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Delayed response and lack of habituation in plasma interleukin-6 to acute mental stress in men.
Brain Behav Immun. 2006 Jan; 20(1):40-8.BB

Abstract

Acute mental stress induces a significant increase in plasma interleukin (IL)-6 levels as a possible mechanism for how psychological stress might contribute to atherosclerosis. We investigated whether the IL-6 response would habituate in response to a repetitively applied mental stressor and whether cortisol reactivity would show a relationship with IL-6 reactivity. Study participants were 21 reasonably healthy men (mean age 46+/-7 years) who underwent the Trier Social Stress Test (combination of a 3-min preparation, 5-min speech, and 5-min mental arithmetic) three times with an interval of 1 week. Plasma IL-6 and free salivary cortisol were measured immediately before and after stress, and at 45 and 105 min of recovery from stress. Cortisol samples were also obtained 15 and 30 min after stress. Compared to non-stressed controls, IL-6 significantly increased between rest and 45 min post-stress (p=.022) and between rest and 105 min post-stress (p=.001). Peak cortisol (p=.034) and systolic blood pressure (p=.009) responses to stress both habituated between weeks one and three. No adaptation occurred in diastolic blood pressure, heart rate, and IL-6 responses to stress. The areas under the curve integrating the stress-induced changes in cortisol and IL-6 reactivity were negatively correlated at visit three (r=-.54, p=.011), but not at visit one. The IL-6 response to acute mental stress occurs delayed and shows no adaptation to repeated moderate mental stress. The hypothalamus-pituitary-adrenal axis may attenuate stress reactivity of IL-6. The lack of habituation in IL-6 responses to daily stress could subject at-risk individuals to higher atherosclerotic morbidity and mortality.

Authors+Show Affiliations

Department of General Internal Medicine, Division of Psychosomatic Medicine, University Hospital Berne, Switzerland. roland.vonkaenel@insel.chNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15890495

Citation

von Känel, Roland, et al. "Delayed Response and Lack of Habituation in Plasma Interleukin-6 to Acute Mental Stress in Men." Brain, Behavior, and Immunity, vol. 20, no. 1, 2006, pp. 40-8.
von Känel R, Kudielka BM, Preckel D, et al. Delayed response and lack of habituation in plasma interleukin-6 to acute mental stress in men. Brain Behav Immun. 2006;20(1):40-8.
von Känel, R., Kudielka, B. M., Preckel, D., Hanebuth, D., & Fischer, J. E. (2006). Delayed response and lack of habituation in plasma interleukin-6 to acute mental stress in men. Brain, Behavior, and Immunity, 20(1), 40-8.
von Känel R, et al. Delayed Response and Lack of Habituation in Plasma Interleukin-6 to Acute Mental Stress in Men. Brain Behav Immun. 2006;20(1):40-8. PubMed PMID: 15890495.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Delayed response and lack of habituation in plasma interleukin-6 to acute mental stress in men. AU - von Känel,Roland, AU - Kudielka,Brigitte M, AU - Preckel,Daniel, AU - Hanebuth,Dirk, AU - Fischer,Joachim E, PY - 2004/10/04/received PY - 2005/02/15/revised PY - 2005/03/27/accepted PY - 2005/5/14/pubmed PY - 2006/3/10/medline PY - 2005/5/14/entrez SP - 40 EP - 8 JF - Brain, behavior, and immunity JO - Brain Behav Immun VL - 20 IS - 1 N2 - Acute mental stress induces a significant increase in plasma interleukin (IL)-6 levels as a possible mechanism for how psychological stress might contribute to atherosclerosis. We investigated whether the IL-6 response would habituate in response to a repetitively applied mental stressor and whether cortisol reactivity would show a relationship with IL-6 reactivity. Study participants were 21 reasonably healthy men (mean age 46+/-7 years) who underwent the Trier Social Stress Test (combination of a 3-min preparation, 5-min speech, and 5-min mental arithmetic) three times with an interval of 1 week. Plasma IL-6 and free salivary cortisol were measured immediately before and after stress, and at 45 and 105 min of recovery from stress. Cortisol samples were also obtained 15 and 30 min after stress. Compared to non-stressed controls, IL-6 significantly increased between rest and 45 min post-stress (p=.022) and between rest and 105 min post-stress (p=.001). Peak cortisol (p=.034) and systolic blood pressure (p=.009) responses to stress both habituated between weeks one and three. No adaptation occurred in diastolic blood pressure, heart rate, and IL-6 responses to stress. The areas under the curve integrating the stress-induced changes in cortisol and IL-6 reactivity were negatively correlated at visit three (r=-.54, p=.011), but not at visit one. The IL-6 response to acute mental stress occurs delayed and shows no adaptation to repeated moderate mental stress. The hypothalamus-pituitary-adrenal axis may attenuate stress reactivity of IL-6. The lack of habituation in IL-6 responses to daily stress could subject at-risk individuals to higher atherosclerotic morbidity and mortality. SN - 0889-1591 UR - https://www.unboundmedicine.com/medline/citation/15890495/Delayed_response_and_lack_of_habituation_in_plasma_interleukin_6_to_acute_mental_stress_in_men_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0889-1591(05)00064-4 DB - PRIME DP - Unbound Medicine ER -