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Type-II diabetes and pancreatic cancer: a meta-analysis of 36 studies.

Abstract

Pancreatic cancer is the eighth major form of cancer-related death worldwide, causing 227 000 deaths annually. Type-II diabetes is widely considered to be associated with pancreatic cancer, but whether this represents a causal or consequential association is unclear. We conducted a meta-analysis to examine this association. A computer-based literature search from 1966 to 2005 yielded 17 case-control and 19 cohort or nested case-control studies with information on 9220 individuals with pancreatic cancer. The age and sex-adjusted odds ratio (OR) for pancreatic cancer associated with type-II diabetes was obtained from each study. The combined summary odds ratio was 1.82 (95% confidence interval (95% CI) 1.66-1.89), with evidence of heterogeneity across the studies (P=0.002 for case-control and P=0.05 for cohort studies) that was explained, in part, by higher risks being reported by smaller studies and studies that reported before 2000. Individuals in whom diabetes had only recently been diagnosed (< 4 years) had a 50% greater risk of the malignancy compared with individuals who had diabetes for > or =5 years (OR 2.1 vs 1.5; P=0.005). These results support a modest causal association between type-II diabetes and pancreatic cancer.

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  • Authors+Show Affiliations

    ,

    The George Institute for International Health, The University of Sydney, PO Box M201, Missenden Road, Sydney NSW 2050, Australia. rhuxley@thegeorgeinstitute.org

    , , ,

    Source

    British journal of cancer 92:11 2005 Jun 06 pg 2076-83

    MeSH

    Case-Control Studies
    Cohort Studies
    Diabetes Mellitus, Type 2
    Humans
    Odds Ratio
    Pancreatic Neoplasms
    Risk Factors
    Time Factors

    Pub Type(s)

    Journal Article
    Meta-Analysis

    Language

    eng

    PubMed ID

    15886696

    Citation

    Huxley, R, et al. "Type-II Diabetes and Pancreatic Cancer: a Meta-analysis of 36 Studies." British Journal of Cancer, vol. 92, no. 11, 2005, pp. 2076-83.
    Huxley R, Ansary-Moghaddam A, Berrington de González A, et al. Type-II diabetes and pancreatic cancer: a meta-analysis of 36 studies. Br J Cancer. 2005;92(11):2076-83.
    Huxley, R., Ansary-Moghaddam, A., Berrington de González, A., Barzi, F., & Woodward, M. (2005). Type-II diabetes and pancreatic cancer: a meta-analysis of 36 studies. British Journal of Cancer, 92(11), pp. 2076-83.
    Huxley R, et al. Type-II Diabetes and Pancreatic Cancer: a Meta-analysis of 36 Studies. Br J Cancer. 2005 Jun 6;92(11):2076-83. PubMed PMID: 15886696.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Type-II diabetes and pancreatic cancer: a meta-analysis of 36 studies. AU - Huxley,R, AU - Ansary-Moghaddam,A, AU - Berrington de González,A, AU - Barzi,F, AU - Woodward,M, PY - 2005/5/12/pubmed PY - 2005/7/22/medline PY - 2005/5/12/entrez SP - 2076 EP - 83 JF - British journal of cancer JO - Br. J. Cancer VL - 92 IS - 11 N2 - Pancreatic cancer is the eighth major form of cancer-related death worldwide, causing 227 000 deaths annually. Type-II diabetes is widely considered to be associated with pancreatic cancer, but whether this represents a causal or consequential association is unclear. We conducted a meta-analysis to examine this association. A computer-based literature search from 1966 to 2005 yielded 17 case-control and 19 cohort or nested case-control studies with information on 9220 individuals with pancreatic cancer. The age and sex-adjusted odds ratio (OR) for pancreatic cancer associated with type-II diabetes was obtained from each study. The combined summary odds ratio was 1.82 (95% confidence interval (95% CI) 1.66-1.89), with evidence of heterogeneity across the studies (P=0.002 for case-control and P=0.05 for cohort studies) that was explained, in part, by higher risks being reported by smaller studies and studies that reported before 2000. Individuals in whom diabetes had only recently been diagnosed (< 4 years) had a 50% greater risk of the malignancy compared with individuals who had diabetes for > or =5 years (OR 2.1 vs 1.5; P=0.005). These results support a modest causal association between type-II diabetes and pancreatic cancer. SN - 0007-0920 UR - https://www.unboundmedicine.com/medline/citation/15886696/full_citation L2 - http://dx.doi.org/10.1038/sj.bjc.6602619 DB - PRIME DP - Unbound Medicine ER -