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[Clinico-pathology and differential diagnosis of Binswanger's disease].
Ideggyogy Sz. 2005 Mar 20; 58(3-4):78-87.IS

Abstract

Pathologically, Binswanger's disease is subcortical periventricular leucoencephalopathy sparing the U fibers. Clinically it is characterised by executive dysfunction, gait problems, urinary incontinence, pseudobulbar palsy, mood disturbances and dementia. The pathomechanism of Binswanger's disease is unclear. It is hypothesized that it results from an ischemic-hypoxic injury of the periventricular white matter, which, in turn, can be caused by a sclerotic elongation of the medullary arteries, widening of the perivascular spaces or decreased brain perfusion due to hypotension or heart disease. The symptoms of Binswanger's disease frequently overlap with those of normal pressure hydrocephalus, vascular parkinsonism and Alzheimer's disease. A diagnostic criterion of Binswanger's disease is radiologically demonstrated leukoaraiosis, which, on the other hand, is not equivalent with Binswanger's disease. A good clinical response after lumbar puncture or shunt implantation might lead to confusion with normal pressure hydrocephalus, which further complicates the clinical diagnosis. It is likely that among the above mentioned disorders there are a number of transitional forms and overlaps, which might be explained by the common pathomechanism of disturbance in cerebrospinal fluid circulation.

Authors+Show Affiliations

Semmelweis Egyetem, Altalános Orvostudományi Kar, Neurológiai Klinika, Budapest. tibor@neur.sote.huNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
English Abstract
Journal Article
Review

Language

hun

PubMed ID

15887411

Citation

Kovács, Tibor, et al. "[Clinico-pathology and Differential Diagnosis of Binswanger's Disease]." Ideggyogyaszati Szemle, vol. 58, no. 3-4, 2005, pp. 78-87.
Kovács T, Szirmai I, Papp M. [Clinico-pathology and differential diagnosis of Binswanger's disease]. Ideggyogy Sz. 2005;58(3-4):78-87.
Kovács, T., Szirmai, I., & Papp, M. (2005). [Clinico-pathology and differential diagnosis of Binswanger's disease]. Ideggyogyaszati Szemle, 58(3-4), 78-87.
Kovács T, Szirmai I, Papp M. [Clinico-pathology and Differential Diagnosis of Binswanger's Disease]. Ideggyogy Sz. 2005 Mar 20;58(3-4):78-87. PubMed PMID: 15887411.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Clinico-pathology and differential diagnosis of Binswanger's disease]. AU - Kovács,Tibor, AU - Szirmai,Imre, AU - Papp,Mátyás, PY - 2005/5/13/pubmed PY - 2005/6/1/medline PY - 2005/5/13/entrez SP - 78 EP - 87 JF - Ideggyogyaszati szemle JO - Ideggyogy Sz VL - 58 IS - 3-4 N2 - Pathologically, Binswanger's disease is subcortical periventricular leucoencephalopathy sparing the U fibers. Clinically it is characterised by executive dysfunction, gait problems, urinary incontinence, pseudobulbar palsy, mood disturbances and dementia. The pathomechanism of Binswanger's disease is unclear. It is hypothesized that it results from an ischemic-hypoxic injury of the periventricular white matter, which, in turn, can be caused by a sclerotic elongation of the medullary arteries, widening of the perivascular spaces or decreased brain perfusion due to hypotension or heart disease. The symptoms of Binswanger's disease frequently overlap with those of normal pressure hydrocephalus, vascular parkinsonism and Alzheimer's disease. A diagnostic criterion of Binswanger's disease is radiologically demonstrated leukoaraiosis, which, on the other hand, is not equivalent with Binswanger's disease. A good clinical response after lumbar puncture or shunt implantation might lead to confusion with normal pressure hydrocephalus, which further complicates the clinical diagnosis. It is likely that among the above mentioned disorders there are a number of transitional forms and overlaps, which might be explained by the common pathomechanism of disturbance in cerebrospinal fluid circulation. SN - 0019-1442 UR - https://www.unboundmedicine.com/medline/citation/15887411/[Clinico_pathology_and_differential_diagnosis_of_Binswanger's_disease]_ L2 - http://www.diseaseinfosearch.org/result/844 DB - PRIME DP - Unbound Medicine ER -