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Prenatal exposure to the Dutch famine and disease in later life: an overview.
Reprod Toxicol 2005 Sep-Oct; 20(3):345-52RT

Abstract

Low birth weight is associated with cardiovascular disease in adulthood. Poor maternal nutrition during gestation contributes to low birth weight. In this paper, we review the findings from a cohort of 2414 people, aged 50 years, born as term singletons around the time of the 1944-1945 Dutch famine, of which 912 people participated in an interview and 741 subjects were also available for hospital examination. We found more coronary heart disease, raised lipids, altered clotting and more obesity after exposure to famine in early gestation compared to those not exposed to the famine. Exposure in mid gestation was associated with obstructive airways disease and microalbuminuria. We found decreased glucose tolerance in people exposed to famine in late gestation. These findings show that maternal undernutrition during gestation has important effects on health in later life, but that the timing of the nutritional insult determines which organ system is affected. Future research should shed more light upon the underlying pathophysiology of the far-reaching effects of prenatal exposure to famine.

Authors+Show Affiliations

Department of Clinical Epidemiology and Biostatistics, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands. r.c.painter@amc.uva.nlNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

15893910

Citation

Painter, Rebecca C., et al. "Prenatal Exposure to the Dutch Famine and Disease in Later Life: an Overview." Reproductive Toxicology (Elmsford, N.Y.), vol. 20, no. 3, 2005, pp. 345-52.
Painter RC, Roseboom TJ, Bleker OP. Prenatal exposure to the Dutch famine and disease in later life: an overview. Reprod Toxicol. 2005;20(3):345-52.
Painter, R. C., Roseboom, T. J., & Bleker, O. P. (2005). Prenatal exposure to the Dutch famine and disease in later life: an overview. Reproductive Toxicology (Elmsford, N.Y.), 20(3), pp. 345-52.
Painter RC, Roseboom TJ, Bleker OP. Prenatal Exposure to the Dutch Famine and Disease in Later Life: an Overview. Reprod Toxicol. 2005;20(3):345-52. PubMed PMID: 15893910.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prenatal exposure to the Dutch famine and disease in later life: an overview. AU - Painter,Rebecca C, AU - Roseboom,Tessa J, AU - Bleker,Otto P, PY - 2005/02/09/received PY - 2005/03/30/revised PY - 2005/04/01/accepted PY - 2005/5/17/pubmed PY - 2005/9/28/medline PY - 2005/5/17/entrez SP - 345 EP - 52 JF - Reproductive toxicology (Elmsford, N.Y.) JO - Reprod. Toxicol. VL - 20 IS - 3 N2 - Low birth weight is associated with cardiovascular disease in adulthood. Poor maternal nutrition during gestation contributes to low birth weight. In this paper, we review the findings from a cohort of 2414 people, aged 50 years, born as term singletons around the time of the 1944-1945 Dutch famine, of which 912 people participated in an interview and 741 subjects were also available for hospital examination. We found more coronary heart disease, raised lipids, altered clotting and more obesity after exposure to famine in early gestation compared to those not exposed to the famine. Exposure in mid gestation was associated with obstructive airways disease and microalbuminuria. We found decreased glucose tolerance in people exposed to famine in late gestation. These findings show that maternal undernutrition during gestation has important effects on health in later life, but that the timing of the nutritional insult determines which organ system is affected. Future research should shed more light upon the underlying pathophysiology of the far-reaching effects of prenatal exposure to famine. SN - 0890-6238 UR - https://www.unboundmedicine.com/medline/citation/15893910/Prenatal_exposure_to_the_Dutch_famine_and_disease_in_later_life:_an_overview_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0890-6238(05)00088-2 DB - PRIME DP - Unbound Medicine ER -