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Cortical generators of slow evoked responses elicited by spatial and nonspatial auditory working memory tasks.
Clin Neurophysiol. 2005 Jul; 116(7):1644-54.CN

Abstract

OBJECTIVE

Slow evoked responses have been extensively studied using electrophysiological and neuroimaging methods, but there is no consensus regarding their generators. We investigated the generators of the P3 and positive slow wave (PSW) in the evoked responses to probes recorded during auditory working memory tasks to find out whether there is dissociation between functional networks involved in the generation of the P3 and PSW and between spatial and nonspatial auditory processing within this time window.

METHODS

Whole-head magneto-(MEG) and electroencephalography (EEG); analysis of MEG data using minimum-norm current estimates.

RESULTS

The associative temporal, occipito-temporal and parietal areas contributed to the generation of the slow evoked responses. The temporal source increased while the occipito-temporal source diminished activity during transition from the P3 to PSW. The occipito-temporal generator of the P3 was activated more during the spatial than nonspatial task, and the left temporal generator of the PSW tended to be more strongly activated during the nonspatial task.

CONCLUSIONS

These findings indicate that partially distinct functional networks generate the P3 and PSW and provide evidence for segregation of spatial and nonspatial auditory information processing in associative areas beyond the supratemporal auditory cortex.

SIGNIFICANCE

The present results support the dual-stream model for auditory information processing.

Authors+Show Affiliations

Neuroscience Unit, Institute of Biomedicine/Physiology, University of Helsinki, P.O. Box 63 (Haartmaninkatu 8), 00014 Helsinki, Finland.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15897006

Citation

Anurova, Irina, et al. "Cortical Generators of Slow Evoked Responses Elicited By Spatial and Nonspatial Auditory Working Memory Tasks." Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology, vol. 116, no. 7, 2005, pp. 1644-54.
Anurova I, Artchakov D, Korvenoja A, et al. Cortical generators of slow evoked responses elicited by spatial and nonspatial auditory working memory tasks. Clin Neurophysiol. 2005;116(7):1644-54.
Anurova, I., Artchakov, D., Korvenoja, A., Ilmoniemi, R. J., Aronen, H. J., & Carlson, S. (2005). Cortical generators of slow evoked responses elicited by spatial and nonspatial auditory working memory tasks. Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology, 116(7), 1644-54.
Anurova I, et al. Cortical Generators of Slow Evoked Responses Elicited By Spatial and Nonspatial Auditory Working Memory Tasks. Clin Neurophysiol. 2005;116(7):1644-54. PubMed PMID: 15897006.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cortical generators of slow evoked responses elicited by spatial and nonspatial auditory working memory tasks. AU - Anurova,Irina, AU - Artchakov,Denis, AU - Korvenoja,Antti, AU - Ilmoniemi,Risto J, AU - Aronen,Hannu J, AU - Carlson,Synnöve, PY - 2004/09/20/received PY - 2005/01/21/revised PY - 2005/02/20/accepted PY - 2005/5/18/pubmed PY - 2005/8/12/medline PY - 2005/5/18/entrez SP - 1644 EP - 54 JF - Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology JO - Clin Neurophysiol VL - 116 IS - 7 N2 - OBJECTIVE: Slow evoked responses have been extensively studied using electrophysiological and neuroimaging methods, but there is no consensus regarding their generators. We investigated the generators of the P3 and positive slow wave (PSW) in the evoked responses to probes recorded during auditory working memory tasks to find out whether there is dissociation between functional networks involved in the generation of the P3 and PSW and between spatial and nonspatial auditory processing within this time window. METHODS: Whole-head magneto-(MEG) and electroencephalography (EEG); analysis of MEG data using minimum-norm current estimates. RESULTS: The associative temporal, occipito-temporal and parietal areas contributed to the generation of the slow evoked responses. The temporal source increased while the occipito-temporal source diminished activity during transition from the P3 to PSW. The occipito-temporal generator of the P3 was activated more during the spatial than nonspatial task, and the left temporal generator of the PSW tended to be more strongly activated during the nonspatial task. CONCLUSIONS: These findings indicate that partially distinct functional networks generate the P3 and PSW and provide evidence for segregation of spatial and nonspatial auditory information processing in associative areas beyond the supratemporal auditory cortex. SIGNIFICANCE: The present results support the dual-stream model for auditory information processing. SN - 1388-2457 UR - https://www.unboundmedicine.com/medline/citation/15897006/Cortical_generators_of_slow_evoked_responses_elicited_by_spatial_and_nonspatial_auditory_working_memory_tasks_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1388-2457(05)00107-0 DB - PRIME DP - Unbound Medicine ER -