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5-Hydroxytryptophan plus SSRIs for interferon-induced depression: synergistic mechanisms for normalizing synaptic serotonin.
Med Hypotheses. 2005; 65(1):138-44.MH

Abstract

Interferon-alpha (IFN) is widely used in the treatment of certain cancers and viral infections, including hepatitis C (HCV). Unfortunately, depression is a common side effect of IFN therapy, affecting approximately a third of HCV patients receiving IFN therapy. Studies have shown that selective serotonin reuptake inhibitors (SSRIs) can effectively treat IFN-induced depression in only 63-75% of cases. For the remaining percentage, depression often necessitates dose reduction of or discontinuation from IFN therapy. Emerging evidence indicates that IFN may cause depression by affecting brain serotonin. IFN has been shown to increase serotonin reuptake and to decrease serotonin synthesis. We hypothesize that SSRIs are not fully effective because they affect only serotonin reuptake, not serotonin synthesis, and that effective treatment must address both uptake and synthesis. 5-Hydroxytryptophan (5-HTP) effectively increases central nervous system synthesis of serotonin. It is the immediate precursor of serotonin and is widely available as a dietary supplement, which is well absorbed after an oral dose. Several double-blind studies have shown 5-HTP to be effective in the treatment of nondrug-induced depression. We hypothesize that patients who become depressed on IFN will respond to the synergistic combination of SSRIs plus 5-HTP.

Authors+Show Affiliations

Mental Health Division, Mood Disorders Research Center, Portland VA Medical Center, 3710 SW US Veterans Hospital Rd., Portland, OR 97239, USA. Erik.turner@med.va.govNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15893130

Citation

Turner, Erick H., and Aaron D. Blackwell. "5-Hydroxytryptophan Plus SSRIs for Interferon-induced Depression: Synergistic Mechanisms for Normalizing Synaptic Serotonin." Medical Hypotheses, vol. 65, no. 1, 2005, pp. 138-44.
Turner EH, Blackwell AD. 5-Hydroxytryptophan plus SSRIs for interferon-induced depression: synergistic mechanisms for normalizing synaptic serotonin. Med Hypotheses. 2005;65(1):138-44.
Turner, E. H., & Blackwell, A. D. (2005). 5-Hydroxytryptophan plus SSRIs for interferon-induced depression: synergistic mechanisms for normalizing synaptic serotonin. Medical Hypotheses, 65(1), 138-44.
Turner EH, Blackwell AD. 5-Hydroxytryptophan Plus SSRIs for Interferon-induced Depression: Synergistic Mechanisms for Normalizing Synaptic Serotonin. Med Hypotheses. 2005;65(1):138-44. PubMed PMID: 15893130.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - 5-Hydroxytryptophan plus SSRIs for interferon-induced depression: synergistic mechanisms for normalizing synaptic serotonin. AU - Turner,Erick H, AU - Blackwell,Aaron D, PY - 2005/01/02/received PY - 2005/01/05/accepted PY - 2005/5/17/pubmed PY - 2005/8/17/medline PY - 2005/5/17/entrez SP - 138 EP - 44 JF - Medical hypotheses JO - Med. Hypotheses VL - 65 IS - 1 N2 - Interferon-alpha (IFN) is widely used in the treatment of certain cancers and viral infections, including hepatitis C (HCV). Unfortunately, depression is a common side effect of IFN therapy, affecting approximately a third of HCV patients receiving IFN therapy. Studies have shown that selective serotonin reuptake inhibitors (SSRIs) can effectively treat IFN-induced depression in only 63-75% of cases. For the remaining percentage, depression often necessitates dose reduction of or discontinuation from IFN therapy. Emerging evidence indicates that IFN may cause depression by affecting brain serotonin. IFN has been shown to increase serotonin reuptake and to decrease serotonin synthesis. We hypothesize that SSRIs are not fully effective because they affect only serotonin reuptake, not serotonin synthesis, and that effective treatment must address both uptake and synthesis. 5-Hydroxytryptophan (5-HTP) effectively increases central nervous system synthesis of serotonin. It is the immediate precursor of serotonin and is widely available as a dietary supplement, which is well absorbed after an oral dose. Several double-blind studies have shown 5-HTP to be effective in the treatment of nondrug-induced depression. We hypothesize that patients who become depressed on IFN will respond to the synergistic combination of SSRIs plus 5-HTP. SN - 0306-9877 UR - https://www.unboundmedicine.com/medline/citation/15893130/5_Hydroxytryptophan_plus_SSRIs_for_interferon_induced_depression:_synergistic_mechanisms_for_normalizing_synaptic_serotonin_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0306-9877(05)00068-X DB - PRIME DP - Unbound Medicine ER -