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Relationship among fatness, blood lipids, and insulin resistance in Pakistani children.
J Health Popul Nutr. 2005 Mar; 23(1):34-43.JH

Abstract

Observations on associations between fatness and metabolic risks among South-East Asian adults have resulted in devising lower thresholds of body mass index (BMI) for them. Metabolic abnormalities, including type 2 diabetes, are now also appearing in children and are associated with obesity. There has not been much work done to identify indicators of metabolic risks among South Asian children. This study was undertaken to observe the relationship among fatness, blood lipids, and insulin resistance in Pakistani children. Fatness, lipids, and insulin resistance were assessed in 92 middle-class Pakistani school children aged 8-10 years. Height, weight, waist, hips, mid-arm circumference, and triceps skin-fold, measured in school, were used for calculating various indicators of fatness, i.e. BMI, waist hip ratio (WHR), and arm-fat percentage. Fasting blood samples were analyzed for total lipids, triglycerides (TG), total cholesterol (TC), high density lipoprotein (HDL), low density lipoprotein (LDL), glucose and insulin levels. Homeostasis model assessment (HOMA) index was calculated to assess insulin resistance. Two separate multiple regression models of various risk indicators (family history, sex, BMI, WHR, arm-fat percentage) showed that only arm-fat percentage had a significant positive association both with insulin levels (b = 2.04, p = 0.044) and LDL (b = 2.11, p = 0.037). Only five children were overweight (BMI-for-age > 85th percentile according to National Center for Health Statistics 2000 reference). Neither overweight children nor those who were in the uppermost tercile of BMI-for-age differed significantly from other children in terms of presence of higher-than-desirable values of lipids or insulin. However, compared to those in the lowest tercile, children who were in the uppermost tercile of armfat percentage had a significantly higher frequency of high blood cholesterol (40% vs 67%, p = 0.027), high LDL (33.3% vs 61.3%, p = 0.026), and markedly higher proportion above average insulin levels (16.7% vs 35.5%, p = 0.083). Arm-fat percentage could be developed as a practical tool for determining the risk status of children. However, further cross-sectional assessments are needed to ascertain accurate relationships among arm-fat percentage, lipid profiles, and insulin resistance in larger and varied groups of children.

Authors+Show Affiliations

Baqai Institute of Diabetology and Endocrinology, Baqai Medical University, Karachi, Pakistan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15884750

Citation

Basit, Abdul, et al. "Relationship Among Fatness, Blood Lipids, and Insulin Resistance in Pakistani Children." Journal of Health, Population, and Nutrition, vol. 23, no. 1, 2005, pp. 34-43.
Basit A, Hakeem R, Hydrie MZ, et al. Relationship among fatness, blood lipids, and insulin resistance in Pakistani children. J Health Popul Nutr. 2005;23(1):34-43.
Basit, A., Hakeem, R., Hydrie, M. Z., Ahmedani, M. Y., & Masood, Q. (2005). Relationship among fatness, blood lipids, and insulin resistance in Pakistani children. Journal of Health, Population, and Nutrition, 23(1), 34-43.
Basit A, et al. Relationship Among Fatness, Blood Lipids, and Insulin Resistance in Pakistani Children. J Health Popul Nutr. 2005;23(1):34-43. PubMed PMID: 15884750.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Relationship among fatness, blood lipids, and insulin resistance in Pakistani children. AU - Basit,Abdul, AU - Hakeem,Rubina, AU - Hydrie,M Zafar Iqbal, AU - Ahmedani,M Yakoob, AU - Masood,Qamar, PY - 2005/5/12/pubmed PY - 2005/6/2/medline PY - 2005/5/12/entrez SP - 34 EP - 43 JF - Journal of health, population, and nutrition JO - J Health Popul Nutr VL - 23 IS - 1 N2 - Observations on associations between fatness and metabolic risks among South-East Asian adults have resulted in devising lower thresholds of body mass index (BMI) for them. Metabolic abnormalities, including type 2 diabetes, are now also appearing in children and are associated with obesity. There has not been much work done to identify indicators of metabolic risks among South Asian children. This study was undertaken to observe the relationship among fatness, blood lipids, and insulin resistance in Pakistani children. Fatness, lipids, and insulin resistance were assessed in 92 middle-class Pakistani school children aged 8-10 years. Height, weight, waist, hips, mid-arm circumference, and triceps skin-fold, measured in school, were used for calculating various indicators of fatness, i.e. BMI, waist hip ratio (WHR), and arm-fat percentage. Fasting blood samples were analyzed for total lipids, triglycerides (TG), total cholesterol (TC), high density lipoprotein (HDL), low density lipoprotein (LDL), glucose and insulin levels. Homeostasis model assessment (HOMA) index was calculated to assess insulin resistance. Two separate multiple regression models of various risk indicators (family history, sex, BMI, WHR, arm-fat percentage) showed that only arm-fat percentage had a significant positive association both with insulin levels (b = 2.04, p = 0.044) and LDL (b = 2.11, p = 0.037). Only five children were overweight (BMI-for-age > 85th percentile according to National Center for Health Statistics 2000 reference). Neither overweight children nor those who were in the uppermost tercile of BMI-for-age differed significantly from other children in terms of presence of higher-than-desirable values of lipids or insulin. However, compared to those in the lowest tercile, children who were in the uppermost tercile of armfat percentage had a significantly higher frequency of high blood cholesterol (40% vs 67%, p = 0.027), high LDL (33.3% vs 61.3%, p = 0.026), and markedly higher proportion above average insulin levels (16.7% vs 35.5%, p = 0.083). Arm-fat percentage could be developed as a practical tool for determining the risk status of children. However, further cross-sectional assessments are needed to ascertain accurate relationships among arm-fat percentage, lipid profiles, and insulin resistance in larger and varied groups of children. SN - 1606-0997 UR - https://www.unboundmedicine.com/medline/citation/15884750/Relationship_among_fatness_blood_lipids_and_insulin_resistance_in_Pakistani_children_ L2 - https://medlineplus.gov/obesity.html DB - PRIME DP - Unbound Medicine ER -