Abstract
The relationship of dementia with Lewy bodies (DLB) and Parkinson's disease with dementia (PDD) is debated. In DLB, dementia antedates Parkinsonism; in PDD, Parkinsonism antedates dementia. Other than presenting features, diagnostic measures fail to distinguish DLB from PDD. There are few or no pathologic differences between DLB and PDD. In most cases cortical Lewy bodies (LBs) are widespread and there is coexistent Alzheimer type pathology, insufficient to diagnose Alzheimer's disease. Given the predominance of Parkinsonism in PDD, neuronal loss in the substantia nigra is more severe in PDD than DLB. Further clinicopathologic studies are needed to define other pathologic differences between DLB and PDD and to explore the role of neuritic, basal forebrain and striatal pathology in these clinical syndromes.
TY - JOUR
T1 - Dementia with Lewy bodies and Parkinson's disease with dementia: are they different?
AU - Tsuboi,Yoshio,
AU - Dickson,Dennis W,
PY - 2004/09/29/received
PY - 2004/10/01/accepted
PY - 2005/5/12/pubmed
PY - 2005/7/26/medline
PY - 2005/5/12/entrez
SP - S47
EP - 51
JF - Parkinsonism & related disorders
JO - Parkinsonism Relat Disord
VL - 11 Suppl 1
N2 - The relationship of dementia with Lewy bodies (DLB) and Parkinson's disease with dementia (PDD) is debated. In DLB, dementia antedates Parkinsonism; in PDD, Parkinsonism antedates dementia. Other than presenting features, diagnostic measures fail to distinguish DLB from PDD. There are few or no pathologic differences between DLB and PDD. In most cases cortical Lewy bodies (LBs) are widespread and there is coexistent Alzheimer type pathology, insufficient to diagnose Alzheimer's disease. Given the predominance of Parkinsonism in PDD, neuronal loss in the substantia nigra is more severe in PDD than DLB. Further clinicopathologic studies are needed to define other pathologic differences between DLB and PDD and to explore the role of neuritic, basal forebrain and striatal pathology in these clinical syndromes.
SN - 1353-8020
UR - https://www.unboundmedicine.com/medline/citation/15885629/Dementia_with_Lewy_bodies_and_Parkinson's_disease_with_dementia:_are_they_different
L2 - https://linkinghub.elsevier.com/retrieve/pii/S1353-8020(05)00042-8
DB - PRIME
DP - Unbound Medicine
ER -