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Comorbid psychiatric disorders in depressed outpatients: demographic and clinical features.
J Affect Disord. 2005 Jul; 87(1):43-55.JA

Abstract

BACKGROUND

This study evaluated the clinical and sociodemographic features associated with various degrees of concurrent comorbidity in adult outpatients with nonpsychotic major depressive disorder (MDD).

METHODS

Outpatients enrolled in the STAR*D trial completed the Psychiatric Diagnostic Screening Questionnaire (PDSQ). An a priori 90% specificity threshold was set for PDSQ responses to ascertain the presence of 11 different concurrent DSM-IV Axis I disorders.

RESULTS

Of 1376 outpatients, 38.2% had no concurrent comorbidities, while 25.6% suffered one, 16.1% suffered two, and 20.2% suffered three or more comorbid conditions. Altogether, 29.3% met threshold for social anxiety disorder, 20.8% for generalized anxiety disorder, 18.8% for posttraumatic stress disorder, 12.4% for bulimia, 11.9% for alcohol abuse/dependence, 13.4% for obsessive-compulsive disorder, 11.1% for panic disorder, 9.4% for agoraphobia, 7.3% for drug abuse/dependence, 3.7% for hypochondriasis, and 2.2% for somatoform disorder. Those with more concurrent Axis I conditions had earlier ages at first onset of MDD, longer histories of MDD, greater depressive symptom severity, more general medical comorbidity (even though they were younger than those with fewer comorbid conditions), poorer physical and mental function, health perceptions, and life satisfaction; and were more likely to be seen in primary care settings.

LIMITATIONS

Participants had to meet entry criteria for STAR*D. Ascertainment of comorbid conditions was not based on a structured interview.

CONCLUSIONS

Concurrent Axis I conditions (most often anxiety disorders) are very common with MDD. Greater numbers of concurrent comorbid conditions were associated with increased severity, morbidity, and chronicity of their MDD.

Authors+Show Affiliations

Department of Psychiatry, The University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390-9086, USA. john.rush@utsouthwestern.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

15894381

Citation

Rush, A John, et al. "Comorbid Psychiatric Disorders in Depressed Outpatients: Demographic and Clinical Features." Journal of Affective Disorders, vol. 87, no. 1, 2005, pp. 43-55.
Rush AJ, Zimmerman M, Wisniewski SR, et al. Comorbid psychiatric disorders in depressed outpatients: demographic and clinical features. J Affect Disord. 2005;87(1):43-55.
Rush, A. J., Zimmerman, M., Wisniewski, S. R., Fava, M., Hollon, S. D., Warden, D., Biggs, M. M., Shores-Wilson, K., Shelton, R. C., Luther, J. F., Thomas, B., & Trivedi, M. H. (2005). Comorbid psychiatric disorders in depressed outpatients: demographic and clinical features. Journal of Affective Disorders, 87(1), 43-55.
Rush AJ, et al. Comorbid Psychiatric Disorders in Depressed Outpatients: Demographic and Clinical Features. J Affect Disord. 2005;87(1):43-55. PubMed PMID: 15894381.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comorbid psychiatric disorders in depressed outpatients: demographic and clinical features. AU - Rush,A John, AU - Zimmerman,Mark, AU - Wisniewski,Stephen R, AU - Fava,Maurizio, AU - Hollon,Steven D, AU - Warden,Diane, AU - Biggs,Melanie M, AU - Shores-Wilson,Kathy, AU - Shelton,Richard C, AU - Luther,James F, AU - Thomas,Brandi, AU - Trivedi,Madhukar H, PY - 2004/10/06/received PY - 2005/03/02/accepted PY - 2005/5/17/pubmed PY - 2005/10/20/medline PY - 2005/5/17/entrez SP - 43 EP - 55 JF - Journal of affective disorders JO - J Affect Disord VL - 87 IS - 1 N2 - BACKGROUND: This study evaluated the clinical and sociodemographic features associated with various degrees of concurrent comorbidity in adult outpatients with nonpsychotic major depressive disorder (MDD). METHODS: Outpatients enrolled in the STAR*D trial completed the Psychiatric Diagnostic Screening Questionnaire (PDSQ). An a priori 90% specificity threshold was set for PDSQ responses to ascertain the presence of 11 different concurrent DSM-IV Axis I disorders. RESULTS: Of 1376 outpatients, 38.2% had no concurrent comorbidities, while 25.6% suffered one, 16.1% suffered two, and 20.2% suffered three or more comorbid conditions. Altogether, 29.3% met threshold for social anxiety disorder, 20.8% for generalized anxiety disorder, 18.8% for posttraumatic stress disorder, 12.4% for bulimia, 11.9% for alcohol abuse/dependence, 13.4% for obsessive-compulsive disorder, 11.1% for panic disorder, 9.4% for agoraphobia, 7.3% for drug abuse/dependence, 3.7% for hypochondriasis, and 2.2% for somatoform disorder. Those with more concurrent Axis I conditions had earlier ages at first onset of MDD, longer histories of MDD, greater depressive symptom severity, more general medical comorbidity (even though they were younger than those with fewer comorbid conditions), poorer physical and mental function, health perceptions, and life satisfaction; and were more likely to be seen in primary care settings. LIMITATIONS: Participants had to meet entry criteria for STAR*D. Ascertainment of comorbid conditions was not based on a structured interview. CONCLUSIONS: Concurrent Axis I conditions (most often anxiety disorders) are very common with MDD. Greater numbers of concurrent comorbid conditions were associated with increased severity, morbidity, and chronicity of their MDD. SN - 0165-0327 UR - https://www.unboundmedicine.com/medline/citation/15894381/Comorbid_psychiatric_disorders_in_depressed_outpatients:_demographic_and_clinical_features_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0165-0327(05)00078-9 DB - PRIME DP - Unbound Medicine ER -