Tags

Type your tag names separated by a space and hit enter

Evidence for the involvement of the opioid system in the agmatine antidepressant-like effect in the forced swimming test.
Neurosci Lett. 2005 Jun 24; 381(3):279-83.NL

Abstract

This study investigated the involvement of the opioid system in the antidepressant-like effect of agmatine in the mouse forced swimming test (FST). The antidepressant-like effects of agmatine (10 mg/kg, i.p.), as well as those of fluoxetine (32 mg/kg, i.p, a selective serotonin reuptake inhibitor, SSRI) or morphine (5 mg/kg, s.c., a nonselective opioid receptor agonist) in the FST was completely blocked by pretreatment of mice with naloxone (1 mg/kg, i.p., a nonselective opioid receptor antagonist). Pretreatment of mice with naltrindole (3 mg/kg, i.p., a selective delta-opioid receptor antagonist), clocinnamox (1 mg/kg, i.p., an irreversible mu-opioid receptor antagonist), but not with 2-(3,4-dichlorophenyl)-N-methyl-N-[(1S)-1-(3-isothiocyanatophenyl)-2-(1-pyrrolidinyl)ethyl]acetamide (DIPPA; 1 mg/kg, i.p., a selective kappa-opioid receptor antagonist) completely blocked the anti-immobility effect of agmatine (10 mg/kg, i.p.) in the FST. These results firstly demonstrate that the antidepressant-like effects of agmatine in the FST seem to be mediated, at least in part, by an interaction with the opioid system, that involves an activation of delta- and mu-opioid receptors.

Authors+Show Affiliations

Departamento de Bioquímica, Centro de Ciências Biológicas, Universidade Federal de Santa Catarina, Campus Universitário, Trindade, Florianópolis, SC 88040-900, Brazil.No affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15896484

Citation

Zomkowski, Andrea D E., et al. "Evidence for the Involvement of the Opioid System in the Agmatine Antidepressant-like Effect in the Forced Swimming Test." Neuroscience Letters, vol. 381, no. 3, 2005, pp. 279-83.
Zomkowski AD, Santos AR, Rodrigues AL. Evidence for the involvement of the opioid system in the agmatine antidepressant-like effect in the forced swimming test. Neurosci Lett. 2005;381(3):279-83.
Zomkowski, A. D., Santos, A. R., & Rodrigues, A. L. (2005). Evidence for the involvement of the opioid system in the agmatine antidepressant-like effect in the forced swimming test. Neuroscience Letters, 381(3), 279-83.
Zomkowski AD, Santos AR, Rodrigues AL. Evidence for the Involvement of the Opioid System in the Agmatine Antidepressant-like Effect in the Forced Swimming Test. Neurosci Lett. 2005 Jun 24;381(3):279-83. PubMed PMID: 15896484.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Evidence for the involvement of the opioid system in the agmatine antidepressant-like effect in the forced swimming test. AU - Zomkowski,Andrea D E, AU - Santos,Adair R S, AU - Rodrigues,Ana L S, Y1 - 2005/03/03/ PY - 2005/01/14/received PY - 2005/02/04/revised PY - 2005/02/09/accepted PY - 2005/5/18/pubmed PY - 2005/7/27/medline PY - 2005/5/18/entrez SP - 279 EP - 83 JF - Neuroscience letters JO - Neurosci Lett VL - 381 IS - 3 N2 - This study investigated the involvement of the opioid system in the antidepressant-like effect of agmatine in the mouse forced swimming test (FST). The antidepressant-like effects of agmatine (10 mg/kg, i.p.), as well as those of fluoxetine (32 mg/kg, i.p, a selective serotonin reuptake inhibitor, SSRI) or morphine (5 mg/kg, s.c., a nonselective opioid receptor agonist) in the FST was completely blocked by pretreatment of mice with naloxone (1 mg/kg, i.p., a nonselective opioid receptor antagonist). Pretreatment of mice with naltrindole (3 mg/kg, i.p., a selective delta-opioid receptor antagonist), clocinnamox (1 mg/kg, i.p., an irreversible mu-opioid receptor antagonist), but not with 2-(3,4-dichlorophenyl)-N-methyl-N-[(1S)-1-(3-isothiocyanatophenyl)-2-(1-pyrrolidinyl)ethyl]acetamide (DIPPA; 1 mg/kg, i.p., a selective kappa-opioid receptor antagonist) completely blocked the anti-immobility effect of agmatine (10 mg/kg, i.p.) in the FST. These results firstly demonstrate that the antidepressant-like effects of agmatine in the FST seem to be mediated, at least in part, by an interaction with the opioid system, that involves an activation of delta- and mu-opioid receptors. SN - 0304-3940 UR - https://www.unboundmedicine.com/medline/citation/15896484/Evidence_for_the_involvement_of_the_opioid_system_in_the_agmatine_antidepressant_like_effect_in_the_forced_swimming_test_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0304-3940(05)00202-8 DB - PRIME DP - Unbound Medicine ER -