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Vitamin D receptor FokI genotype influences bone mineral density response to strength training, but not aerobic training.
Exp Physiol. 2005 Jul; 90(4):653-61.EP

Abstract

To determine the influence of the vitamin D receptor (VDR) gene FokI and BsmI genotype on bone mineral density response to two exercise training modalities, 206 healthy men and women (50-81 years old) were studied before and after approximately 5-6 months of either aerobic exercise training (AT) or strength training (ST). A totla of 123 subjects completed AT (51 men, 72 women) and 83 subjects completed ST (40 men, 43 women). DNA was extracted from blood samples of all subjects and genotyping was performed at the VDR FokI and BsmI locus to determine its association to training response. Total body, greater trochanter and femoral neck bone mineral density (BMD) were measured before and after both training programmes using dual-energy X-ray absorptiometry. VDR BsmI genotype was not significantly related to BMD at baseline or after ST or AT. However, VDR FokI genotype was significantly related to ST- but not AT-induced changes in femoral neck BMD (P < 0.05). The heterozygotes (Ff) in the ST group approached a significantly greater increase in femoral neck BMD (P = 0.058) compared to f homozygotes. There were no significant genotype relationships in the AT group. These data indicate that VDR FokI genotype may influence femoral neck BMD response to ST, but not AT.

Authors+Show Affiliations

Rabon-Stith KM
Department of Kinesiology, University of Maryland, College Park, MD 20742, USA. kstith@umd.edu
Hagberg JM
No affiliation info available
Phares DA
No affiliation info available
Kostek MC
No affiliation info available
Delmonico MJ
No affiliation info available
Roth SM
No affiliation info available
Ferrell RE
No affiliation info available
Conway JM
No affiliation info available
Ryan AS
No affiliation info available
Hurley BF
No affiliation info available

MeSH

Absorptiometry, PhotonAerobiosisAgedAged, 80 and overAnaerobiosisBone DensityDNADeoxyribonucleases, Type II Site-SpecificExerciseFemaleGenotypeHumansMaleMiddle AgedMuscle, SkeletalPhysical FitnessPolymorphism, GeneticReceptors, CalcitriolWeight Lifting

Pub Type(s)

Clinical Trial
Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

15890796

Citation

Rabon-Stith, Karma M., et al. "Vitamin D Receptor FokI Genotype Influences Bone Mineral Density Response to Strength Training, but Not Aerobic Training." Experimental Physiology, vol. 90, no. 4, 2005, pp. 653-61.
Rabon-Stith KM, Hagberg JM, Phares DA, et al. Vitamin D receptor FokI genotype influences bone mineral density response to strength training, but not aerobic training. Exp Physiol. 2005;90(4):653-61.
Rabon-Stith, K. M., Hagberg, J. M., Phares, D. A., Kostek, M. C., Delmonico, M. J., Roth, S. M., Ferrell, R. E., Conway, J. M., Ryan, A. S., & Hurley, B. F. (2005). Vitamin D receptor FokI genotype influences bone mineral density response to strength training, but not aerobic training. Experimental Physiology, 90(4), 653-61.
Rabon-Stith KM, et al. Vitamin D Receptor FokI Genotype Influences Bone Mineral Density Response to Strength Training, but Not Aerobic Training. Exp Physiol. 2005;90(4):653-61. PubMed PMID: 15890796.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Vitamin D receptor FokI genotype influences bone mineral density response to strength training, but not aerobic training. AU - Rabon-Stith,Karma M, AU - Hagberg,James M, AU - Phares,Dana A, AU - Kostek,Matthew C, AU - Delmonico,Matthew J, AU - Roth,Stephen M, AU - Ferrell,Robert E, AU - Conway,Joan M, AU - Ryan,Alice S, AU - Hurley,Ben F, Y1 - 2005/05/12/ PY - 2005/5/14/pubmed PY - 2005/9/22/medline PY - 2005/5/14/entrez SP - 653 EP - 61 JF - Experimental physiology JO - Exp Physiol VL - 90 IS - 4 N2 - To determine the influence of the vitamin D receptor (VDR) gene FokI and BsmI genotype on bone mineral density response to two exercise training modalities, 206 healthy men and women (50-81 years old) were studied before and after approximately 5-6 months of either aerobic exercise training (AT) or strength training (ST). A totla of 123 subjects completed AT (51 men, 72 women) and 83 subjects completed ST (40 men, 43 women). DNA was extracted from blood samples of all subjects and genotyping was performed at the VDR FokI and BsmI locus to determine its association to training response. Total body, greater trochanter and femoral neck bone mineral density (BMD) were measured before and after both training programmes using dual-energy X-ray absorptiometry. VDR BsmI genotype was not significantly related to BMD at baseline or after ST or AT. However, VDR FokI genotype was significantly related to ST- but not AT-induced changes in femoral neck BMD (P < 0.05). The heterozygotes (Ff) in the ST group approached a significantly greater increase in femoral neck BMD (P = 0.058) compared to f homozygotes. There were no significant genotype relationships in the AT group. These data indicate that VDR FokI genotype may influence femoral neck BMD response to ST, but not AT. SN - 0958-0670 UR - https://www.unboundmedicine.com/medline/citation/15890796/Vitamin_D_receptor_FokI_genotype_influences_bone_mineral_density_response_to_strength_training_but_not_aerobic_training_ DB - PRIME DP - Unbound Medicine ER -