Tags

Type your tag names separated by a space and hit enter

Comparison of external dacryocystorhinostomy and 5-fluorouracil augmented endonasal laser dacryocystorhinostomy. A retrospective review.
Indian J Ophthalmol. 2001 Sep; 49(3):169-72.IJ

Abstract

PURPOSE

To compare the success rates of external dacryocystorhinostomy (EXT-DCR) with 5-fluorouracil (5-FU) augmented endonasal laser dacryocystorhinostomy (ENL-DCR) and to record the complications associated with 5-FU augmented ENL-DCR MATERIALS AND METHODS: This was a retrospective non-randomised study. Forty-one patients with primary acquired nasolacrimal duct obstruction underwent an EXT-DCR (19 patients) or an ENL-DCR (22 patients) over a 3-year period. A Holmium YAG laser (Ho:YAG) was used in the latter group of patients. Silicone tubes intubated in all patients were removed at three months. 5-FU was applied intraoperatively at the site of the ostium in the ENL-DCR patients. The median follow-up was 12 months (range 3-24 months) for the ENL-DCR group and 22 months (range 6-28 months) for the EXT-DCR group. The patency of the lacrimal system and the severity of epiphora were assessed at a final-review.

RESULTS

The median age of the EXT-DCR group was 77 years (range 53-87) and that of the ENL-DCR group was 71 years (range 23 to 84). There were 12 female patients in the former group and 19 in the latter. The percentage of success in the EXT-DCR group was 94.7% (95% confidence interval (CI) = 75.4-99.1) =), and 63.6% in the ENL-DCR group (95% CI= 43.0-80.3). The confidence interval for the difference of 31.1% was 5.6-52.2. There was a statistically significant difference between the two groups, p=0.024 (Fisher exact test).

CONCLUSIONS

These data suggest that EXT-DCR provides better results than 5-FU augmented ENL-DCR. However, ENL-DCR is the procedure of choice in certain circumstances such as in elderly, frail or medically unfit patients. Our results of 5-FU augmented ENL-DCR compare favourably with other published series.

Authors+Show Affiliations

Department of Ophthalmology, Royal Glamorgan Hospital, South Wales, United Kingdom. patrickowatts@hotmail.comNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

15887724

Citation

Watts, P, et al. "Comparison of External Dacryocystorhinostomy and 5-fluorouracil Augmented Endonasal Laser Dacryocystorhinostomy. a Retrospective Review." Indian Journal of Ophthalmology, vol. 49, no. 3, 2001, pp. 169-72.
Watts P, Ram AR, Nair R, et al. Comparison of external dacryocystorhinostomy and 5-fluorouracil augmented endonasal laser dacryocystorhinostomy. A retrospective review. Indian J Ophthalmol. 2001;49(3):169-72.
Watts, P., Ram, A. R., Nair, R., & Williams, H. (2001). Comparison of external dacryocystorhinostomy and 5-fluorouracil augmented endonasal laser dacryocystorhinostomy. A retrospective review. Indian Journal of Ophthalmology, 49(3), 169-72.
Watts P, et al. Comparison of External Dacryocystorhinostomy and 5-fluorouracil Augmented Endonasal Laser Dacryocystorhinostomy. a Retrospective Review. Indian J Ophthalmol. 2001;49(3):169-72. PubMed PMID: 15887724.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparison of external dacryocystorhinostomy and 5-fluorouracil augmented endonasal laser dacryocystorhinostomy. A retrospective review. AU - Watts,P, AU - Ram,A R, AU - Nair,R, AU - Williams,H, PY - 2005/5/13/pubmed PY - 2005/6/3/medline PY - 2005/5/13/entrez SP - 169 EP - 72 JF - Indian journal of ophthalmology JO - Indian J Ophthalmol VL - 49 IS - 3 N2 - PURPOSE: To compare the success rates of external dacryocystorhinostomy (EXT-DCR) with 5-fluorouracil (5-FU) augmented endonasal laser dacryocystorhinostomy (ENL-DCR) and to record the complications associated with 5-FU augmented ENL-DCR MATERIALS AND METHODS: This was a retrospective non-randomised study. Forty-one patients with primary acquired nasolacrimal duct obstruction underwent an EXT-DCR (19 patients) or an ENL-DCR (22 patients) over a 3-year period. A Holmium YAG laser (Ho:YAG) was used in the latter group of patients. Silicone tubes intubated in all patients were removed at three months. 5-FU was applied intraoperatively at the site of the ostium in the ENL-DCR patients. The median follow-up was 12 months (range 3-24 months) for the ENL-DCR group and 22 months (range 6-28 months) for the EXT-DCR group. The patency of the lacrimal system and the severity of epiphora were assessed at a final-review. RESULTS: The median age of the EXT-DCR group was 77 years (range 53-87) and that of the ENL-DCR group was 71 years (range 23 to 84). There were 12 female patients in the former group and 19 in the latter. The percentage of success in the EXT-DCR group was 94.7% (95% confidence interval (CI) = 75.4-99.1) =), and 63.6% in the ENL-DCR group (95% CI= 43.0-80.3). The confidence interval for the difference of 31.1% was 5.6-52.2. There was a statistically significant difference between the two groups, p=0.024 (Fisher exact test). CONCLUSIONS: These data suggest that EXT-DCR provides better results than 5-FU augmented ENL-DCR. However, ENL-DCR is the procedure of choice in certain circumstances such as in elderly, frail or medically unfit patients. Our results of 5-FU augmented ENL-DCR compare favourably with other published series. SN - 0301-4738 UR - https://www.unboundmedicine.com/medline/citation/15887724/Comparison_of_external_dacryocystorhinostomy_and_5_fluorouracil_augmented_endonasal_laser_dacryocystorhinostomy__A_retrospective_review_ L2 - http://www.ijo.in/article.asp?issn=0301-4738;year=2001;volume=49;issue=3;spage=169;epage=172;aulast=Watts DB - PRIME DP - Unbound Medicine ER -