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Prolongation of follicular phase by delaying hCG administration results in a higher incidence of endometrial advancement on the day of oocyte retrieval in GnRH antagonist cycles.
Hum Reprod. 2005 Sep; 20(9):2453-6.HR

Abstract

BACKGROUND

Prolongation of follicular phase by delaying hCG administration has been reported to result in a significantly lower ongoing pregnancy rate that did not seem to be due to an embryonic factor. The aim of this prospective randomized study was to assess the effect of delaying hCG administration on endometrial histology.

METHODS

Ten oocyte donors underwent endometrial biopsy on the day of oocyte retrieval and endometrial histology was assessed by Noyes' criteria. Ovarian stimulation was performed with recombinant (r)FSH and daily GnRH antagonist starting on day 6 of stimulation. Patients were randomized by a computer-generated list to receive 10 000 IU of hCG either as soon as > or =3 follicles > or =17 mm were present on ultrasound (early-hCG group, n = 5) or 2 days after this criterion was met (late-hCG group, n = 5).

RESULTS

When hCG was delayed, endometrial advancement was present in all samples examined (median advancement 3 days, range 2-3 days). On the contrary, no secretory changes were observed when the follicular phase was not prolonged (difference in the proportion of patients with advancement between the early-hCG and the late-hCG group: 100%, 95% CI: 38-100).

CONCLUSIONS

Prolongation of follicular phase by delaying hCG administration results in a higher incidence of endometrial advancement on the day of oocyte retrieval in GnRH antagonist cycles.

Authors+Show Affiliations

Centre for Reproductive Medicine, Dutch-speaking Brussels Free University, Belgium. stratis.kolibianakis@otenet.grNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15890735

Citation

Kolibianakis, Efstratios M., et al. "Prolongation of Follicular Phase By Delaying hCG Administration Results in a Higher Incidence of Endometrial Advancement On the Day of Oocyte Retrieval in GnRH Antagonist Cycles." Human Reproduction (Oxford, England), vol. 20, no. 9, 2005, pp. 2453-6.
Kolibianakis EM, Bourgain C, Papanikolaou EG, et al. Prolongation of follicular phase by delaying hCG administration results in a higher incidence of endometrial advancement on the day of oocyte retrieval in GnRH antagonist cycles. Hum Reprod. 2005;20(9):2453-6.
Kolibianakis, E. M., Bourgain, C., Papanikolaou, E. G., Camus, M., Tournaye, H., Van Steirteghem, A. C., & Devroey, P. (2005). Prolongation of follicular phase by delaying hCG administration results in a higher incidence of endometrial advancement on the day of oocyte retrieval in GnRH antagonist cycles. Human Reproduction (Oxford, England), 20(9), 2453-6.
Kolibianakis EM, et al. Prolongation of Follicular Phase By Delaying hCG Administration Results in a Higher Incidence of Endometrial Advancement On the Day of Oocyte Retrieval in GnRH Antagonist Cycles. Hum Reprod. 2005;20(9):2453-6. PubMed PMID: 15890735.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prolongation of follicular phase by delaying hCG administration results in a higher incidence of endometrial advancement on the day of oocyte retrieval in GnRH antagonist cycles. AU - Kolibianakis,Efstratios M, AU - Bourgain,Claire, AU - Papanikolaou,Evangelos G, AU - Camus,Michel, AU - Tournaye,Herman, AU - Van Steirteghem,André C, AU - Devroey,Paul, Y1 - 2005/05/12/ PY - 2005/5/14/pubmed PY - 2005/10/21/medline PY - 2005/5/14/entrez SP - 2453 EP - 6 JF - Human reproduction (Oxford, England) JO - Hum. Reprod. VL - 20 IS - 9 N2 - BACKGROUND: Prolongation of follicular phase by delaying hCG administration has been reported to result in a significantly lower ongoing pregnancy rate that did not seem to be due to an embryonic factor. The aim of this prospective randomized study was to assess the effect of delaying hCG administration on endometrial histology. METHODS: Ten oocyte donors underwent endometrial biopsy on the day of oocyte retrieval and endometrial histology was assessed by Noyes' criteria. Ovarian stimulation was performed with recombinant (r)FSH and daily GnRH antagonist starting on day 6 of stimulation. Patients were randomized by a computer-generated list to receive 10 000 IU of hCG either as soon as > or =3 follicles > or =17 mm were present on ultrasound (early-hCG group, n = 5) or 2 days after this criterion was met (late-hCG group, n = 5). RESULTS: When hCG was delayed, endometrial advancement was present in all samples examined (median advancement 3 days, range 2-3 days). On the contrary, no secretory changes were observed when the follicular phase was not prolonged (difference in the proportion of patients with advancement between the early-hCG and the late-hCG group: 100%, 95% CI: 38-100). CONCLUSIONS: Prolongation of follicular phase by delaying hCG administration results in a higher incidence of endometrial advancement on the day of oocyte retrieval in GnRH antagonist cycles. SN - 0268-1161 UR - https://www.unboundmedicine.com/medline/citation/15890735/Prolongation_of_follicular_phase_by_delaying_hCG_administration_results_in_a_higher_incidence_of_endometrial_advancement_on_the_day_of_oocyte_retrieval_in_GnRH_antagonist_cycles_ L2 - https://academic.oup.com/humrep/article-lookup/doi/10.1093/humrep/dei069 DB - PRIME DP - Unbound Medicine ER -