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Therapeutic options for the treatment of tinea capitis: griseofulvin versus fluconazole.
J Dermatolog Treat. 2005 Feb; 16(1):43-6.JD

Abstract

BACKGROUND

Tinea capitis is a relatively common fungal infection of childhood. Griseofulvin has been the mainstay of treatment for many years. However, newer oral antifungal agents are being used more frequently.

OBJECTIVE

Our purpose was to evaluate the therapeutic efficacy of fluconazole in comparison with griseofulvin in the treatment of tinea capitis.

METHODS

We performed a single-blind, randomized, prospective evaluation of 40 patients with a clinical and mycologic diagnosis of tinea capitis. One group received fluconazole for 4 weeks. The other group received griseofulvin for 6 weeks. Five clinical parameters were evaluated. Mycologic examinations were performed at baseline and at the end of 8 weeks.

RESULTS

Patients ranged in age from 1 to 16 years; 80% were boys and 20% were girls. Mycologic examinations disclosed Trichophyton verrucosum in 40% of patients, T. violaceum in 40% and Microsporum canis in 20%. At week 8, the griseofulvin-treated group showed a cure rate of 76%, and the fluconazole-treated group 78%. The cure rates were not statistically significant.

CONCLUSION

Fluconazole constitutes an alternative but, because of greater availability and lower cost, griseofulvin remains the treatment of choice for tinea capitis.

Authors+Show Affiliations

Dermatology, Shiraz University of Medical Sciences, Shiraz, Iran.No affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

15897167

Citation

Dastghaib, L, et al. "Therapeutic Options for the Treatment of Tinea Capitis: Griseofulvin Versus Fluconazole." The Journal of Dermatological Treatment, vol. 16, no. 1, 2005, pp. 43-6.
Dastghaib L, Azizzadeh M, Jafari P. Therapeutic options for the treatment of tinea capitis: griseofulvin versus fluconazole. J Dermatolog Treat. 2005;16(1):43-6.
Dastghaib, L., Azizzadeh, M., & Jafari, P. (2005). Therapeutic options for the treatment of tinea capitis: griseofulvin versus fluconazole. The Journal of Dermatological Treatment, 16(1), 43-6.
Dastghaib L, Azizzadeh M, Jafari P. Therapeutic Options for the Treatment of Tinea Capitis: Griseofulvin Versus Fluconazole. J Dermatolog Treat. 2005;16(1):43-6. PubMed PMID: 15897167.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Therapeutic options for the treatment of tinea capitis: griseofulvin versus fluconazole. AU - Dastghaib,L, AU - Azizzadeh,M, AU - Jafari,P, PY - 2005/5/18/pubmed PY - 2005/6/10/medline PY - 2005/5/18/entrez SP - 43 EP - 6 JF - The Journal of dermatological treatment JO - J Dermatolog Treat VL - 16 IS - 1 N2 - BACKGROUND: Tinea capitis is a relatively common fungal infection of childhood. Griseofulvin has been the mainstay of treatment for many years. However, newer oral antifungal agents are being used more frequently. OBJECTIVE: Our purpose was to evaluate the therapeutic efficacy of fluconazole in comparison with griseofulvin in the treatment of tinea capitis. METHODS: We performed a single-blind, randomized, prospective evaluation of 40 patients with a clinical and mycologic diagnosis of tinea capitis. One group received fluconazole for 4 weeks. The other group received griseofulvin for 6 weeks. Five clinical parameters were evaluated. Mycologic examinations were performed at baseline and at the end of 8 weeks. RESULTS: Patients ranged in age from 1 to 16 years; 80% were boys and 20% were girls. Mycologic examinations disclosed Trichophyton verrucosum in 40% of patients, T. violaceum in 40% and Microsporum canis in 20%. At week 8, the griseofulvin-treated group showed a cure rate of 76%, and the fluconazole-treated group 78%. The cure rates were not statistically significant. CONCLUSION: Fluconazole constitutes an alternative but, because of greater availability and lower cost, griseofulvin remains the treatment of choice for tinea capitis. SN - 0954-6634 UR - https://www.unboundmedicine.com/medline/citation/15897167/Therapeutic_options_for_the_treatment_of_tinea_capitis:_griseofulvin_versus_fluconazole_ L2 - https://www.tandfonline.com/doi/full/10.1080/09546630510025932 DB - PRIME DP - Unbound Medicine ER -