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Up-regulated phosphorylation of signal transducer and activator of transcription 3 and cyclic AMP-responsive element binding protein by peripheral inflammation in primary afferent neurons possibly through oncostatin M receptor.
Neuroscience. 2005; 133(3):797-806.N

Abstract

Oncostatin M (OSM), a member of interleukin-6 family cytokines, contributes to the development of nociceptive sensory neurons. However, little is known about the role of OSM in dorsal root ganglia (DRGs) of adult mice after peripheral inflammation. In the present study, we showed that OSM mRNA was highly expressed in the inflamed skin during acute inflammation induced by complete Freund's adjuvant (CFA), while the expression of oncostatin M receptor (OSMR) did not change in the ipsilateral DRG. Although peripheral inflammation induced significant increases in the number of neurons with phosphorylated extracellular signal-regulated kinase (p-ERK) and phosphorylated p38 mitogen-activated protein kinase (p-p38) in ipsilateral DRGs, OSMR-positive neurons exhibited neither p-ERK nor p-p38. In addition, we found significant increases in the number of neurons with phosphorylated signal transducer and activator of transcription 3 (p-STAT3) and phosphorylated cAMP-responsive element binding protein (p-CREB) in the ipsilateral DRGs. Interestingly, OSMR-positive neurons with p-STAT3 and p-CREB were significantly increased after peripheral inflammation. Thus, our results suggest that acute inflammation induce the phosphorylations of several signal molecules, including ERK, p38, cAMP-responsive element binding protein, and STAT3. Among them, the up-regulation of p-STAT3 and p-CREB may be induced possibly through OSMR.

Authors+Show Affiliations

Department of Anatomy and Neurobiology, Wakayama Medical University, Kimiidera 811-1, Wakayama 641-8509, Japan.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15893881

Citation

Tamura, S, et al. "Up-regulated Phosphorylation of Signal Transducer and Activator of Transcription 3 and Cyclic AMP-responsive Element Binding Protein By Peripheral Inflammation in Primary Afferent Neurons Possibly Through Oncostatin M Receptor." Neuroscience, vol. 133, no. 3, 2005, pp. 797-806.
Tamura S, Morikawa Y, Senba E. Up-regulated phosphorylation of signal transducer and activator of transcription 3 and cyclic AMP-responsive element binding protein by peripheral inflammation in primary afferent neurons possibly through oncostatin M receptor. Neuroscience. 2005;133(3):797-806.
Tamura, S., Morikawa, Y., & Senba, E. (2005). Up-regulated phosphorylation of signal transducer and activator of transcription 3 and cyclic AMP-responsive element binding protein by peripheral inflammation in primary afferent neurons possibly through oncostatin M receptor. Neuroscience, 133(3), 797-806.
Tamura S, Morikawa Y, Senba E. Up-regulated Phosphorylation of Signal Transducer and Activator of Transcription 3 and Cyclic AMP-responsive Element Binding Protein By Peripheral Inflammation in Primary Afferent Neurons Possibly Through Oncostatin M Receptor. Neuroscience. 2005;133(3):797-806. PubMed PMID: 15893881.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Up-regulated phosphorylation of signal transducer and activator of transcription 3 and cyclic AMP-responsive element binding protein by peripheral inflammation in primary afferent neurons possibly through oncostatin M receptor. AU - Tamura,S, AU - Morikawa,Y, AU - Senba,E, PY - 2004/11/24/received PY - 2005/02/08/revised PY - 2005/02/23/accepted PY - 2005/5/17/pubmed PY - 2005/9/8/medline PY - 2005/5/17/entrez SP - 797 EP - 806 JF - Neuroscience JO - Neuroscience VL - 133 IS - 3 N2 - Oncostatin M (OSM), a member of interleukin-6 family cytokines, contributes to the development of nociceptive sensory neurons. However, little is known about the role of OSM in dorsal root ganglia (DRGs) of adult mice after peripheral inflammation. In the present study, we showed that OSM mRNA was highly expressed in the inflamed skin during acute inflammation induced by complete Freund's adjuvant (CFA), while the expression of oncostatin M receptor (OSMR) did not change in the ipsilateral DRG. Although peripheral inflammation induced significant increases in the number of neurons with phosphorylated extracellular signal-regulated kinase (p-ERK) and phosphorylated p38 mitogen-activated protein kinase (p-p38) in ipsilateral DRGs, OSMR-positive neurons exhibited neither p-ERK nor p-p38. In addition, we found significant increases in the number of neurons with phosphorylated signal transducer and activator of transcription 3 (p-STAT3) and phosphorylated cAMP-responsive element binding protein (p-CREB) in the ipsilateral DRGs. Interestingly, OSMR-positive neurons with p-STAT3 and p-CREB were significantly increased after peripheral inflammation. Thus, our results suggest that acute inflammation induce the phosphorylations of several signal molecules, including ERK, p38, cAMP-responsive element binding protein, and STAT3. Among them, the up-regulation of p-STAT3 and p-CREB may be induced possibly through OSMR. SN - 0306-4522 UR - https://www.unboundmedicine.com/medline/citation/15893881/Up_regulated_phosphorylation_of_signal_transducer_and_activator_of_transcription_3_and_cyclic_AMP_responsive_element_binding_protein_by_peripheral_inflammation_in_primary_afferent_neurons_possibly_through_oncostatin_M_receptor_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0306-4522(05)00285-X DB - PRIME DP - Unbound Medicine ER -