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Controversy: is Parkinson's disease a single disease entity? Yes.
Parkinsonism Relat Disord. 2005 Jun; 11 Suppl 1:S31-7.PR

Abstract

Parkinson's disease (PD) is a common, and in principle, sporadic, neurodegenerative disorder that occurs in adults. Pathological studies have revealed that in PD, nerve cell loss and Lewy bodies (LB) are distributed widely in the nervous system. Moreover, molecular pathology has made remarkable advances over the last several years, after the identification of alpha-synuclein gene abnormality in familial PD. Extensive pathological findings support the idea that PD is a single disease entity and that there are no cases of PD in which neurodegeneration occurs only in the substantia nigra and in which there are no LBs.

Authors+Show Affiliations

Department of Pathology, Brain Research Institute, University of Niigata, Japan. hitoshi@bri.niigata-u.ac.jpNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

15885626

Citation

Takahashi, H, and K Wakabayashi. "Controversy: Is Parkinson's Disease a Single Disease Entity? Yes." Parkinsonism & Related Disorders, vol. 11 Suppl 1, 2005, pp. S31-7.
Takahashi H, Wakabayashi K. Controversy: is Parkinson's disease a single disease entity? Yes. Parkinsonism Relat Disord. 2005;11 Suppl 1:S31-7.
Takahashi, H., & Wakabayashi, K. (2005). Controversy: is Parkinson's disease a single disease entity? Yes. Parkinsonism & Related Disorders, 11 Suppl 1, S31-7.
Takahashi H, Wakabayashi K. Controversy: Is Parkinson's Disease a Single Disease Entity? Yes. Parkinsonism Relat Disord. 2005;11 Suppl 1:S31-7. PubMed PMID: 15885626.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Controversy: is Parkinson's disease a single disease entity? Yes. AU - Takahashi,H, AU - Wakabayashi,K, Y1 - 2005/04/20/ PY - 2005/01/01/received PY - 2005/02/02/accepted PY - 2005/5/12/pubmed PY - 2005/7/26/medline PY - 2005/5/12/entrez SP - S31 EP - 7 JF - Parkinsonism & related disorders JO - Parkinsonism Relat Disord VL - 11 Suppl 1 N2 - Parkinson's disease (PD) is a common, and in principle, sporadic, neurodegenerative disorder that occurs in adults. Pathological studies have revealed that in PD, nerve cell loss and Lewy bodies (LB) are distributed widely in the nervous system. Moreover, molecular pathology has made remarkable advances over the last several years, after the identification of alpha-synuclein gene abnormality in familial PD. Extensive pathological findings support the idea that PD is a single disease entity and that there are no cases of PD in which neurodegeneration occurs only in the substantia nigra and in which there are no LBs. SN - 1353-8020 UR - https://www.unboundmedicine.com/medline/citation/15885626/Controversy:_is_Parkinson's_disease_a_single_disease_entity_Yes_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1353-8020(05)00039-8 DB - PRIME DP - Unbound Medicine ER -