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Precursor lesions in patients with multiple endocrine neoplasia type 1-associated duodenal gastrinomas.
Gastroenterology. 2005 May; 128(5):1187-98.G

Abstract

BACKGROUND & AIMS

The identification of precursor lesions has a great impact on the understanding of tumorigenesis. Precursor lesions of endocrine tumors are known to occur in the setting of the MEN1 syndrome. The aim of this study was to test the hypothesis that MEN1-associated duodenal gastrinomas originate from diffuse preneoplastic gastrin cell changes. Precursor lesions may precede the development of duodenal gastrinomas because, in contrast to sporadic gastrinomas, these tumors are usually multiple.

METHODS

The distribution of endocrine cells in the nontumorous duodenal tissue was analyzed qualitatively and quantitatively for 25 patients operated on for a duodenal gastrinoma. MEN1 status was assessed clinically and by polymerase chain reaction-based mutational analysis.

RESULTS

Fourteen of 25 patients with gastrinoma had proliferative, hyperplastic lesions consisting of gastrin cells in the nontumorous duodenal mucosa, similar to the gastric enterochromaffin-like cell lesions observed in chronic atrophic gastritis. All patients with Zollinger-Ellison syndrome with proven MEN1 had such proliferative gastrin cell lesions, and all patients with Zollinger-Ellison syndrome without precursor lesions were MEN1 negative.

CONCLUSIONS

Duodenal gastrinomas in MEN1, but not sporadic duodenal gastrinomas, are associated with proliferative gastrin cell changes within the nontumorous mucosa. It is likely that these lesions precede the development of MEN1-associated duodenal gastrinomas.

Authors+Show Affiliations

Department of Pathology, Univeristy of Kiel, Germany. manlauf@path.uni-kiel.deNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15887103

Citation

Anlauf, Martin, et al. "Precursor Lesions in Patients With Multiple Endocrine Neoplasia Type 1-associated Duodenal Gastrinomas." Gastroenterology, vol. 128, no. 5, 2005, pp. 1187-98.
Anlauf M, Perren A, Meyer CL, et al. Precursor lesions in patients with multiple endocrine neoplasia type 1-associated duodenal gastrinomas. Gastroenterology. 2005;128(5):1187-98.
Anlauf, M., Perren, A., Meyer, C. L., Schmid, S., Saremaslani, P., Kruse, M. L., Weihe, E., Komminoth, P., Heitz, P. U., & Klöppel, G. (2005). Precursor lesions in patients with multiple endocrine neoplasia type 1-associated duodenal gastrinomas. Gastroenterology, 128(5), 1187-98.
Anlauf M, et al. Precursor Lesions in Patients With Multiple Endocrine Neoplasia Type 1-associated Duodenal Gastrinomas. Gastroenterology. 2005;128(5):1187-98. PubMed PMID: 15887103.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Precursor lesions in patients with multiple endocrine neoplasia type 1-associated duodenal gastrinomas. AU - Anlauf,Martin, AU - Perren,Aurel, AU - Meyer,Cora Lu, AU - Schmid,Sonja, AU - Saremaslani,Parvin, AU - Kruse,Marie L, AU - Weihe,Eberhard, AU - Komminoth,Paul, AU - Heitz,Philipp U, AU - Klöppel,Günter, PY - 2005/5/12/pubmed PY - 2005/7/6/medline PY - 2005/5/12/entrez SP - 1187 EP - 98 JF - Gastroenterology JO - Gastroenterology VL - 128 IS - 5 N2 - BACKGROUND & AIMS: The identification of precursor lesions has a great impact on the understanding of tumorigenesis. Precursor lesions of endocrine tumors are known to occur in the setting of the MEN1 syndrome. The aim of this study was to test the hypothesis that MEN1-associated duodenal gastrinomas originate from diffuse preneoplastic gastrin cell changes. Precursor lesions may precede the development of duodenal gastrinomas because, in contrast to sporadic gastrinomas, these tumors are usually multiple. METHODS: The distribution of endocrine cells in the nontumorous duodenal tissue was analyzed qualitatively and quantitatively for 25 patients operated on for a duodenal gastrinoma. MEN1 status was assessed clinically and by polymerase chain reaction-based mutational analysis. RESULTS: Fourteen of 25 patients with gastrinoma had proliferative, hyperplastic lesions consisting of gastrin cells in the nontumorous duodenal mucosa, similar to the gastric enterochromaffin-like cell lesions observed in chronic atrophic gastritis. All patients with Zollinger-Ellison syndrome with proven MEN1 had such proliferative gastrin cell lesions, and all patients with Zollinger-Ellison syndrome without precursor lesions were MEN1 negative. CONCLUSIONS: Duodenal gastrinomas in MEN1, but not sporadic duodenal gastrinomas, are associated with proliferative gastrin cell changes within the nontumorous mucosa. It is likely that these lesions precede the development of MEN1-associated duodenal gastrinomas. SN - 0016-5085 UR - https://www.unboundmedicine.com/medline/citation/15887103/Precursor_lesions_in_patients_with_multiple_endocrine_neoplasia_type_1_associated_duodenal_gastrinomas_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0016508505003987 DB - PRIME DP - Unbound Medicine ER -