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Comparison of arteritis and nonarteritic anterior ischemic optic neuropathies with the Heidelberg Retina Tomograph.
Ophthalmology. 2005 Jun; 112(6):1104-12.O

Abstract

OBJECTIVE

Quantitative data are not available regarding the morphological appearance of optic nerve morphology after arteritic anterior ischemic optic neuropathy (AAION) and nonarteritic anterior ischemic optic neuropathy (NAION). The purpose of this study is to evaluate the appearance of the optic nerve head in patients after AAION and NAION with the Heidelberg Retina Tomograph (HRT).

DESIGN

Prospective comparative observational study.

PARTICIPANTS

Thirty-eight patients with either unilateral AAION (15) or NAION (23).

METHODS

Heidelberg Retina Tomograph images were taken of both affected and unaffected eyes. The quantitative changes in the optic nerve head were morphologically evaluated and compared with those of the normal contralateral eyes.

MAIN OUTCOME MEASURES

Heidelberg Retina Tomograph parameters were analyzed using the uninvolved contralateral eye as a control.

RESULTS

The ratio between cup area and disc area was 42% larger in the affected eyes in the NAION group than in the fellow eyes (P = 0.03, t test). In the AAION patients, the ratio between cup area and disc area was 116% larger in involved eyes than in their fellow eyes (P = 0.0003, t test). In addition, in the AAION group, relative to their fellow eyes, the rim area was 27% smaller (P = 0.0006), cup volume was 160% larger (P = 0.021, t test), mean cup depth was 29% larger, cup shape measure differed by 41% (suggesting more excavation), and mean retinal nerve fiber layer thickness was 30% less. Relative to the fellow eyes in the NAION group, the rim area was 6% smaller (P = 0.13, Student's t test), and the cup shape measure was 13% different, although these were not statistically significant. When the uninvolved eyes of the NAION and AAION groups were compared directly, there was no statistical difference between any of the HRT parameters, except mean cup depth (0.09 vs. 0.14 mm, respectively; P = 0.02).

CONCLUSIONS

This study is the first to demonstrate quantitatively an enlargement and excavation of the optic cup after an event of AAION, but not NAION. The eyes affected with AAION showed significant excavation and enlargement of the optic cup when compared with contralateral uninvolved eyes. All HRT-generated parameters showed changes consistent with increased enlargement and excavation of AAION-involved eyes. These changes were not observed in eyes that experienced an event of NAION.

Authors+Show Affiliations

Department of Ophthalmology, University of Auckland, Auckland, New Zealand.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

15885786

Citation

Danesh-Meyer, Helen, et al. "Comparison of Arteritis and Nonarteritic Anterior Ischemic Optic Neuropathies With the Heidelberg Retina Tomograph." Ophthalmology, vol. 112, no. 6, 2005, pp. 1104-12.
Danesh-Meyer H, Savino PJ, Spaeth GL, et al. Comparison of arteritis and nonarteritic anterior ischemic optic neuropathies with the Heidelberg Retina Tomograph. Ophthalmology. 2005;112(6):1104-12.
Danesh-Meyer, H., Savino, P. J., Spaeth, G. L., & Gamble, G. D. (2005). Comparison of arteritis and nonarteritic anterior ischemic optic neuropathies with the Heidelberg Retina Tomograph. Ophthalmology, 112(6), 1104-12.
Danesh-Meyer H, et al. Comparison of Arteritis and Nonarteritic Anterior Ischemic Optic Neuropathies With the Heidelberg Retina Tomograph. Ophthalmology. 2005;112(6):1104-12. PubMed PMID: 15885786.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparison of arteritis and nonarteritic anterior ischemic optic neuropathies with the Heidelberg Retina Tomograph. AU - Danesh-Meyer,Helen, AU - Savino,Peter J, AU - Spaeth,George L, AU - Gamble,Greg D, PY - 2004/11/04/received PY - 2004/12/21/accepted PY - 2005/5/12/pubmed PY - 2005/6/15/medline PY - 2005/5/12/entrez SP - 1104 EP - 12 JF - Ophthalmology JO - Ophthalmology VL - 112 IS - 6 N2 - OBJECTIVE: Quantitative data are not available regarding the morphological appearance of optic nerve morphology after arteritic anterior ischemic optic neuropathy (AAION) and nonarteritic anterior ischemic optic neuropathy (NAION). The purpose of this study is to evaluate the appearance of the optic nerve head in patients after AAION and NAION with the Heidelberg Retina Tomograph (HRT). DESIGN: Prospective comparative observational study. PARTICIPANTS: Thirty-eight patients with either unilateral AAION (15) or NAION (23). METHODS: Heidelberg Retina Tomograph images were taken of both affected and unaffected eyes. The quantitative changes in the optic nerve head were morphologically evaluated and compared with those of the normal contralateral eyes. MAIN OUTCOME MEASURES: Heidelberg Retina Tomograph parameters were analyzed using the uninvolved contralateral eye as a control. RESULTS: The ratio between cup area and disc area was 42% larger in the affected eyes in the NAION group than in the fellow eyes (P = 0.03, t test). In the AAION patients, the ratio between cup area and disc area was 116% larger in involved eyes than in their fellow eyes (P = 0.0003, t test). In addition, in the AAION group, relative to their fellow eyes, the rim area was 27% smaller (P = 0.0006), cup volume was 160% larger (P = 0.021, t test), mean cup depth was 29% larger, cup shape measure differed by 41% (suggesting more excavation), and mean retinal nerve fiber layer thickness was 30% less. Relative to the fellow eyes in the NAION group, the rim area was 6% smaller (P = 0.13, Student's t test), and the cup shape measure was 13% different, although these were not statistically significant. When the uninvolved eyes of the NAION and AAION groups were compared directly, there was no statistical difference between any of the HRT parameters, except mean cup depth (0.09 vs. 0.14 mm, respectively; P = 0.02). CONCLUSIONS: This study is the first to demonstrate quantitatively an enlargement and excavation of the optic cup after an event of AAION, but not NAION. The eyes affected with AAION showed significant excavation and enlargement of the optic cup when compared with contralateral uninvolved eyes. All HRT-generated parameters showed changes consistent with increased enlargement and excavation of AAION-involved eyes. These changes were not observed in eyes that experienced an event of NAION. SN - 1549-4713 UR - https://www.unboundmedicine.com/medline/citation/15885786/Comparison_of_arteritis_and_nonarteritic_anterior_ischemic_optic_neuropathies_with_the_Heidelberg_Retina_Tomograph_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0161-6420(05)00133-8 DB - PRIME DP - Unbound Medicine ER -