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Breast augmentation: a risk factor for breast cancer?
N Engl J Med. 1992 Jun 18; 326(25):1649-53.NEJM

Abstract

BACKGROUND

A relation between breast augmentation and the subsequent risk of breast cancer has been postulated. Since an estimated 2 million women in the United States alone have received breast implants, even a small increase in the risk of breast cancer could have considerable public health consequences.

METHODS

We performed a population-based nonconcurrent cohort-linkage study. All women in Alberta, Canada, who underwent cosmetic breast augmentation from 1973 through 1986 were included in the implant cohort (n = 11,676). This cohort was compared with the cohort of all women in Alberta in whom a first primary breast cancer was diagnosed (n = 13,557). The expected number of breast-cancer cases in the implant cohort was estimated by applying age-specific and calendar year--specific incidence rates of breast cancer (obtained from the Alberta Cancer Registry) to the implant cohort. Standardized incidence ratios were calculated by dividing the observed by the expected number of breast-cancer cases in the implant cohort.

RESULTS

Forty-one patients with implants were subsequently found to have breast cancer. The expected number was 86.2. The standardized incidence ratio was thus 47.6 percent, significantly lower than expected (P less than 0.01). The average length of follow-up in the implant cohort was 10.2 years, and the average length of time from breast augmentation to the diagnosis of breast cancer was 7.5 years.

CONCLUSIONS

Women who undergo breast augmentation with silicone implants have a lower risk of breast cancer than the general population. This finding suggests that these women are drawn from a population already at low risk and that the implants do not substantially increase the risk.

Authors+Show Affiliations

Division of Epidemiology and Preventive Oncology, Alberta Cancer Board, Edmonton, Canada.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

1588977

Citation

Berkel, H, et al. "Breast Augmentation: a Risk Factor for Breast Cancer?" The New England Journal of Medicine, vol. 326, no. 25, 1992, pp. 1649-53.
Berkel H, Birdsell DC, Jenkins H. Breast augmentation: a risk factor for breast cancer? N Engl J Med. 1992;326(25):1649-53.
Berkel, H., Birdsell, D. C., & Jenkins, H. (1992). Breast augmentation: a risk factor for breast cancer? The New England Journal of Medicine, 326(25), 1649-53.
Berkel H, Birdsell DC, Jenkins H. Breast Augmentation: a Risk Factor for Breast Cancer. N Engl J Med. 1992 Jun 18;326(25):1649-53. PubMed PMID: 1588977.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Breast augmentation: a risk factor for breast cancer? AU - Berkel,H, AU - Birdsell,D C, AU - Jenkins,H, PY - 1992/6/18/pubmed PY - 1992/6/18/medline PY - 1992/6/18/entrez SP - 1649 EP - 53 JF - The New England journal of medicine JO - N Engl J Med VL - 326 IS - 25 N2 - BACKGROUND: A relation between breast augmentation and the subsequent risk of breast cancer has been postulated. Since an estimated 2 million women in the United States alone have received breast implants, even a small increase in the risk of breast cancer could have considerable public health consequences. METHODS: We performed a population-based nonconcurrent cohort-linkage study. All women in Alberta, Canada, who underwent cosmetic breast augmentation from 1973 through 1986 were included in the implant cohort (n = 11,676). This cohort was compared with the cohort of all women in Alberta in whom a first primary breast cancer was diagnosed (n = 13,557). The expected number of breast-cancer cases in the implant cohort was estimated by applying age-specific and calendar year--specific incidence rates of breast cancer (obtained from the Alberta Cancer Registry) to the implant cohort. Standardized incidence ratios were calculated by dividing the observed by the expected number of breast-cancer cases in the implant cohort. RESULTS: Forty-one patients with implants were subsequently found to have breast cancer. The expected number was 86.2. The standardized incidence ratio was thus 47.6 percent, significantly lower than expected (P less than 0.01). The average length of follow-up in the implant cohort was 10.2 years, and the average length of time from breast augmentation to the diagnosis of breast cancer was 7.5 years. CONCLUSIONS: Women who undergo breast augmentation with silicone implants have a lower risk of breast cancer than the general population. This finding suggests that these women are drawn from a population already at low risk and that the implants do not substantially increase the risk. SN - 0028-4793 UR - https://www.unboundmedicine.com/medline/citation/1588977/Breast_augmentation:_a_risk_factor_for_breast_cancer DB - PRIME DP - Unbound Medicine ER -