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The effects of high-dose and low-dose tryptophan depletion on mood and cognitive functions of remitted depressed patients.
J Psychopharmacol 2005; 19(3):267-75JP

Abstract

It has frequently been demonstrated that acute tryptophan depletion (ATD) induces a transient depressed mood in some patients who are in remission from depression. However, the effects of ATD on cognitive processes in remitted depressed patients have not been investigated. The aim of the present study was to investigate the effects of different extents of depletion on mood and cognitive tasks involving neutral and emotional stimuli. Twenty patients in remission or in partial remission from depression received ATD in a double-blind, crossover design. Mood was assessed at both sessions before, at +6.5 h and +24 h after depletion. Cognitive assessment in both sessions started at +4.75 h, and also before and after the whole procedure. The ATD mixtures induced the expected reductions of plasma tryptophan levels. High-dose ATD induced a depressive response in a subsample of patients and impaired the processing of positive information independent of mood change. Attention for neutral stimuli (Stroop interference) improved in a dose-dependent manner. ATD may affect mood and cognition via different pathways: one implicated in mood regulation and the processing of emotional information, and one for the processing of neutral information. The first pathway may be more important for discriminating vulnerability to impaired serotonin function. The comparison of the effects of high-dose and low-dose ATD is useful for those studies aiming to investigate the relationships among 5-HT, mood and cognition.

Authors+Show Affiliations

Department of Psychology, Leiden University, Leiden, The Netherlands and Psychomedical Center Parnassia, The Hague, The Netherlands.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15888512

Citation

Booij, Linda, et al. "The Effects of High-dose and Low-dose Tryptophan Depletion On Mood and Cognitive Functions of Remitted Depressed Patients." Journal of Psychopharmacology (Oxford, England), vol. 19, no. 3, 2005, pp. 267-75.
Booij L, Van der Does AJ, Haffmans PM, et al. The effects of high-dose and low-dose tryptophan depletion on mood and cognitive functions of remitted depressed patients. J Psychopharmacol (Oxford). 2005;19(3):267-75.
Booij, L., Van der Does, A. J., Haffmans, P. M., Riedel, W. J., Fekkes, D., & Blom, M. J. (2005). The effects of high-dose and low-dose tryptophan depletion on mood and cognitive functions of remitted depressed patients. Journal of Psychopharmacology (Oxford, England), 19(3), pp. 267-75.
Booij L, et al. The Effects of High-dose and Low-dose Tryptophan Depletion On Mood and Cognitive Functions of Remitted Depressed Patients. J Psychopharmacol (Oxford). 2005;19(3):267-75. PubMed PMID: 15888512.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effects of high-dose and low-dose tryptophan depletion on mood and cognitive functions of remitted depressed patients. AU - Booij,Linda, AU - Van der Does,A J Willem, AU - Haffmans,P M Judith, AU - Riedel,Wim J, AU - Fekkes,Durk, AU - Blom,Marc J B, PY - 2005/5/13/pubmed PY - 2005/6/28/medline PY - 2005/5/13/entrez SP - 267 EP - 75 JF - Journal of psychopharmacology (Oxford, England) JO - J. Psychopharmacol. (Oxford) VL - 19 IS - 3 N2 - It has frequently been demonstrated that acute tryptophan depletion (ATD) induces a transient depressed mood in some patients who are in remission from depression. However, the effects of ATD on cognitive processes in remitted depressed patients have not been investigated. The aim of the present study was to investigate the effects of different extents of depletion on mood and cognitive tasks involving neutral and emotional stimuli. Twenty patients in remission or in partial remission from depression received ATD in a double-blind, crossover design. Mood was assessed at both sessions before, at +6.5 h and +24 h after depletion. Cognitive assessment in both sessions started at +4.75 h, and also before and after the whole procedure. The ATD mixtures induced the expected reductions of plasma tryptophan levels. High-dose ATD induced a depressive response in a subsample of patients and impaired the processing of positive information independent of mood change. Attention for neutral stimuli (Stroop interference) improved in a dose-dependent manner. ATD may affect mood and cognition via different pathways: one implicated in mood regulation and the processing of emotional information, and one for the processing of neutral information. The first pathway may be more important for discriminating vulnerability to impaired serotonin function. The comparison of the effects of high-dose and low-dose ATD is useful for those studies aiming to investigate the relationships among 5-HT, mood and cognition. SN - 0269-8811 UR - https://www.unboundmedicine.com/medline/citation/15888512/The_effects_of_high_dose_and_low_dose_tryptophan_depletion_on_mood_and_cognitive_functions_of_remitted_depressed_patients_ L2 - http://journals.sagepub.com/doi/full/10.1177/0269881105051538?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -