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Cumulative effects of calcium supplementation and physical activity on bone accretion in premenarchal children: a double-blind randomised placebo-controlled trial.
Int J Sports Med 2005; 26(5):332-8IJ

Abstract

High calcium intake combined with physical activity during childhood have been shown to improve bone mass accrual and bone mineral density. Our aim was to study the combined effect of calcium and exercise on bone gain in children. Two milk-powder products containing either 800 mg of calcium phosphate (calcium) or not (placebo) were randomly allocated to 113 healthy premenarchal girls on a daily basis for 1 year. The group was composed of 63 exercise (7.2 +/- 4 hours of exercise/week) and 50 sedentary (1.2 +/- 0.8 hours of exercise/week) children. The final experiment had 4 groups: exercise/calcium (n = 12), exercise/placebo (n = 42), sedentary/calcium (n = 10), and sedentary/placebo (n = 21). Bone mineral density (BMD) at 6 skeletal sites and body composition were determined by DXA. Bone age was calculated and the daily spontaneous calcium intake was assessed by a frequency questionnaire. All the tests were performed at baseline and 1 year by the same observer. BMD gains were significantly greater in the exercise/calcium group than in other groups at the total body (increase of 6.3 %, p < 0.05), lumbar spine (11 %, p < 0.05), femoral neck (8.2 %, p < 0.02), and Ward's triangle (9.3 %, p < 0.01). There was no difference between the other groups. These data suggest that calcium supplementation increases the effect of physical exercise on bone mineral acquisition in the period preceding puberty, and that calcium supplementation without physical activity does not improve the BMD acquisition during this period. Physical exercise that stimulates bone accretion needs a high calcium intake to be completely effective.

Authors+Show Affiliations

Laboratory of Exercise Physiology, Orléans University, France. daniel.courteix@univ-orleans.fr

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

15895314

Citation

Courteix, D, et al. "Cumulative Effects of Calcium Supplementation and Physical Activity On Bone Accretion in Premenarchal Children: a Double-blind Randomised Placebo-controlled Trial." International Journal of Sports Medicine, vol. 26, no. 5, 2005, pp. 332-8.
Courteix D, Jaffré C, Lespessailles E, et al. Cumulative effects of calcium supplementation and physical activity on bone accretion in premenarchal children: a double-blind randomised placebo-controlled trial. Int J Sports Med. 2005;26(5):332-8.
Courteix, D., Jaffré, C., Lespessailles, E., & Benhamou, L. (2005). Cumulative effects of calcium supplementation and physical activity on bone accretion in premenarchal children: a double-blind randomised placebo-controlled trial. International Journal of Sports Medicine, 26(5), pp. 332-8.
Courteix D, et al. Cumulative Effects of Calcium Supplementation and Physical Activity On Bone Accretion in Premenarchal Children: a Double-blind Randomised Placebo-controlled Trial. Int J Sports Med. 2005;26(5):332-8. PubMed PMID: 15895314.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cumulative effects of calcium supplementation and physical activity on bone accretion in premenarchal children: a double-blind randomised placebo-controlled trial. AU - Courteix,D, AU - Jaffré,C, AU - Lespessailles,E, AU - Benhamou,L, PY - 2005/5/17/pubmed PY - 2005/10/6/medline PY - 2005/5/17/entrez SP - 332 EP - 8 JF - International journal of sports medicine JO - Int J Sports Med VL - 26 IS - 5 N2 - High calcium intake combined with physical activity during childhood have been shown to improve bone mass accrual and bone mineral density. Our aim was to study the combined effect of calcium and exercise on bone gain in children. Two milk-powder products containing either 800 mg of calcium phosphate (calcium) or not (placebo) were randomly allocated to 113 healthy premenarchal girls on a daily basis for 1 year. The group was composed of 63 exercise (7.2 +/- 4 hours of exercise/week) and 50 sedentary (1.2 +/- 0.8 hours of exercise/week) children. The final experiment had 4 groups: exercise/calcium (n = 12), exercise/placebo (n = 42), sedentary/calcium (n = 10), and sedentary/placebo (n = 21). Bone mineral density (BMD) at 6 skeletal sites and body composition were determined by DXA. Bone age was calculated and the daily spontaneous calcium intake was assessed by a frequency questionnaire. All the tests were performed at baseline and 1 year by the same observer. BMD gains were significantly greater in the exercise/calcium group than in other groups at the total body (increase of 6.3 %, p < 0.05), lumbar spine (11 %, p < 0.05), femoral neck (8.2 %, p < 0.02), and Ward's triangle (9.3 %, p < 0.01). There was no difference between the other groups. These data suggest that calcium supplementation increases the effect of physical exercise on bone mineral acquisition in the period preceding puberty, and that calcium supplementation without physical activity does not improve the BMD acquisition during this period. Physical exercise that stimulates bone accretion needs a high calcium intake to be completely effective. SN - 0172-4622 UR - https://www.unboundmedicine.com/medline/citation/15895314/Cumulative_effects_of_calcium_supplementation_and_physical_activity_on_bone_accretion_in_premenarchal_children:_a_double_blind_randomised_placebo_controlled_trial_ L2 - http://www.thieme-connect.com/DOI/DOI?10.1055/s-2004-821040 DB - PRIME DP - Unbound Medicine ER -