and incident and fatal prostate cancer. Arch Intern Med. 2005;165(9):1005-10.
    Giovannucci, E. L., Liu, Y., Leitzmann, M. F., Stampfer, M. J., & Willett, W. C. (2005). A prospective study of physical activity and incident and fatal prostate cancer. Archives of Internal Medicine, 165(9), pp. 1005-10.
    Giovannucci EL, et al. A Prospective Study of Physical Activity and Incident and Fatal Prostate Cancer. Arch Intern Med. 2005 May 9;165(9):1005-10. PubMed PMID: 15883238.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - A prospective study of physical activity and incident and fatal prostate cancer. AU - Giovannucci,Edward L, AU - Liu,Yan, AU - Leitzmann,Michael F, AU - Stampfer,Meir J, AU - Willett,Walter C, PY - 2005/5/11/pubmed PY - 2005/6/9/medline PY - 2005/5/11/entrez SP - 1005 EP - 10 JF - Archives of internal medicine JO - Arch. Intern. Med. VL - 165 IS - 9 N2 - BACKGROUND: Whether physical activity has benefits against prostate cancer incidence or progression is unclear. Therefore, we assessed physical activity in relation to prostate cancer incidence, mortality, and Gleason histologic grade. METHODS: We used data from the Health Professionals Follow-up Study, a prospective cohort study, to determine the number of cases of incident, advanced (seminal vesicle invasion, metastasis, or fatal), fatal, and high-grade prostate cancer in a cohort of 47,620 US male health professionals, followed up from February 1, 1986, to January 31, 2000. RESULTS: During 14 years of follow-up, we documented 2892 new cases of prostate cancer, including 482 advanced cases (280 of which were fatal). For total prostate cancer, no association was observed for total, vigorous, and nonvigorous physical activity. In men 65 years or older, we observed a lower risk in the highest category of vigorous activity for advanced (multivariable relative risk, 0.33; 95% confidence interval, 0.17-0.62, for more than 29 vs 0 metabolic equivalent hours) and for fatal (relative risk, 0.26; 95% confidence interval, 0.11-0.66) prostate cancer. No associations were observed in younger men. Differential screening by prostate-specific antigen or a reduction in physical activity due to undiagnosed prostate cancer did not appear to account for the results. Among cases, men with high levels of physical activity were less likely to be diagnosed with poorly differentiated cancers (Gleason grade > or = 7). CONCLUSION: Although the mechanisms are not yet understood, these findings suggest that regular vigorous activity could slow the progression of prostate cancer and might be recommended to reduce mortality from prostate cancer, particularly given the many other documented benefits of exercise. SN - 0003-9926 UR - https://www.unboundmedicine.com/medline/citation/15883238/full_citation L2 - https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/10.1001/archinte.165.9.1005 DB - PRIME DP - Unbound Medicine ER -