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Incidence and etiology of dementia in a large elderly Italian population.
Neurology. 2005 May 10; 64(9):1525-30.Neur

Abstract

OBJECTIVE

To estimate age- and sex-specific incidence of dementia, Alzheimer disease (AD), and vascular dementia (VaD) in the Conselice Study of Brain Aging, an Italian prospective population-based study, and to assess whether poor education is a risk factor for dementia.

METHODS

In 1999 to 2000, the baseline study identified a dementia-free cohort of 937 subjects aged 65 years and older who were reexamined in 2003 to 2004 using a two-phase procedure.

RESULTS

Information was obtained for 91% of the subjects at risk; 115 incident cases of dementia were identified. Incidence rates per 1,000 person-years were 37.8 (95% CI = 30.0 to 47.7) for dementia, 23.8 (95% CI = 17.3 to 31.7) for AD, and 11.0 (95% CI = 7.2 to 16.9) for VaD. This translates into more than 400,000 new cases of dementia expected per year in Italy. Increasing age was an independent risk factor for both AD and VaD. Poor education was an independent risk factor for AD but not VaD. Sex did not affect dementia risk.

CONCLUSIONS

In this Italian population-based cohort, incidence of dementia increased with age, and Alzheimer disease (AD) was the most frequent type of dementia. Poor education was associated with a higher risk of AD. Our incidence rates are higher than previously reported in Italy, and provide new estimates for projection of future burden of disease in Italy.

Authors+Show Affiliations

Department of Internal Medicine, Cardioangiology, and Hepatology, University Hospital S. Orsola-Malpighi, Via Massarenti, 9-40138 Bologna, Italy. ravaglia@med.unibo.itNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15883312

Citation

Ravaglia, G, et al. "Incidence and Etiology of Dementia in a Large Elderly Italian Population." Neurology, vol. 64, no. 9, 2005, pp. 1525-30.
Ravaglia G, Forti P, Maioli F, et al. Incidence and etiology of dementia in a large elderly Italian population. Neurology. 2005;64(9):1525-30.
Ravaglia, G., Forti, P., Maioli, F., Martelli, M., Servadei, L., Brunetti, N., Dalmonte, E., Bianchin, M., & Mariani, E. (2005). Incidence and etiology of dementia in a large elderly Italian population. Neurology, 64(9), 1525-30.
Ravaglia G, et al. Incidence and Etiology of Dementia in a Large Elderly Italian Population. Neurology. 2005 May 10;64(9):1525-30. PubMed PMID: 15883312.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Incidence and etiology of dementia in a large elderly Italian population. AU - Ravaglia,G, AU - Forti,P, AU - Maioli,F, AU - Martelli,M, AU - Servadei,L, AU - Brunetti,N, AU - Dalmonte,E, AU - Bianchin,M, AU - Mariani,E, PY - 2005/5/11/pubmed PY - 2006/1/7/medline PY - 2005/5/11/entrez SP - 1525 EP - 30 JF - Neurology JO - Neurology VL - 64 IS - 9 N2 - OBJECTIVE: To estimate age- and sex-specific incidence of dementia, Alzheimer disease (AD), and vascular dementia (VaD) in the Conselice Study of Brain Aging, an Italian prospective population-based study, and to assess whether poor education is a risk factor for dementia. METHODS: In 1999 to 2000, the baseline study identified a dementia-free cohort of 937 subjects aged 65 years and older who were reexamined in 2003 to 2004 using a two-phase procedure. RESULTS: Information was obtained for 91% of the subjects at risk; 115 incident cases of dementia were identified. Incidence rates per 1,000 person-years were 37.8 (95% CI = 30.0 to 47.7) for dementia, 23.8 (95% CI = 17.3 to 31.7) for AD, and 11.0 (95% CI = 7.2 to 16.9) for VaD. This translates into more than 400,000 new cases of dementia expected per year in Italy. Increasing age was an independent risk factor for both AD and VaD. Poor education was an independent risk factor for AD but not VaD. Sex did not affect dementia risk. CONCLUSIONS: In this Italian population-based cohort, incidence of dementia increased with age, and Alzheimer disease (AD) was the most frequent type of dementia. Poor education was associated with a higher risk of AD. Our incidence rates are higher than previously reported in Italy, and provide new estimates for projection of future burden of disease in Italy. SN - 1526-632X UR - https://www.unboundmedicine.com/medline/citation/15883312/Incidence_and_etiology_of_dementia_in_a_large_elderly_Italian_population_ L2 - http://www.neurology.org/cgi/pmidlookup?view=long&pmid=15883312 DB - PRIME DP - Unbound Medicine ER -