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HIV-dementia, Tat-induced oxidative stress, and antioxidant therapeutic considerations.
Brain Res Brain Res Rev. 2005 Dec 01; 50(1):14-26.BR

Abstract

Oxidative stress is thought to play a role in the onset of dementia. HIV-dementia has recently been demonstrated to be associated with oxidative stress as indexed by increased protein and lipid peroxidation in the brain and cerebrospinal fluid compared to HIV non-demented patients. The HIV protein Tat induces neurotoxicity, and, more recently, Tat was found to induce oxidative stress directly and indirectly. The role of Tat in HIV-dementia and possible therapeutic strategies involving endogenous and exogenous antioxidants are discussed.

Authors+Show Affiliations

Department of Chemistry, University of Kentucky, Lexington, KY 40506, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Review

Language

eng

PubMed ID

15890409

Citation

Pocernich, Chava B., et al. "HIV-dementia, Tat-induced Oxidative Stress, and Antioxidant Therapeutic Considerations." Brain Research. Brain Research Reviews, vol. 50, no. 1, 2005, pp. 14-26.
Pocernich CB, Sultana R, Mohmmad-Abdul H, et al. HIV-dementia, Tat-induced oxidative stress, and antioxidant therapeutic considerations. Brain Res Brain Res Rev. 2005;50(1):14-26.
Pocernich, C. B., Sultana, R., Mohmmad-Abdul, H., Nath, A., & Butterfield, D. A. (2005). HIV-dementia, Tat-induced oxidative stress, and antioxidant therapeutic considerations. Brain Research. Brain Research Reviews, 50(1), 14-26.
Pocernich CB, et al. HIV-dementia, Tat-induced Oxidative Stress, and Antioxidant Therapeutic Considerations. Brain Res Brain Res Rev. 2005 Dec 1;50(1):14-26. PubMed PMID: 15890409.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - HIV-dementia, Tat-induced oxidative stress, and antioxidant therapeutic considerations. AU - Pocernich,Chava B, AU - Sultana,Rukhsana, AU - Mohmmad-Abdul,Hafiz, AU - Nath,Avindra, AU - Butterfield,D Allan, PY - 2004/08/31/received PY - 2005/03/30/revised PY - 2005/04/04/accepted PY - 2005/5/14/pubmed PY - 2006/3/31/medline PY - 2005/5/14/entrez SP - 14 EP - 26 JF - Brain research. Brain research reviews JO - Brain Res Brain Res Rev VL - 50 IS - 1 N2 - Oxidative stress is thought to play a role in the onset of dementia. HIV-dementia has recently been demonstrated to be associated with oxidative stress as indexed by increased protein and lipid peroxidation in the brain and cerebrospinal fluid compared to HIV non-demented patients. The HIV protein Tat induces neurotoxicity, and, more recently, Tat was found to induce oxidative stress directly and indirectly. The role of Tat in HIV-dementia and possible therapeutic strategies involving endogenous and exogenous antioxidants are discussed. UR - https://www.unboundmedicine.com/medline/citation/15890409/HIV_dementia_Tat_induced_oxidative_stress_and_antioxidant_therapeutic_considerations_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0165-0173(05)00052-4 DB - PRIME DP - Unbound Medicine ER -