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Ganglioneuromatous paraganglioma of the cauda equina--a pathological case study.
Hum Pathol. 2005 Apr; 36(4):444-6.HP

Abstract

This study presents a rare case of compound paraganglioma/ganglioneuroma with comprehensive immunohistochemical studies that reveal strong cytokeratin expression in all components. A 74-year-old woman presented with a mass lesion of the cauda equina. The 1.8-cm tumor showed 3 histomorphologically and immunohistochemically distinct components: typical paragangliomatous neuroendocrine areas, mature ganglion cell-like neuronal areas, and a "neuromatous" proliferation of Schwann cells with admixed axons. As often seen in cauda equina paragangliomas, the neuroendocrine cells were cytokeratin-positive. In addition, immunoreactivity for cytokeratins was also observed in the neurons and axons. This tumor illustrates the broad spectrum of divergent differentiation that can be seen in cells of sympathoadrenal lineage.

Authors+Show Affiliations

Department of Pathology, University of Chicago Hospitals, Chicago, IL 60637, USA.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

15892009

Citation

Pytel, Peter, et al. "Ganglioneuromatous Paraganglioma of the Cauda Equina--a Pathological Case Study." Human Pathology, vol. 36, no. 4, 2005, pp. 444-6.
Pytel P, Krausz T, Wollmann R, et al. Ganglioneuromatous paraganglioma of the cauda equina--a pathological case study. Hum Pathol. 2005;36(4):444-6.
Pytel, P., Krausz, T., Wollmann, R., & Utset, M. F. (2005). Ganglioneuromatous paraganglioma of the cauda equina--a pathological case study. Human Pathology, 36(4), 444-6.
Pytel P, et al. Ganglioneuromatous Paraganglioma of the Cauda Equina--a Pathological Case Study. Hum Pathol. 2005;36(4):444-6. PubMed PMID: 15892009.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Ganglioneuromatous paraganglioma of the cauda equina--a pathological case study. AU - Pytel,Peter, AU - Krausz,Thomas, AU - Wollmann,Robert, AU - Utset,Manuel F, PY - 2005/5/14/pubmed PY - 2005/6/14/medline PY - 2005/5/14/entrez SP - 444 EP - 6 JF - Human pathology JO - Hum. Pathol. VL - 36 IS - 4 N2 - This study presents a rare case of compound paraganglioma/ganglioneuroma with comprehensive immunohistochemical studies that reveal strong cytokeratin expression in all components. A 74-year-old woman presented with a mass lesion of the cauda equina. The 1.8-cm tumor showed 3 histomorphologically and immunohistochemically distinct components: typical paragangliomatous neuroendocrine areas, mature ganglion cell-like neuronal areas, and a "neuromatous" proliferation of Schwann cells with admixed axons. As often seen in cauda equina paragangliomas, the neuroendocrine cells were cytokeratin-positive. In addition, immunoreactivity for cytokeratins was also observed in the neurons and axons. This tumor illustrates the broad spectrum of divergent differentiation that can be seen in cells of sympathoadrenal lineage. SN - 0046-8177 UR - https://www.unboundmedicine.com/medline/citation/15892009/Ganglioneuromatous_paraganglioma_of_the_cauda_equina__a_pathological_case_study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0046817705000523 DB - PRIME DP - Unbound Medicine ER -