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The p38 signal transduction pathway participates in the oxidative stress-mediated translocation of DAF-16 to Caenorhabditis elegans nuclei.
Mech Ageing Dev 2005 Jun-Jul; 126(6-7):642-7MA

Abstract

Much attention has focused on the insulin-like signaling pathway in Caenorhabditis elegans because of its pivotal role in life-span determination and oxidative stress resistance. The daf-16 gene encodes a fork-head transcription factor that is negatively regulated by this insulin-signaling pathway. The DAF-16 protein is translocated to the nucleus when animals were subjected to oxidative stress in the form of paraquat. This oxidative stress-mediated translocation was blocked by mutation of the p38-related sek-1 (MAPKK) mutant and DAF-16 instead remained cytoplasmic. The fact that DAF-16 translocation by oxidative stress is epistatic to sek-1 suggests that oxidative stress mediates regulation of DAF-16 through activating the p38 signal transduction pathway upstream of daf-16 so as to mobilize DAF-16 to the nucleus and activate transcription.

Authors+Show Affiliations

Department of Molecular Life Science, Tokai University School of Medicine, Isehara, Kanagawa, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15888317

Citation

Kondo, Masaki, et al. "The P38 Signal Transduction Pathway Participates in the Oxidative Stress-mediated Translocation of DAF-16 to Caenorhabditis Elegans Nuclei." Mechanisms of Ageing and Development, vol. 126, no. 6-7, 2005, pp. 642-7.
Kondo M, Yanase S, Ishii T, et al. The p38 signal transduction pathway participates in the oxidative stress-mediated translocation of DAF-16 to Caenorhabditis elegans nuclei. Mech Ageing Dev. 2005;126(6-7):642-7.
Kondo, M., Yanase, S., Ishii, T., Hartman, P. S., Matsumoto, K., & Ishii, N. (2005). The p38 signal transduction pathway participates in the oxidative stress-mediated translocation of DAF-16 to Caenorhabditis elegans nuclei. Mechanisms of Ageing and Development, 126(6-7), pp. 642-7.
Kondo M, et al. The P38 Signal Transduction Pathway Participates in the Oxidative Stress-mediated Translocation of DAF-16 to Caenorhabditis Elegans Nuclei. Mech Ageing Dev. 2005;126(6-7):642-7. PubMed PMID: 15888317.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The p38 signal transduction pathway participates in the oxidative stress-mediated translocation of DAF-16 to Caenorhabditis elegans nuclei. AU - Kondo,Masaki, AU - Yanase,Sumino, AU - Ishii,Takamasa, AU - Hartman,Philip S, AU - Matsumoto,Kunihiro, AU - Ishii,Naoaki, Y1 - 2005/01/11/ PY - 2004/11/11/accepted PY - 2005/5/13/pubmed PY - 2005/9/2/medline PY - 2005/5/13/entrez SP - 642 EP - 7 JF - Mechanisms of ageing and development JO - Mech. Ageing Dev. VL - 126 IS - 6-7 N2 - Much attention has focused on the insulin-like signaling pathway in Caenorhabditis elegans because of its pivotal role in life-span determination and oxidative stress resistance. The daf-16 gene encodes a fork-head transcription factor that is negatively regulated by this insulin-signaling pathway. The DAF-16 protein is translocated to the nucleus when animals were subjected to oxidative stress in the form of paraquat. This oxidative stress-mediated translocation was blocked by mutation of the p38-related sek-1 (MAPKK) mutant and DAF-16 instead remained cytoplasmic. The fact that DAF-16 translocation by oxidative stress is epistatic to sek-1 suggests that oxidative stress mediates regulation of DAF-16 through activating the p38 signal transduction pathway upstream of daf-16 so as to mobilize DAF-16 to the nucleus and activate transcription. SN - 0047-6374 UR - https://www.unboundmedicine.com/medline/citation/15888317/The_p38_signal_transduction_pathway_participates_in_the_oxidative_stress_mediated_translocation_of_DAF_16_to_Caenorhabditis_elegans_nuclei_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0047-6374(04)00305-7 DB - PRIME DP - Unbound Medicine ER -