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Neuroinflammatory processes in Parkinson's disease.
Parkinsonism Relat Disord. 2005 Jun; 11 Suppl 1:S9-S15.PR

Abstract

In Parkinson's disease (PD), post-mortem examination reveals a loss of dopaminergic (DA) neurons in the substantia nigra (SN) associated with a massive astrogliosis and the presence of activated microglial cells. Similarly, microglial activation has also been reported to be associated with the loss of DA neurons in animal models of PD induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), rotenone, annonacine and lipopolysaccharide (LPS). Recent evidence suggests that the disease may progress even when the initial cause of neuronal degeneration has disappeared, raising the possibility that toxic substances released by glial cells could be involved in the propagation of neuronal degeneration. Inhibition of the glial reaction and the inflammatory processes may thus represent a therapeutic target to reduce neuronal degeneration in PD.

Authors+Show Affiliations

INSERM U675, Experimental Neurology and Therapeutics, Hôpital de la Salpêtrière, Paris, France. hirsch@ccr.jussieu.frNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

15885630

Citation

Hirsch, Etienne C., et al. "Neuroinflammatory Processes in Parkinson's Disease." Parkinsonism & Related Disorders, vol. 11 Suppl 1, 2005, pp. S9-S15.
Hirsch EC, Hunot S, Hartmann A. Neuroinflammatory processes in Parkinson's disease. Parkinsonism Relat Disord. 2005;11 Suppl 1:S9-S15.
Hirsch, E. C., Hunot, S., & Hartmann, A. (2005). Neuroinflammatory processes in Parkinson's disease. Parkinsonism & Related Disorders, 11 Suppl 1, S9-S15.
Hirsch EC, Hunot S, Hartmann A. Neuroinflammatory Processes in Parkinson's Disease. Parkinsonism Relat Disord. 2005;11 Suppl 1:S9-S15. PubMed PMID: 15885630.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Neuroinflammatory processes in Parkinson's disease. AU - Hirsch,Etienne C, AU - Hunot,Stéphane, AU - Hartmann,Andreas, PY - 2004/09/29/received PY - 2004/10/01/accepted PY - 2005/5/12/pubmed PY - 2005/7/26/medline PY - 2005/5/12/entrez SP - S9 EP - S15 JF - Parkinsonism & related disorders JO - Parkinsonism Relat Disord VL - 11 Suppl 1 N2 - In Parkinson's disease (PD), post-mortem examination reveals a loss of dopaminergic (DA) neurons in the substantia nigra (SN) associated with a massive astrogliosis and the presence of activated microglial cells. Similarly, microglial activation has also been reported to be associated with the loss of DA neurons in animal models of PD induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), rotenone, annonacine and lipopolysaccharide (LPS). Recent evidence suggests that the disease may progress even when the initial cause of neuronal degeneration has disappeared, raising the possibility that toxic substances released by glial cells could be involved in the propagation of neuronal degeneration. Inhibition of the glial reaction and the inflammatory processes may thus represent a therapeutic target to reduce neuronal degeneration in PD. SN - 1353-8020 UR - https://www.unboundmedicine.com/medline/citation/15885630/Neuroinflammatory_processes_in_Parkinson's_disease_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1353-8020(05)00036-2 DB - PRIME DP - Unbound Medicine ER -
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