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Pathogenesis of levodopa-induced dyskinesia: focus on D1 and D3 dopamine receptors.
Parkinsonism Relat Disord. 2005 Jun; 11 Suppl 1:S25-9.PR

Abstract

Involuntary movements, or dyskinesia, represent a debilitating complication of levodopa therapy for Parkinson's disease. Taking advantage of a monkey brain bank constituted to study the pathophysiology of levodopa-induced dyskinesia, we here report the changes affecting D1, D2 and D3 dopamine receptors within the striatum of four experimental groups of non-human primates: normal, parkinsonian, parkinsonian treated with levodopa without or with dyskinesia. We also report the possible role of arrestin and G protein-coupled receptor kinases.

Authors+Show Affiliations

Basal Gang, Laboratoire de Physiologie et Physiopathologie de la Signalisation Cellulaire, CNRS UMR 5543, Université Victor Segalen-Bordeaux 2, France.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

15885624

Citation

Guigoni, C, et al. "Pathogenesis of Levodopa-induced Dyskinesia: Focus On D1 and D3 Dopamine Receptors." Parkinsonism & Related Disorders, vol. 11 Suppl 1, 2005, pp. S25-9.
Guigoni C, Aubert I, Li Q, et al. Pathogenesis of levodopa-induced dyskinesia: focus on D1 and D3 dopamine receptors. Parkinsonism Relat Disord. 2005;11 Suppl 1:S25-9.
Guigoni, C., Aubert, I., Li, Q., Gurevich, V. V., Benovic, J. L., Ferry, S., Mach, U., Stark, H., Leriche, L., Håkansson, K., Bioulac, B. H., Gross, C. E., Sokoloff, P., Fisone, G., Gurevich, E. V., Bloch, B., & Bezard, E. (2005). Pathogenesis of levodopa-induced dyskinesia: focus on D1 and D3 dopamine receptors. Parkinsonism & Related Disorders, 11 Suppl 1, S25-9.
Guigoni C, et al. Pathogenesis of Levodopa-induced Dyskinesia: Focus On D1 and D3 Dopamine Receptors. Parkinsonism Relat Disord. 2005;11 Suppl 1:S25-9. PubMed PMID: 15885624.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pathogenesis of levodopa-induced dyskinesia: focus on D1 and D3 dopamine receptors. AU - Guigoni,C, AU - Aubert,I, AU - Li,Q, AU - Gurevich,V V, AU - Benovic,J L, AU - Ferry,S, AU - Mach,U, AU - Stark,H, AU - Leriche,L, AU - Håkansson,K, AU - Bioulac,Bernard H, AU - Gross,Christian E, AU - Sokoloff,Pierre, AU - Fisone,Gilberto, AU - Gurevich,E V, AU - Bloch,Bertrand, AU - Bezard,Erwan, PY - 2004/10/14/received PY - 2004/11/20/revised PY - 2004/11/20/accepted PY - 2005/5/12/pubmed PY - 2005/7/26/medline PY - 2005/5/12/entrez SP - S25 EP - 9 JF - Parkinsonism & related disorders JO - Parkinsonism Relat Disord VL - 11 Suppl 1 N2 - Involuntary movements, or dyskinesia, represent a debilitating complication of levodopa therapy for Parkinson's disease. Taking advantage of a monkey brain bank constituted to study the pathophysiology of levodopa-induced dyskinesia, we here report the changes affecting D1, D2 and D3 dopamine receptors within the striatum of four experimental groups of non-human primates: normal, parkinsonian, parkinsonian treated with levodopa without or with dyskinesia. We also report the possible role of arrestin and G protein-coupled receptor kinases. SN - 1353-8020 UR - https://www.unboundmedicine.com/medline/citation/15885624/Pathogenesis_of_levodopa_induced_dyskinesia:_focus_on_D1_and_D3_dopamine_receptors_ DB - PRIME DP - Unbound Medicine ER -