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Anti-inflammatory and analgesic properties of water-ethanolic extract from Pothomorphe umbellata (Piperaceae) aerial parts.
J Ethnopharmacol. 2005 Jun 03; 99(2):215-20.JE

Abstract

Anti-inflammatory and analgesic activities as well as the median lethal dose (LD50) of water-ethanolic extract (PHE) of the aerial parts of Pothomorphe umbellata were evaluated in animal models. The ED(50) (oral) for the inhibition of carrageenan-induced rat paw edema assay was determined to be 550 mg/kg, while the LD(50) was higher than 2.0 g/kg. At a dose of 550 mg/kg, PHE inhibited the inflammatory process by 48.7% (P < 0.05) on the third hour of the assay (edema peak) when compared to the untreated control. Indomethacin, the positive control used in this test, inhibited the edema by 58.6% at a dose of 10 mg/kg, when compared to the untreated control (P < 0.05). All three fractions--hexane, methylene chloride and ethyl acetate--obtained by partition of PHE with respective solvents also showed inhibition of the edema induced by carrageenan over a period of 4h but the methylene chloride fraction showed the best activity. The activity shown by the methylene chloride fraction at 200 mg/kg was comparable to that exhibited by indomethacin at a dose of 10mg/kg. The number of writhings induced by a 0.6% acetic acid solution intraperitoneal injection was decreased by 22% (P < 0.05) in the group treated orally with Pothomorphe umbellata crude extract. PHE also inhibited the granulomatous tissue formation in rats by 6.2% (P < 0.05). In the same assay, topically applied dexamethasone decreased the granuloma formation by 14.2%. The above results suggest that Pothomorphe umbellata crude extract has analgesic and anti-inflammatory properties supporting its folkloric use for the treatment of these conditions.

Authors+Show Affiliations

Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Av. do Café s/n, Ribeirão Preto 14040-903, SP, Brazil.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15894130

Citation

Perazzo, Fabio F., et al. "Anti-inflammatory and Analgesic Properties of Water-ethanolic Extract From Pothomorphe Umbellata (Piperaceae) Aerial Parts." Journal of Ethnopharmacology, vol. 99, no. 2, 2005, pp. 215-20.
Perazzo FF, Souza GH, Lopes W, et al. Anti-inflammatory and analgesic properties of water-ethanolic extract from Pothomorphe umbellata (Piperaceae) aerial parts. J Ethnopharmacol. 2005;99(2):215-20.
Perazzo, F. F., Souza, G. H., Lopes, W., Cardoso, L. G., Carvalho, J. C., Nanayakkara, N. P., & Bastos, J. K. (2005). Anti-inflammatory and analgesic properties of water-ethanolic extract from Pothomorphe umbellata (Piperaceae) aerial parts. Journal of Ethnopharmacology, 99(2), 215-20.
Perazzo FF, et al. Anti-inflammatory and Analgesic Properties of Water-ethanolic Extract From Pothomorphe Umbellata (Piperaceae) Aerial Parts. J Ethnopharmacol. 2005 Jun 3;99(2):215-20. PubMed PMID: 15894130.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Anti-inflammatory and analgesic properties of water-ethanolic extract from Pothomorphe umbellata (Piperaceae) aerial parts. AU - Perazzo,Fabio F, AU - Souza,Gustavo H B, AU - Lopes,Walter, AU - Cardoso,Luis G V, AU - Carvalho,Jose C T, AU - Nanayakkara,N P Dhammika, AU - Bastos,Jairo K, Y1 - 2005/04/12/ PY - 2004/07/01/received PY - 2005/01/14/revised PY - 2005/02/08/accepted PY - 2005/5/17/pubmed PY - 2005/9/2/medline PY - 2005/5/17/entrez SP - 215 EP - 20 JF - Journal of ethnopharmacology JO - J Ethnopharmacol VL - 99 IS - 2 N2 - Anti-inflammatory and analgesic activities as well as the median lethal dose (LD50) of water-ethanolic extract (PHE) of the aerial parts of Pothomorphe umbellata were evaluated in animal models. The ED(50) (oral) for the inhibition of carrageenan-induced rat paw edema assay was determined to be 550 mg/kg, while the LD(50) was higher than 2.0 g/kg. At a dose of 550 mg/kg, PHE inhibited the inflammatory process by 48.7% (P < 0.05) on the third hour of the assay (edema peak) when compared to the untreated control. Indomethacin, the positive control used in this test, inhibited the edema by 58.6% at a dose of 10 mg/kg, when compared to the untreated control (P < 0.05). All three fractions--hexane, methylene chloride and ethyl acetate--obtained by partition of PHE with respective solvents also showed inhibition of the edema induced by carrageenan over a period of 4h but the methylene chloride fraction showed the best activity. The activity shown by the methylene chloride fraction at 200 mg/kg was comparable to that exhibited by indomethacin at a dose of 10mg/kg. The number of writhings induced by a 0.6% acetic acid solution intraperitoneal injection was decreased by 22% (P < 0.05) in the group treated orally with Pothomorphe umbellata crude extract. PHE also inhibited the granulomatous tissue formation in rats by 6.2% (P < 0.05). In the same assay, topically applied dexamethasone decreased the granuloma formation by 14.2%. The above results suggest that Pothomorphe umbellata crude extract has analgesic and anti-inflammatory properties supporting its folkloric use for the treatment of these conditions. SN - 0378-8741 UR - https://www.unboundmedicine.com/medline/citation/15894130/Anti_inflammatory_and_analgesic_properties_of_water_ethanolic_extract_from_Pothomorphe_umbellata__Piperaceae__aerial_parts_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-8741(05)00152-2 DB - PRIME DP - Unbound Medicine ER -