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Punica granatum flower extract, a potent alpha-glucosidase inhibitor, improves postprandial hyperglycemia in Zucker diabetic fatty rats.
J Ethnopharmacol. 2005 Jun 03; 99(2):239-44.JE

Abstract

Postprandial hyperglycemia plays an important role in the development of type 2 diabetes and has been proposed as an independent risk factor for cardiovascular diseases. The flowering part of Punica granatum Linn. (Punicaceae) (PGF) has been recommended in Unani literature as a remedy for diabetes. We investigated the effect and action mechanism of a methanolic extract from PGF on hyperglycemia in vivo and in vitro. Oral administration of PGF extract markedly lowered plasma glucose levels in non-fasted Zucker diabetic fatty rats (a genetic model of obesity and type 2 diabetes), whereas it had little effect in the fasted animals, suggesting it affected postprandial hyperglycemia in type 2 diabetes. In support of this conclusion the extract was found to markedly inhibit the increase of plasma glucose levels after sucrose loading, but not after glucose loading in mice, and it had no effect on glucose levels in normal mice. In vitro, PGF extract demonstrated a potent inhibitory effect on alpha-glucosidase activity (IC50: 1.8 microg/ml). The inhibition is dependent on the concentration of enzyme and substrate, as well as on the length of pretreatment with the enzyme. These findings strongly suggest that PGF extract improves postprandial hyperglycemia in type 2 diabetes and obesity, at least in part, by inhibiting intestinal alpha-glucosidase activity.

Authors+Show Affiliations

Herbal Medicines Research and Education Centre, Faculty of Pharmacy, A15, The University of Sydney, Sydney, NSW 2006, Australia. yuhao@pharm.usyd.edu.auNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15894133

Citation

Li, Yuhao, et al. "Punica Granatum Flower Extract, a Potent Alpha-glucosidase Inhibitor, Improves Postprandial Hyperglycemia in Zucker Diabetic Fatty Rats." Journal of Ethnopharmacology, vol. 99, no. 2, 2005, pp. 239-44.
Li Y, Wen S, Kota BP, et al. Punica granatum flower extract, a potent alpha-glucosidase inhibitor, improves postprandial hyperglycemia in Zucker diabetic fatty rats. J Ethnopharmacol. 2005;99(2):239-44.
Li, Y., Wen, S., Kota, B. P., Peng, G., Li, G. Q., Yamahara, J., & Roufogalis, B. D. (2005). Punica granatum flower extract, a potent alpha-glucosidase inhibitor, improves postprandial hyperglycemia in Zucker diabetic fatty rats. Journal of Ethnopharmacology, 99(2), 239-44.
Li Y, et al. Punica Granatum Flower Extract, a Potent Alpha-glucosidase Inhibitor, Improves Postprandial Hyperglycemia in Zucker Diabetic Fatty Rats. J Ethnopharmacol. 2005 Jun 3;99(2):239-44. PubMed PMID: 15894133.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Punica granatum flower extract, a potent alpha-glucosidase inhibitor, improves postprandial hyperglycemia in Zucker diabetic fatty rats. AU - Li,Yuhao, AU - Wen,Suping, AU - Kota,Bhavani Prasad, AU - Peng,Gang, AU - Li,George Qian, AU - Yamahara,Johji, AU - Roufogalis,Basil D, Y1 - 2005/04/09/ PY - 2004/11/02/received PY - 2005/01/12/revised PY - 2005/02/12/accepted PY - 2005/5/17/pubmed PY - 2005/9/2/medline PY - 2005/5/17/entrez SP - 239 EP - 44 JF - Journal of ethnopharmacology JO - J Ethnopharmacol VL - 99 IS - 2 N2 - Postprandial hyperglycemia plays an important role in the development of type 2 diabetes and has been proposed as an independent risk factor for cardiovascular diseases. The flowering part of Punica granatum Linn. (Punicaceae) (PGF) has been recommended in Unani literature as a remedy for diabetes. We investigated the effect and action mechanism of a methanolic extract from PGF on hyperglycemia in vivo and in vitro. Oral administration of PGF extract markedly lowered plasma glucose levels in non-fasted Zucker diabetic fatty rats (a genetic model of obesity and type 2 diabetes), whereas it had little effect in the fasted animals, suggesting it affected postprandial hyperglycemia in type 2 diabetes. In support of this conclusion the extract was found to markedly inhibit the increase of plasma glucose levels after sucrose loading, but not after glucose loading in mice, and it had no effect on glucose levels in normal mice. In vitro, PGF extract demonstrated a potent inhibitory effect on alpha-glucosidase activity (IC50: 1.8 microg/ml). The inhibition is dependent on the concentration of enzyme and substrate, as well as on the length of pretreatment with the enzyme. These findings strongly suggest that PGF extract improves postprandial hyperglycemia in type 2 diabetes and obesity, at least in part, by inhibiting intestinal alpha-glucosidase activity. SN - 0378-8741 UR - https://www.unboundmedicine.com/medline/citation/15894133/Punica_granatum_flower_extract_a_potent_alpha_glucosidase_inhibitor_improves_postprandial_hyperglycemia_in_Zucker_diabetic_fatty_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-8741(05)00207-2 DB - PRIME DP - Unbound Medicine ER -