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alpha-Synuclein-immunoreactive structure formation is enhanced in sympathetic ganglia of patients with multiple system atrophy.
Acta Neuropathol. 2005 Jul; 110(1):19-26.AN

Abstract

We immunohistochemically examined the sympathetic ganglia (SG) and brains of 26 patients with multiple system atrophy (MSA), 19 age-matched controls, and 25 patients with amyotrophic lateral sclerosis (ALS). alpha-Synuclein-immunoreactive structures were found in the neuronal cytoplasm and processes of the SG in 11 of the 26 MSA cases (42.3%) and 1 of the 25 ALS cases (4%), but not in the 19 controls. No alpha-synuclein-immunoreactive structures were found in Schwann cells or the neuronal nucleus. Mean disease duration of MSA cases with alpha-synuclein-immunoreactive structures was significantly longer than that of MSA cases without alpha-synuclein-immunoreactive structures. alpha-Synuclein-immunoreactive structures in 4 cases proved to be Lewy bodies (LB) based on hematoxylin-eosin staining. A few LB were also found in the brains of 3 of these 4 cases. In the other 7 MSA cases, diffuse or focal neuronal cytoplasmic aggregates and swollen neurites were detected with alpha-synuclein immunostaining, but not with hematoxylin-eosin staining. However, a few LB-like structures with ring-like staining were observed in those aggregates, which suggested those aggregates had progressed to form LB. Immunoelectron microscopically, those aggregates were composed of filaments and granular materials which closely resembled the ultrastructural features of LB. We inferred that alpha-synuclein aggregates found in the SG in our study evidenced LB-related pathologies. MSA, a type of synucleinopathy, is characterized by glial cytoplasmic inclusions in oligodendrocytes, but also frequently develops LB pathology in the late stage, especially in the SG.

Authors+Show Affiliations

Department of Neurology, Nagoya University Graduate School of Medicine, Showa-ku, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15895299

Citation

Sone, Mie, et al. "Alpha-Synuclein-immunoreactive Structure Formation Is Enhanced in Sympathetic Ganglia of Patients With Multiple System Atrophy." Acta Neuropathologica, vol. 110, no. 1, 2005, pp. 19-26.
Sone M, Yoshida M, Hashizume Y, et al. Alpha-Synuclein-immunoreactive structure formation is enhanced in sympathetic ganglia of patients with multiple system atrophy. Acta Neuropathol. 2005;110(1):19-26.
Sone, M., Yoshida, M., Hashizume, Y., Hishikawa, N., & Sobue, G. (2005). Alpha-Synuclein-immunoreactive structure formation is enhanced in sympathetic ganglia of patients with multiple system atrophy. Acta Neuropathologica, 110(1), 19-26.
Sone M, et al. Alpha-Synuclein-immunoreactive Structure Formation Is Enhanced in Sympathetic Ganglia of Patients With Multiple System Atrophy. Acta Neuropathol. 2005;110(1):19-26. PubMed PMID: 15895299.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - alpha-Synuclein-immunoreactive structure formation is enhanced in sympathetic ganglia of patients with multiple system atrophy. AU - Sone,Mie, AU - Yoshida,Mari, AU - Hashizume,Yoshio, AU - Hishikawa,Nozomi, AU - Sobue,Gen, Y1 - 2005/05/14/ PY - 2004/12/02/received PY - 2005/02/14/accepted PY - 2005/02/10/revised PY - 2005/5/17/pubmed PY - 2005/10/28/medline PY - 2005/5/17/entrez SP - 19 EP - 26 JF - Acta neuropathologica JO - Acta Neuropathol VL - 110 IS - 1 N2 - We immunohistochemically examined the sympathetic ganglia (SG) and brains of 26 patients with multiple system atrophy (MSA), 19 age-matched controls, and 25 patients with amyotrophic lateral sclerosis (ALS). alpha-Synuclein-immunoreactive structures were found in the neuronal cytoplasm and processes of the SG in 11 of the 26 MSA cases (42.3%) and 1 of the 25 ALS cases (4%), but not in the 19 controls. No alpha-synuclein-immunoreactive structures were found in Schwann cells or the neuronal nucleus. Mean disease duration of MSA cases with alpha-synuclein-immunoreactive structures was significantly longer than that of MSA cases without alpha-synuclein-immunoreactive structures. alpha-Synuclein-immunoreactive structures in 4 cases proved to be Lewy bodies (LB) based on hematoxylin-eosin staining. A few LB were also found in the brains of 3 of these 4 cases. In the other 7 MSA cases, diffuse or focal neuronal cytoplasmic aggregates and swollen neurites were detected with alpha-synuclein immunostaining, but not with hematoxylin-eosin staining. However, a few LB-like structures with ring-like staining were observed in those aggregates, which suggested those aggregates had progressed to form LB. Immunoelectron microscopically, those aggregates were composed of filaments and granular materials which closely resembled the ultrastructural features of LB. We inferred that alpha-synuclein aggregates found in the SG in our study evidenced LB-related pathologies. MSA, a type of synucleinopathy, is characterized by glial cytoplasmic inclusions in oligodendrocytes, but also frequently develops LB pathology in the late stage, especially in the SG. SN - 0001-6322 UR - https://www.unboundmedicine.com/medline/citation/15895299/alpha_Synuclein_immunoreactive_structure_formation_is_enhanced_in_sympathetic_ganglia_of_patients_with_multiple_system_atrophy_ L2 - https://dx.doi.org/10.1007/s00401-005-1013-9 DB - PRIME DP - Unbound Medicine ER -