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MRI predictors of risk of incident Alzheimer disease: a longitudinal study.
Neurology. 2005 May 10; 64(9):1520-4.Neur

Abstract

OBJECTIVE

To determine if baseline entorhinal and hippocampal volumes and their rate of atrophy could predict the risk of incident Alzheimer disease (AD).

METHODS

The authors used proportional odds models to assess the relationship between entorhinal and hippocampal size and risk of incident AD among 58 nondemented elderly people. All participants were followed with annual clinical evaluations and structural MRI scans for up to 5 years (baseline and 5 years of follow-up). At baseline, 23 of 58 participants received a diagnosis of amnestic mild cognitive impairment (MCI) and 35 of 58 were healthy control subjects with no cognitive impairment. Structural MRI scans were acquired with a T1-weighted three-dimensional spoiled gradient-recalled echo pulse sequence in a 1.5 T scanner. Entorhinal and hippocampal volumes were derived from 1.6-mm gapless coronal images reformatted to be perpendicular to the long axis of the hippocampus and were normalized by dividing with intracranial volume.

RESULTS

Fourteen of 58 nondemented participants developed AD during the follow-up period. Initial diagnosis of MCI was a significant predictor of incident AD. In addition, both baseline entorhinal volume and its slope of decline were independent predictors of incident AD, but initial hippocampal size and its rate of decline were not, after controlling for entorhinal volume.

CONCLUSION

In nondemented individuals, entorhinal cortex atrophy is associated with risk of Alzheimer disease.

Authors+Show Affiliations

Department of Neurologic Sciences, Rush University Medical Center, Chicago, IL, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

15883311

Citation

Stoub, T R., et al. "MRI Predictors of Risk of Incident Alzheimer Disease: a Longitudinal Study." Neurology, vol. 64, no. 9, 2005, pp. 1520-4.
Stoub TR, Bulgakova M, Leurgans S, et al. MRI predictors of risk of incident Alzheimer disease: a longitudinal study. Neurology. 2005;64(9):1520-4.
Stoub, T. R., Bulgakova, M., Leurgans, S., Bennett, D. A., Fleischman, D., Turner, D. A., & deToledo-Morrell, L. (2005). MRI predictors of risk of incident Alzheimer disease: a longitudinal study. Neurology, 64(9), 1520-4.
Stoub TR, et al. MRI Predictors of Risk of Incident Alzheimer Disease: a Longitudinal Study. Neurology. 2005 May 10;64(9):1520-4. PubMed PMID: 15883311.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - MRI predictors of risk of incident Alzheimer disease: a longitudinal study. AU - Stoub,T R, AU - Bulgakova,M, AU - Leurgans,S, AU - Bennett,D A, AU - Fleischman,D, AU - Turner,D A, AU - deToledo-Morrell,L, PY - 2005/5/11/pubmed PY - 2006/1/7/medline PY - 2005/5/11/entrez SP - 1520 EP - 4 JF - Neurology JO - Neurology VL - 64 IS - 9 N2 - OBJECTIVE: To determine if baseline entorhinal and hippocampal volumes and their rate of atrophy could predict the risk of incident Alzheimer disease (AD). METHODS: The authors used proportional odds models to assess the relationship between entorhinal and hippocampal size and risk of incident AD among 58 nondemented elderly people. All participants were followed with annual clinical evaluations and structural MRI scans for up to 5 years (baseline and 5 years of follow-up). At baseline, 23 of 58 participants received a diagnosis of amnestic mild cognitive impairment (MCI) and 35 of 58 were healthy control subjects with no cognitive impairment. Structural MRI scans were acquired with a T1-weighted three-dimensional spoiled gradient-recalled echo pulse sequence in a 1.5 T scanner. Entorhinal and hippocampal volumes were derived from 1.6-mm gapless coronal images reformatted to be perpendicular to the long axis of the hippocampus and were normalized by dividing with intracranial volume. RESULTS: Fourteen of 58 nondemented participants developed AD during the follow-up period. Initial diagnosis of MCI was a significant predictor of incident AD. In addition, both baseline entorhinal volume and its slope of decline were independent predictors of incident AD, but initial hippocampal size and its rate of decline were not, after controlling for entorhinal volume. CONCLUSION: In nondemented individuals, entorhinal cortex atrophy is associated with risk of Alzheimer disease. SN - 1526-632X UR - https://www.unboundmedicine.com/medline/citation/15883311/MRI_predictors_of_risk_of_incident_Alzheimer_disease:_a_longitudinal_study_ L2 - http://www.neurology.org/cgi/pmidlookup?view=long&pmid=15883311 DB - PRIME DP - Unbound Medicine ER -