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Dementia with Lewy bodies and Parkinson's disease with dementia: are they different?
Parkinsonism Relat Disord. 2005 Jun; 11 Suppl 1:S47-51.PR

Abstract

The relationship of dementia with Lewy bodies (DLB) and Parkinson's disease with dementia (PDD) is debated. In DLB, dementia antedates Parkinsonism; in PDD, Parkinsonism antedates dementia. Other than presenting features, diagnostic measures fail to distinguish DLB from PDD. There are few or no pathologic differences between DLB and PDD. In most cases cortical Lewy bodies (LBs) are widespread and there is coexistent Alzheimer type pathology, insufficient to diagnose Alzheimer's disease. Given the predominance of Parkinsonism in PDD, neuronal loss in the substantia nigra is more severe in PDD than DLB. Further clinicopathologic studies are needed to define other pathologic differences between DLB and PDD and to explore the role of neuritic, basal forebrain and striatal pathology in these clinical syndromes.

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Publisher Full Text

Authors+Show Affiliations

Tsuboi Y
Fifth Department of Internal Medicine, Fukuoka University, Japan.
Dickson DW
No affiliation info available

MeSH

DementiaHumansLewy BodiesLewy Body DiseaseNeurofibrillary TanglesParkinson DiseasePlaque, AmyloidRetrospective StudiesSubstantia Nigra

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

15885629

Citation

Tsuboi, Yoshio, and Dennis W. Dickson. "Dementia With Lewy Bodies and Parkinson's Disease With Dementia: Are They Different?" Parkinsonism & Related Disorders, vol. 11 Suppl 1, 2005, pp. S47-51.
Tsuboi Y, Dickson DW. Dementia with Lewy bodies and Parkinson's disease with dementia: are they different? Parkinsonism Relat Disord. 2005;11 Suppl 1:S47-51.
Tsuboi, Y., & Dickson, D. W. (2005). Dementia with Lewy bodies and Parkinson's disease with dementia: are they different? Parkinsonism & Related Disorders, 11 Suppl 1, S47-51.
Tsuboi Y, Dickson DW. Dementia With Lewy Bodies and Parkinson's Disease With Dementia: Are They Different. Parkinsonism Relat Disord. 2005;11 Suppl 1:S47-51. PubMed PMID: 15885629.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dementia with Lewy bodies and Parkinson's disease with dementia: are they different? AU - Tsuboi,Yoshio, AU - Dickson,Dennis W, PY - 2004/09/29/received PY - 2004/10/01/accepted PY - 2005/5/12/pubmed PY - 2005/7/26/medline PY - 2005/5/12/entrez SP - S47 EP - 51 JF - Parkinsonism & related disorders JO - Parkinsonism Relat Disord VL - 11 Suppl 1 N2 - The relationship of dementia with Lewy bodies (DLB) and Parkinson's disease with dementia (PDD) is debated. In DLB, dementia antedates Parkinsonism; in PDD, Parkinsonism antedates dementia. Other than presenting features, diagnostic measures fail to distinguish DLB from PDD. There are few or no pathologic differences between DLB and PDD. In most cases cortical Lewy bodies (LBs) are widespread and there is coexistent Alzheimer type pathology, insufficient to diagnose Alzheimer's disease. Given the predominance of Parkinsonism in PDD, neuronal loss in the substantia nigra is more severe in PDD than DLB. Further clinicopathologic studies are needed to define other pathologic differences between DLB and PDD and to explore the role of neuritic, basal forebrain and striatal pathology in these clinical syndromes. SN - 1353-8020 UR - https://www.unboundmedicine.com/medline/citation/15885629/Dementia_with_Lewy_bodies_and_Parkinson's_disease_with_dementia:_are_they_different L2 - https://linkinghub.elsevier.com/retrieve/pii/S1353-8020(05)00042-8 DB - PRIME DP - Unbound Medicine ER -