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In vivo comparison of various liposome formulations for cosmetic application.
Int J Pharm. 2005 May 30; 296(1-2):44-54.IJ

Abstract

The interaction of liposome formulations, prepared with phospholipids of different origins (egg and soya), with skin were compared in terms of their effects on skin water content, skin barrier function, and skin elasticity. Short-term effect of four different liposome formulations and two references during 3.5 h was investigated non-occlusively on the volar side of the forearm of 10 volunteers, ranging in age from 24 to 32 years. Liposomes composed of different phospholipids showed differing effects on skin humidity. The maximal effect was achieved within 30 min and constant values were reached after 1.5 h for all formulations, however values remained significantly higher than without treatment (p<0.05) during the whole application time. The best results were obtained with liposome formulations prepared from egg phospholipids, which exhibited a 1.5-fold increase in skin water content (p<0.05), whereas liposome formulations prepared from soya phospholipids showed no advantage compared to the references. Skin barrier function showed greatest influence within 30 min after application and remained constant after 1.5 h for all formulations. Within the liposome formulations, egg phospholipids showed the highest transepidermal water loss values during the first 30 min, representing the strongest interactions with the skin barrier function, whereas for the other liposome formulations lower transepidermal water loss values were measured. Skin elasticity and tiring effect of the skin was not influenced by any of the formulations, due to the young skin tested. Long-term effect of two different liposome formulations mixed with base cream DAC in two different concentrations during 14 days was investigated non-occlusively on the volar side of the forearm of 10 volunteers, ranging in age from 20 to 25 years. Skin water content was measured daily and the results showed that skin humidity was increased significantly (p<0.05) for the formulation containing 20% egg phospholipids during 6 days. Liposome formulations prepared with egg phospholipids showed significantly higher (p<0.01) hydration effects during 3.5 h of application on human skin compared with liposome formulations prepared with soya phospholipids.

Authors+Show Affiliations

Institute of Pharmaceutical Technology, Pharmacenter, University of Basel, Klingelbergstr. 50, 4056 Basel, Switzerland.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

15885454

Citation

Betz, Gabriele, et al. "In Vivo Comparison of Various Liposome Formulations for Cosmetic Application." International Journal of Pharmaceutics, vol. 296, no. 1-2, 2005, pp. 44-54.
Betz G, Aeppli A, Menshutina N, et al. In vivo comparison of various liposome formulations for cosmetic application. Int J Pharm. 2005;296(1-2):44-54.
Betz, G., Aeppli, A., Menshutina, N., & Leuenberger, H. (2005). In vivo comparison of various liposome formulations for cosmetic application. International Journal of Pharmaceutics, 296(1-2), 44-54.
Betz G, et al. In Vivo Comparison of Various Liposome Formulations for Cosmetic Application. Int J Pharm. 2005 May 30;296(1-2):44-54. PubMed PMID: 15885454.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - In vivo comparison of various liposome formulations for cosmetic application. AU - Betz,Gabriele, AU - Aeppli,Angela, AU - Menshutina,Natalia, AU - Leuenberger,Hans, Y1 - 2005/04/08/ PY - 2004/06/18/received PY - 2005/02/11/revised PY - 2005/02/12/accepted PY - 2005/5/12/pubmed PY - 2005/12/31/medline PY - 2005/5/12/entrez SP - 44 EP - 54 JF - International journal of pharmaceutics JO - Int J Pharm VL - 296 IS - 1-2 N2 - The interaction of liposome formulations, prepared with phospholipids of different origins (egg and soya), with skin were compared in terms of their effects on skin water content, skin barrier function, and skin elasticity. Short-term effect of four different liposome formulations and two references during 3.5 h was investigated non-occlusively on the volar side of the forearm of 10 volunteers, ranging in age from 24 to 32 years. Liposomes composed of different phospholipids showed differing effects on skin humidity. The maximal effect was achieved within 30 min and constant values were reached after 1.5 h for all formulations, however values remained significantly higher than without treatment (p<0.05) during the whole application time. The best results were obtained with liposome formulations prepared from egg phospholipids, which exhibited a 1.5-fold increase in skin water content (p<0.05), whereas liposome formulations prepared from soya phospholipids showed no advantage compared to the references. Skin barrier function showed greatest influence within 30 min after application and remained constant after 1.5 h for all formulations. Within the liposome formulations, egg phospholipids showed the highest transepidermal water loss values during the first 30 min, representing the strongest interactions with the skin barrier function, whereas for the other liposome formulations lower transepidermal water loss values were measured. Skin elasticity and tiring effect of the skin was not influenced by any of the formulations, due to the young skin tested. Long-term effect of two different liposome formulations mixed with base cream DAC in two different concentrations during 14 days was investigated non-occlusively on the volar side of the forearm of 10 volunteers, ranging in age from 20 to 25 years. Skin water content was measured daily and the results showed that skin humidity was increased significantly (p<0.05) for the formulation containing 20% egg phospholipids during 6 days. Liposome formulations prepared with egg phospholipids showed significantly higher (p<0.01) hydration effects during 3.5 h of application on human skin compared with liposome formulations prepared with soya phospholipids. SN - 0378-5173 UR - https://www.unboundmedicine.com/medline/citation/15885454/In_vivo_comparison_of_various_liposome_formulations_for_cosmetic_application_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-5173(05)00147-X DB - PRIME DP - Unbound Medicine ER -