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Chemomodulatory effect of Ficus racemosa extract against chemically induced renal carcinogenesis and oxidative damage response in Wistar rats.
Life Sci. 2005 Jul 29; 77(11):1194-210.LS

Abstract

Ferric nitrilotriacetate (Fe-NTA) is a well-known renal carcinogen. In this communication, we show the chemopreventive effect of Ficus racemosa extract against Fe-NTA-induced renal oxidative stress, hyperproliferative response and renal carcinogenesis in rats. Fe-NTA (9 mg Fe/kg body weight, intraperitoneally) enhances renal lipid peroxidation, xanthine oxidase, gamma-glutamyl transpeptidase and hydrogen peroxide (H(2)O(2)) generation with reduction in renal glutathione content, antioxidant enzymes, viz., glutathione peroxidase, glutathione reductase, catalase, glucose-6-phosphate dehydrogenase and phase-II metabolising enzymes such as glutathione-S-transferase and quinone reductase. It also enhances blood urea nitrogen, serum creatinine, ornithine decarboxylase (ODC) activity and thymidine [(3)H] incorporation into renal DNA. It also enhances DEN (N-diethylnitrosamine) initiated renal carcinogenesis by increasing the percentage incidence of tumors. Treatment of rats orally with F. racemosa extract (200 and 400 mg/kg body weight) resulted in significant decrease in gamma-glutamyl transpeptidase, lipid peroxidation, xanthine oxidase, H(2)O(2) generation, blood urea nitrogen, serum creatinine, renal ODC activity, DNA synthesis (P<0.001) and incidence of tumors. Renal glutathione content (P<0.01), glutathione metabolizing enzymes (P<0.001) and antioxidant enzymes were also recovered to significant level (P<0.001). Thus, our data suggests that F. racemosa extract is a potent chemopreventive agent and suppresses Fe-NTA-induced renal carcinogenesis and oxidative damage response in Wistar rats.

Authors+Show Affiliations

Section of Chemoprevention and Nutrition Toxicology, Department of Medical Elementology and Toxicology, Faculty of Science, Jamia Hamdard (Hamdard University), New Delhi 110 062, India.No affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15885707

Citation

Khan, Naghma, and Sarwat Sultana. "Chemomodulatory Effect of Ficus Racemosa Extract Against Chemically Induced Renal Carcinogenesis and Oxidative Damage Response in Wistar Rats." Life Sciences, vol. 77, no. 11, 2005, pp. 1194-210.
Khan N, Sultana S. Chemomodulatory effect of Ficus racemosa extract against chemically induced renal carcinogenesis and oxidative damage response in Wistar rats. Life Sci. 2005;77(11):1194-210.
Khan, N., & Sultana, S. (2005). Chemomodulatory effect of Ficus racemosa extract against chemically induced renal carcinogenesis and oxidative damage response in Wistar rats. Life Sciences, 77(11), 1194-210.
Khan N, Sultana S. Chemomodulatory Effect of Ficus Racemosa Extract Against Chemically Induced Renal Carcinogenesis and Oxidative Damage Response in Wistar Rats. Life Sci. 2005 Jul 29;77(11):1194-210. PubMed PMID: 15885707.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Chemomodulatory effect of Ficus racemosa extract against chemically induced renal carcinogenesis and oxidative damage response in Wistar rats. AU - Khan,Naghma, AU - Sultana,Sarwat, PY - 2004/05/10/received PY - 2004/12/07/accepted PY - 2005/5/12/pubmed PY - 2005/8/3/medline PY - 2005/5/12/entrez SP - 1194 EP - 210 JF - Life sciences JO - Life Sci VL - 77 IS - 11 N2 - Ferric nitrilotriacetate (Fe-NTA) is a well-known renal carcinogen. In this communication, we show the chemopreventive effect of Ficus racemosa extract against Fe-NTA-induced renal oxidative stress, hyperproliferative response and renal carcinogenesis in rats. Fe-NTA (9 mg Fe/kg body weight, intraperitoneally) enhances renal lipid peroxidation, xanthine oxidase, gamma-glutamyl transpeptidase and hydrogen peroxide (H(2)O(2)) generation with reduction in renal glutathione content, antioxidant enzymes, viz., glutathione peroxidase, glutathione reductase, catalase, glucose-6-phosphate dehydrogenase and phase-II metabolising enzymes such as glutathione-S-transferase and quinone reductase. It also enhances blood urea nitrogen, serum creatinine, ornithine decarboxylase (ODC) activity and thymidine [(3)H] incorporation into renal DNA. It also enhances DEN (N-diethylnitrosamine) initiated renal carcinogenesis by increasing the percentage incidence of tumors. Treatment of rats orally with F. racemosa extract (200 and 400 mg/kg body weight) resulted in significant decrease in gamma-glutamyl transpeptidase, lipid peroxidation, xanthine oxidase, H(2)O(2) generation, blood urea nitrogen, serum creatinine, renal ODC activity, DNA synthesis (P<0.001) and incidence of tumors. Renal glutathione content (P<0.01), glutathione metabolizing enzymes (P<0.001) and antioxidant enzymes were also recovered to significant level (P<0.001). Thus, our data suggests that F. racemosa extract is a potent chemopreventive agent and suppresses Fe-NTA-induced renal carcinogenesis and oxidative damage response in Wistar rats. SN - 0024-3205 UR - https://www.unboundmedicine.com/medline/citation/15885707/Chemomodulatory_effect_of_Ficus_racemosa_extract_against_chemically_induced_renal_carcinogenesis_and_oxidative_damage_response_in_Wistar_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0024-3205(05)00335-8 DB - PRIME DP - Unbound Medicine ER -